The effect of Amberlite-IR 120 H + resin to remove some organic compounds (N-alkyl pyridinium salts) from aqueous solutions at certain conditions was investigated. The effect of resin dosage, contact time, adsorbate concentration, ionic strength and solution temperature on the adsorption efficiency was examined. The experimental data collected generally proved that the adsorption efficiency decreased as the alkyl chain increased. The thermodynamic equilibrium parameters of the adsorption processes were evaluated and showed that the adsorption process is spontaneous, disordered and exothermic. Langmuir, Freundlich, Temkin and Dubinin-Radushkevich (D.R) isotherm models were applied based on the batch method. Freundlich, Temkin and D. R gave bilinear segments model based on the adsorbate initial concentrations except that for compound III where it gave straight of one segment for Temkin adsorption isotherm. Overall, Amberlite-IR 120 H + resin is effective in removing some N-alkyl pyridinium salts from an aqueous solution.