Adsorptive stripping voltammetry determination of methyldopa on the surface of a carboxylated multiwall carbon nanotubes modified glassy carbon electrode in biological and pharmaceutical samples

Rezaei, Behzad; Askarpour, Neda; Ensafi, Ali A.

doi:10.1016/j.colsurfb.2013.04.004

Cited by 28 publications

(13 citation statements)

References 28 publications

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“…The regression equations are Ip (µA) = 0.0289  (mV s -1 ) + 2.184 (R= 0.996) for CPE and Ip (µA) = 0.1019  (mV s -1 ) + 8.956 (R=0.995) for In2O3 NPs/CPE. Such behavior suggests that the oxidation of FMT at CPE and In2O3 NPs/CPE is a typical adsorption-controlled electrode process [39,40].…”

Section: Electrochemical Behavior Of Fmt On Cpe and Modified In2o3 Npmentioning

confidence: 97%

Indium oxide nanoparticles modified carbon paste electrode for sensitive voltammetric determination of aromatase inhibitor formestane

Ibrahim¹,

Temerk²,

Ibrahim³

et al. 2015

Sensors and Actuators B: Chemical

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Section: Electrochemical Behavior Of Fmt On Cpe and Modified In2o3 Npmentioning

confidence: 97%

Indium oxide nanoparticles modified carbon paste electrode for sensitive voltammetric determination of aromatase inhibitor formestane

Ibrahim¹,

Temerk²,

Ibrahim³

et al. 2015

Sensors and Actuators B: Chemical

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“…On the other hand, analytical methods based on voltammetric stripping techniques have been recently benefited from the unique properties of CNT modified electrodes 29. A stronger adsorption of many organic compounds on CNTs in comparison with conventional electrode materials has been recently used for the determination of quercetin 30, 31 paracetamol 32, antiretroviral drug Abacavir 33, 4‐hexylresorcinol 34 or methyldopa 35. Thus, in this paper it is reported the application of COOH functionalized MWCNT modified SPCEs for the detection of uric acid by adsorptive voltammetry.…”

Section: Introductionmentioning

confidence: 99%

Uric Acid Determination by Adsorptive Stripping Voltammetry on Multiwall Carbon Nanotubes Based Screen‐Printed Electrodes

et al. 2015

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A sensitive electroanalytical methodology for the determination of uric acid in real samples using adsorptive voltammetry at a multiwalled carbon nanotubes (MWCNT) modified screen printed electrode (SPCE) is presented. Adsorption of uric acid takes place at open circuit potential at an optimized pH 5.0. Studies about the effect of accumulation time and scan rate on the analytical signal were developed and confirm the adsorption nature of the electrodic process. Quantitative analysis of uric acid by using its oxidation process at +0.18 V (vs. an Ag pseudoreference electrode) was carried out with an accumulation time of 5 min. Thus, a linear voltammetric based reproducible determination of uric acid (RSD 5 %) in the range 1–100 µM was obtained. The method was then successfully used for the determination of uric acid in real clinical samples of urine without detection of interferences. The proposed methodology only requires a dilution of the real sample and present advantages as low cost and easy handling for non specialized technicians.

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“…Of the techniques used in several procedures most are based on kinetic measurements (James;Hoo;William, 2006), highperformance liquid chromatography (Bahrami, Kiani, Mirzaeei, 2006;Muzzi et al, 2008;Li et al, 2010), voltammetry (Rezaei, Askarpour, Ensafi, 2013), spectrophotometry (Gadkariem et al, 2009;Brasil, 2010;Matos,Silva;Ribeiro, 2012; and diffuse reflectance spectroscopy (Ribeiro, Pezza, Pezza, 2006).…”

Section: Introductionmentioning

confidence: 99%

Development and application of a portable instrument for drugs analysis in pharmaceutical preparations

Ribeiro

Pezza

et al. 2015

Braz. J. Pharm. Sci.

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This article describes the application and performance of an inexpensive, simple and portable device for colorimetric quantitative determination of drugs in pharmaceutical preparations. The sensor is a light detector resistor (LDR) incorporated into a black PTFE cell and coupled to a low-cost multimeter (Ohmmeter). Quantitative studies were performed with captopril/p-chloranil/H 2 O 2 and methyldopa/ ammonium molybdate systems. Calibration curves were obtained by plotting the electrical resistance of the LDR against the concentration of the colored species in the ranges 1.84 × 10 -4 to 1.29 × 10 -3 mol L -1 and 5.04 × 10 -4 to 2.52 × 10 -3 mol L -1 for captopril/p-chloranil/H 2 O 2 and methyldopa/ammonium molybdate systems, respectively, exhibiting good coefficients of determination. Statistical analysis of the results obtained showed no significant difference between the proposed methodologies and the official reported methods, as evidenced by the t-test and variance ratio at a 95% confidence level. The results of this study demonstrate the applicability of the instrument for simple, accurate, precise, fast, in situ and low-cost colorimetric analysis of drugs in pharmaceutical products. Uniterms:Optical sensor/application/colorimetric analysis. Instrumentation/drugs dosage. Drugs/ quantitative analysis. Drugs/dosage. Pharmaceutical formulations/quality control.Este artigo descreve o desenvolvimento e a aplicação de um dispositivo portátil, simples e barato para a determinação colorimétrica quantitativa de fármacos em formulações farmacêuticas. O sensor é um resistor detector de luz (RDL) colocado numa célula de PTFE e acoplado a um multímetro de baixo custo. Os estudos quantitativos foram realizados utilizando captopril/p-cloranil/H 2 O 2 e metildopa/molibdato de amônio como sistemas reacionais. As curvas de calibração foram obtidas através da representação gráfica da resistência elétrica do RDL contra a concentração dos complexos coloridos formados nas faixas de 1,84 × 10 -4 e 1,29 × 10 -3 mol L -1 e 5,04 × 10 -4 e 2,52 × 10 -3 mol L -1 para captopril/p-cloranil/H 2 O 2 e de metildopa/molibdato de amônio, respectivamente, com bons coeficientes de determinação. As análises estatísticas dos resultados obtidos mostraram que não houve diferença significativa entre os métodos propostos e os métodos oficiais como evidente a partir dos testes "t-Student" e F-Fisher, com nível de confiança de 95%. Os resultados deste estudo demonstram que o instrumento proposto neste trabalho é simples, de fácil operação, baixo custo e apresentou boa exatidão e boa precisão para o doseamento de fármacos em medicamentos.Unitermos: Sensor óptico/aplicação/análise colorimétrica. Instrumentação/doseamento de fármacos. Fármacos/análise quantitativa. Fármacos/doseamento. Formulações farmacêuticas/controle de qualidade.

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Adsorptive stripping voltammetry determination of methyldopa on the surface of a carboxylated multiwall carbon nanotubes modified glassy carbon electrode in biological and pharmaceutical samples

Cited by 28 publications

References 28 publications

Indium oxide nanoparticles modified carbon paste electrode for sensitive voltammetric determination of aromatase inhibitor formestane

Indium oxide nanoparticles modified carbon paste electrode for sensitive voltammetric determination of aromatase inhibitor formestane

Uric Acid Determination by Adsorptive Stripping Voltammetry on Multiwall Carbon Nanotubes Based Screen‐Printed Electrodes

Development and application of a portable instrument for drugs analysis in pharmaceutical preparations

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