Adult Acute Leukaemia

Atkinson, K; Wells, David G.; Clink, H.M.; Kay, H. E. M.; Powles, R; McElwain, T. J.

doi:10.1038/bjc.1974.191

Cited by 10 publications

(2 citation statements)

References 9 publications

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“…Furthermore, PAS positivity was seen in only 50%0 of the series of ALL patients recently reported by Atkinson et al (1974). The overlap between ALL and AML cells with respect to their ADA levels means that this enzymatic assay cannot be used diagnostically in isolation but, used in conjunction with the above techniques, the presence of a very high ADA or of an ADA level within the normal range may be of use diagnostically when evaluating undifferentiated acute leukaemias.…”

Section: Resultsmentioning

confidence: 99%

Adenosine deaminase activity in leukaemia

Smyth¹,

Harrap²

1975

Br J Cancer

101

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Summary.-Adenosine deaminase (EC 3.5.4.4., ADA) has been measured in the blast cells of 36 patients with acute lymphoblastic, acute myeloid, chronic myeloid and chronic myeloid blast crisis leukaemia. Particularly high levels were found in acute lymphoblastic and chronic myeloid blast crisis patients. The measurement of ADA may be useful diagnostically in the undifferentiated acute leukaemias and in detecting the early onset of blast crisis in chronic myeloid leukaemia. Possible reasons for the elevation of ADA in malignant cells are discussed.

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Section: Resultsmentioning

confidence: 99%

Adenosine deaminase activity in leukaemia

Smyth¹,

Harrap²

1975

Br J Cancer

101

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“…36 However, improvements in supportive care, more intensive chemotherapeutic regimens, and HSCT have led to improved survival in AML, also at a population level. 26 One subtype of AML, APL, can be treated with several specific agents including all trans retinoic acid 37 and arsenic trioxide, 38 treatments introduced in the late 1990s and early 21 st century.…”

Section: © F E R R a T A S T O R T I F O U N D A T I O Nmentioning

confidence: 99%

Recent trends in survival of adult patients with acute leukemia: overall improvements, but persistent and partly increasing disparity in survival of patients from minority groups

et al. 2012

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Relapse Following Marrow Transplantation for Acute Leukemia

et al. 1978

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One-hundred-thirty-six patients who underwent marrow transplantation for endstage acute leukemia were studied with respect t o factors that might predict failure t o eradicate or recurrence of leukemia following transplantation. One-hundred-five patients were recipients of allogeneic and 3 1 recipients of syngeneic marrow. Sixty-four patients had acute lymphoblastic leukemia (ALL) and 72 acute nonlymphoblastic leukemia (ANL). The frequency of persistence of leukemia and relapse was 35% for patients with ANL and 44% for those with ALL. sidered simultaneously through proportional hazards modeling showed only the WBC at admission for transplantation t o be significant (P = 0.02). The presence of an enlarged spleen, either at diagnosis or at transplantation, was associated with an increased probability of relapse (P < 0.006) among patients with ANL. In patients with ALL, active central nervous system (CNS) disease at the time of transplantation significantly increased the risk of relapse in the CNS (P < 0.01). Patients with a white blood cell (WBC) count greater than 20,000/mm3 at admission for transplantation had an increased rate of relapse (P < 0.003). Patients whose leukemic cells showed a karyotypic abnormality on cytogenetic analysis had an increased probability of relapse as compared t o those with karyotypically normal leukemic cells (P = 0.04). Following transplantation, the persistence of leukemic cells in the marrow one week after transplantation indicated an increased likelihood of failure to achieve remission and an increased likelihood of subsequent relapse in those who achieved a remission (P < 0.001).When all the patients are considered as one group pretransplant factors con-

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Adult Acute Leukaemia

Cited by 10 publications

References 9 publications

Adenosine deaminase activity in leukaemia

Adenosine deaminase activity in leukaemia

Recent trends in survival of adult patients with acute leukemia: overall improvements, but persistent and partly increasing disparity in survival of patients from minority groups

Relapse Following Marrow Transplantation for Acute Leukemia

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