Adult age-dependent differences in resting-state connectivity within and between visual-attention and sensorimotor networks

Roski, Christian; Caspers, Svenja; Langner, Robert; Laird, Angela R.; Fox, Peter T.; Zilles, Karl; Amunts, Katrin; Eickhoff, Simon B.

doi:10.3389/fnagi.2013.00067

Cited by 48 publications

(42 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We observed that age was associated with mixed higher and lower weight across the brain, though frontal connections were relatively unaltered. This possibly reflects brain-wide reorganization in age (Grady et al, 2006; Roski et al, 2013) and may explain the higher diversity seen in the DMN with age.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Weighted brain networks in disease: centrality and entropy in human immunodeficiency virus and aging

Thomas

Brier

Ortega

et al. 2015

Neurobiology of Aging

View full text Add to dashboard Cite

Graph theory models can produce simple, biologically informative metrics of the topology of resting-state functional connectivity (FC) networks. However, typical graph theory approaches model FC relationships between regions (nodes) as unweighted edges, complicating their interpretability in studies of disease or aging. We extended existing techniques and constructed fully-connected weighted graphs for groups of age-matched HIV positive (n=67) and HIV negative (n=77) individuals. We compared test-retest reliability of weighted vs. unweighted metrics in an independent study of healthy individuals (n=22) and found weighted measures to be more stable. We quantified two measures of node centrality (closeness centrality and eigenvector centrality) to capture the relative importance of individual nodes. We also quantified one measure of graph entropy (diversity) to measure the variability in connection strength (edge weights) at each node. HIV was primarily associated with differences in measures of centrality, and age was primarily associated with differences in diversity. HIV and age were associated with divergent measures when evaluated at the whole-graph level, within individual functional networks, and at the level of individual nodes. Graph models may allow us to distinguish previously indistinguishable effects related to HIV and age on FC.

show abstract

Section: Discussionmentioning

confidence: 99%

“…It has been observed that aging is associate with dedifferentiation in the brain network, causing brain regions to become less specialized (Li and Lindenberger, 1999; Roski et al, 2013). We observed that age was correlated with higher global graph entropy, particularly strong in the DMN.…”

Section: Discussionmentioning

confidence: 99%

Weighted brain networks in disease: centrality and entropy in human immunodeficiency virus and aging

Thomas

Brier

Ortega

et al. 2015

Neurobiology of Aging

View full text Add to dashboard Cite

show abstract

“…Previous imaging studies suggest that aging is related in a complicated way to cerebral functional connectivities, with different brain areas increasing and decreasing with age in connectivity to regions of interest (Bernard et al, 2013; Campbell et al, 2013; Hafkemeijer et al, 2013; Hoffstaedter et al, 2014; Liu et al, 2012; Roski et al, 2013; Taniwaki et al, 2007; Ystad et al, 2010; see also Ferreira and Busatto, 2013 for a review). Here, we observed that age is associated with increased BNM connectivity to subcortical structures including the midbrain and pallidum and decreased connectivity to somatomotor and visual cortices.…”

Section: Discussionmentioning

confidence: 99%

Resting state functional connectivity of the basal nucleus of Meynert in humans: In comparison to the ventral striatum and the effects of age

Ide

Zhang

et al. 2014

NeuroImage

View full text Add to dashboard Cite

The basal nucleus of Meynert (BNM) provides the primary cholinergic inputs to the cerebral cortex. Loss of neurons in the BNM is linked to cognitive deficits in Alzheimer’s disease and other degenerative conditions. Numerous animal studies described cholinergic and non-cholinergic neuronal responses in the BNM; however, work in humans has been hampered by the difficulty of defining the BNM anatomically. Here, on the basis of a previous study that delineated the BNM of post-mortem human brains in a standard stereotaxic space, we sought to examine functional connectivity of the BNM, as compared to the nucleus accumbens (or ventral striatum, VS), in a large resting state functional magnetic resonance imaging data set. The BNM and VS shared but also showed a distinct pattern of cortical and subcortical connectivity. Compared to the VS, the BNM showed stronger positive connectivity with the putamen, pallidum, thalamus, amygdala and midbrain, as well as the anterior cingulate cortex, supplementary motor area and pre-supplementary motor area, a network of brain regions that respond to salient stimuli and orchestrate motor behavior. In contrast, compared to the BNM, the VS showed stronger positive connectivity with the ventral caudate and medial orbitofrontal cortex, areas implicated in reward processing and motivated behavior. Furthermore, the BNM and VS each showed extensive negative connectivity with visual and lateral prefrontal cortices. Together, the distinct cerebral functional connectivities support the role of the BNM in arousal, saliency responses and cognitive motor control and the VS in reward related behavior. Considering the importance of BNM in age-related cognitive decline, we explored the effects of age on BNM and VS connectivities. BNM connectivity to the visual and somatomotor cortices decreases while connectivity to subcortical structures including the midbrain, thalamus, and pallidum increases with age. These findings of age-related changes of cerebral functional connectivity of the BNM may facilitate research of the neural bases of cognitive decline in health and illness.

show abstract

“…The observed age-dependent reductions in anti-correlation between these regions and several of our task-related network nodes might thus reflect difficulties in recruiting task-relevant regions selectively in advanced age, leading to “intrusions” or interference from task-irrelevant cognition (cf. Mason et al, 2007; Roski et al, 2013a; Weissman et al, 2006). Such potentially dysfunctional age-related changes in FC between functionally distinct brain networks (i.e., neural de-differentiation) have been recently reported for visual-attention and sensorimotor networks (Roski et al, 2013b) and might contribute to the behavioural deficits observed in Experiment 1 by undermining proper task-set implementation in the elderly.…”

Section: Methodsmentioning

confidence: 99%

Aging and response conflict solution: behavioural and functional connectivity changes

et al. 2014

Self Cite

View full text Add to dashboard Cite

Healthy aging has been found associated with less efficient response conflict solution, but the cognitive and neural mechanisms remain elusive. In a two-experiment study, we first examined the behavioural consequences of this putative age-related decline for conflicts induced by spatial stimulus–response incompatibility. We then used resting-state functional magnetic resonance imaging data from a large, independent sample of adults (n = 399; 18–85 years) to investigate age differences in functional connectivity between the nodes of a network previously found associated with incompatibility-induced response conflicts in the very same paradigm. As expected, overcoming interference from conflicting response tendencies took longer in older adults, even after accounting for potential mediator variables (general response speed and accuracy, motor speed, visuomotor coordination ability, and cognitive flexibility). Experiment 2 revealed selective age-related decreases in functional connectivity between bilateral anterior insula, pre-supplementary motor area, and right dorsolateral prefrontal cortex. Importantly, these age effects persisted after controlling for regional gray-matter atrophy assessed by voxel-based morphometry. Meta-analytic functional profiling using the BrainMap database showed these age-sensitive nodes to be more strongly linked to highly abstract cognition, as compared with the remaining network nodes, which in turn were more strongly linked to action-related processing. These findings indicate changes in interregional coupling with age among task-relevant network nodes that are not specifically associated with conflict resolution per se. Rather, our behavioural and neural data jointly suggest that healthy aging is associated with difficulties in properly activating non-dominant but relevant task schemata necessary to exert efficient cognitive control over action.

show abstract

Adult age-dependent differences in resting-state connectivity within and between visual-attention and sensorimotor networks

Cited by 48 publications

References 78 publications

Weighted brain networks in disease: centrality and entropy in human immunodeficiency virus and aging

Weighted brain networks in disease: centrality and entropy in human immunodeficiency virus and aging

Resting state functional connectivity of the basal nucleus of Meynert in humans: In comparison to the ventral striatum and the effects of age

Aging and response conflict solution: behavioural and functional connectivity changes

Contact Info

Product

Resources

About