Adsorptive voltammetric procedure for the determination of platinum baseline levels in human body fluids

Messerschmidt, J.; Alt, F.; Tölg, G.; Angerer, J.; Schaller, K. H.

doi:10.1007/bf00322878

Cited by 148 publications

(44 citation statements)

References 10 publications

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“…This highly sensitive method, described by Weber et al (2004), allowed the determination of platinum with a lower limit of quantification of 0.4 pg ml À1 (Messerschmidt et al, 1992;Gelevert et al, 2001). In brief, the residue of the dried eluate was decomposed to mineralisation using a high-pressure asher (HPA, Kürner, Rosenheim, Germany).…”

Section: Determination Of Platinum-dna Adducts In Wbcmentioning

confidence: 99%

“…In brief, the residue of the dried eluate was decomposed to mineralisation using a high-pressure asher (HPA, Kürner, Rosenheim, Germany). A detailed description of the mineralisation process is given by Messerschmidt et al (1992). Platinum was then quantified by adsorptive stripping voltammetry using a Metrohm Polarecord 626 (Metrohm, Herisau, Switzerland).…”

Section: Determination Of Platinum-dna Adducts In Wbcmentioning

confidence: 99%

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Oxaliplatin-DNA adduct formation in white blood cells of cancer patients

et al. 2008

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In this study, we investigated the kinetics of oxaliplatin-DNA adduct formation in white blood cells of cancer patients in relation to efficacy as well as oxaliplatin-associated neurotoxicity. Thirty-seven patients with various solid tumours received 130 mg m À2 oxaliplatin as a 2-h infusion. Oxaliplatin-DNA adduct levels were measured in the first cycle using adsorptive stripping voltammetry. Platinum concentrations were measured in ultrafiltrate and plasma using a validated flameless atomic absorption spectrometry method. DNA adduct levels showed a characteristic time course, but were not correlated to platinum pharmacokinetics and varied considerably among individuals. In patients showing tumour response, adduct levels after 24 and 48 h were significantly higher than in nonresponders. Oxaliplatin-induced neurotoxicity was more pronounced but was not significantly different in patients with high adduct levels. The potential of oxaliplatin-DNA adduct measurements as pharmacodynamic end point should be further investigated in future trials.

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Section: Determination Of Platinum-dna Adducts In Wbcmentioning

confidence: 99%

Section: Determination Of Platinum-dna Adducts In Wbcmentioning

confidence: 99%

Oxaliplatin-DNA adduct formation in white blood cells of cancer patients

et al. 2008

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“…Directly after collecting, the urine was aliquoted in 100ml -portions, acidified with acetic acid and stored at À 188C. Determination of platinum was carried out according to a method of Messerschmidt et al (1992 ) by means of adsorptive inverse voltammetry in the differential pulse mode ( DPP ) using the standard addition procedure. After complete removal of the biological matrix by UV digestion, platinum in oxidation state +II was converted to a formazone complex by addition of formaldehyde and hydrazine.…”

Section: Environmental Health Datamentioning

confidence: 99%

Influences on human internal exposure to environmental platinum

Herr

Jankofsky

Angerer

et al. 2003

J Expo Sci Environ Epidemiol

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Different influences on internal exposure to platinum are investigated and for the first time weighted in environmentally exposed subjects as far as individual internal platinum concentrations are concerned. Detailed medical and environmental histories as well as oral cavity status were assessed in 84 dermatological patients, and internal platinum exposure was determined by analyzing platinum in urine using adsorptive voltammetry ( AV ). Platinum concentrations ranged from < 0.9 ( detection limit ) to 65.5 ng Pt / l urine. Influence of different types and age of alloy restorations and therefore relevance of the exposure pathway due to solubilization of platinum in saliva could be demonstrated. No platinum -related health effects ( contact stomatitis, asthma or kidney conditions ) were observed. Analysis of covariance showed the number of noble dental alloy restorations ( P < 0.0001 ) and to a lesser extent age ( P= 0.0017 ) to independently influence internal platinum exposure. Even though spread of environmental platinum has increased, internal platinum exposure is low in subjects without assessable medical or dental devices ( usually < 4.5 ng / l urine ) and not related to adverse health effects. For the first time, detailed individual information on possible exposure pathways to platinum were considered in an analysis of relevant influential factors: Car traffic exposure and dermatological condition showed no association with internal platinum exposure. Uptake from platinum containing noble metal dental alloy restorations ( NMDAR ) is of greatest relevance, surmounting the influence of each year of lifetime on platinum body load by more than 10 -fold.

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“…Very important is the paper published by Messerschmidt et al [102]. The authors propose the voltammetric determination of Pt(II) baseline levels in human body fluids (urine, blood and blood plasma).…”

Section: Human Biological Samplesmentioning

confidence: 98%

“…Sures and Zimmermann [86, 96 -99], and Alt et al [100,101] proposed interesting procedures for the determination of Pt(II) and Rh(III) in biological matrices as mussels (Dreissena polymorpha) and fish organs (Barbus barbus and Anguilla anguilla), applying the method suggested by Messerschmidt et al [102].…”

Section: Fish and Musselmentioning

confidence: 99%

Voltammetric Analysis of Trace Levels of Platinum Group Metals – Principles and Applications

Locatelli

2007

Electroanalysis

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The compelling use of autocatalytic converters, containing platinum group metals (PGMs), has been the cause, in the environmental and biological matrices, of an increasing concentration of such metals. For this reason, in the last decade, the literature has reported several papers regarding analytical procedures for the determination of Pt(II), Pd(II) and Rh(III) in real samples, generally employing spectroscopic methods. The present review intends to highlight the contribution of the voltammetric techniques for the determination of these metals, including also those less investigated, i.e. Iridium, Osmium and Ruthenium.

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Adsorptive voltammetric procedure for the determination of platinum baseline levels in human body fluids

Cited by 148 publications

References 10 publications

Oxaliplatin-DNA adduct formation in white blood cells of cancer patients

Oxaliplatin-DNA adduct formation in white blood cells of cancer patients

Influences on human internal exposure to environmental platinum

Voltammetric Analysis of Trace Levels of Platinum Group Metals – Principles and Applications

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