Adult and pediatric anesthesia/sedation for gastrointestinal procedures outside of the operating room

Er, Michel Foehn

doi:10.1097/aco.0000000000000215

Cited by 10 publications

(5 citation statements)

References 71 publications

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“…From their reports, decreased entries to the top of the tank and locomotor activity were displayed by treated fishes, reflecting the sedative effects of this compound. These effects were also shown in humans, rodents, and zebrafish larvae [87][88][89][90]. However, further clinical and experimental studies to explore the central nervous system (CNS) action of this compound are necessary to elucidate these outcomes.…”

Section: Discussionmentioning

confidence: 99%

Acute and Chronic Effects of Fin Amputation on Behavior Performance of Adult Zebrafish in 3D Locomotion Test Assessed with Fractal Dimension and Entropy Analyses and Their Relationship to Fin Regeneration

Audira

Suryanto

Chen

et al. 2022

Biology

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The fin is known to play an important role in swimming for many adult fish, including zebrafish. Zebrafish fins consist of paired pectoral and pelvic with unpaired dorsal, anal, and caudal tail fins with specific functions in fish locomotion. However, there was no study comparing the behavior effects caused by the absence of each fin. We amputated each fin of zebrafish and evaluated their behavior performance in the 3D locomotion test using fractal dimension and entropy analyses. Afterward, the behavior recovery after the tail fin amputation was also evaluated, together with the fin regeneration process to study their relationship. Finally, we conducted a further study to confirm whether the observed behavior alterations were from pain elicited by fin amputation procedure or not by using lidocaine, a pain-relieving drug. Amputation in the caudal fin resulted in the most pronounced behavior alterations, especially in their movement complexity. Furthermore, we also found that their behavior was fully recovered before the caudal fin was fully regenerated, indicating that these behavioral changes were not majorly due to a mechanical change in tail length; instead, they may come from pain elicited from the fin amputation, since treatment with lidocaine could ameliorate the behavioral effects after the amputation procedure. However, lidocaine did not accelerate the behavior recovery process; instead, it caused the fishes to display some slight side effects. This study highlights the potential moderate severity of fin amputation in zebrafish and the importance of analgesia usage. However, side effects may occur and need to be considered since fin amputation is routinely conducted for various research, especially genomic screening.

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Section: Discussionmentioning

confidence: 99%

Acute and Chronic Effects of Fin Amputation on Behavior Performance of Adult Zebrafish in 3D Locomotion Test Assessed with Fractal Dimension and Entropy Analyses and Their Relationship to Fin Regeneration

Audira

Suryanto

Chen

et al. 2022

Biology

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“…El 80,4% fue ASA II y ASA III con una edad promedio de 56 años, y con una población mayor a 70 años del 26,8%. Hallazgos que pudieran ser similares a los reportados [6], [8], [9], [10]. En la revisión de Kim et al, se encontró que la edad mayor a 70 años era el 20% en AFQ frente al 12% en salas de cirugía y el 69% de los casos de AFQ estaban en las categorías III-V de ASA frente a 44% para casos de quirófano [8].…”

Section: Discussionunclassified

“…En una revisión detallada de los casos de reclamos, el 51% eran de gastroentero-logía, seguido de cardiología 29%, radiología intervencionista 17% [21]. En dos estudios se ha visto que los predictores de complicaciones incluyen aumento de comorbilidades, la edad mayor a 70 años, ASA mayor a III y la duración del procedimiento [9], [10], [22]. Gran parte de nuestra población tiene más de 70 años y tienen un mayor ASA y el 70% de la duración de los procedimientos eran menos de 30 minutos, eso podría explicar la baja tasa de complicaciones.…”

Section: Discussionunclassified

Satisfacción de pacientes en servicio de anestesia fuera de quirófano. Aplicación Escala ISAS

Martínez González,

Mayorga Anaya,

Meléndez

et al. 2023

Rev. chil. anest.

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Introducción: Con el advenimiento de nuevas técnicas quirúrgicas, los procedimientos fuera de salas de cirugía han venido en aumento significativo. La satisfacción de los pacientes tras un acto anestésico es una medida de calidad de la asistencia que contribuye a la evaluación del centro sanitario. Objetivos: Describir la satisfacción, así como las características clínicas y sociodemográficas de los pacientes que fueron llevados a anestesia fuera del quirófano (AFQ) por medio de la aplicación de la Escala Iowa Satisfaction with Anesthesia Scale (ISAS). Materiales y Métodos: Se realizó un estudio analítico tipo corte transversal, en procedimientos de AFQ, Se incluyeron 145 pacientes mayores de 18 años a quienes se les aplicó la escala ISAS. Se realizó la evaluación de la escala en términos de validez, fiabilidad, consistencia interna y aceptabilidad. Resultados y Conclusiones: Todos los 145 pacientes recibieron sedación, el 92% fueron de gastroenterología. Se encontró una fiabilidad buena por un alfa de Cronbach de 0,76. Se hizo una evaluación del coeficiente de correlación de Pearson entre el resultado promedio de cada pregunta de la escala con la respuesta a la pregunta N°2 con evidencia en las preguntas de carácter positivo una validez convergente buena. El 95,17% se clasifico como “totalmente satisfecho” con la anestesia recibida, el medicamento más usado por los anestesiólogos fue el propofol en 93%. Se puede decir que la escala ISAS en los pacientes AFQ se puede usar para medir satisfacción de la anestesia.

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“…However, the administration of anesthesia outside the operating room, as is joint in painless colonoscopy, introduces additional considerations, including the risks associated with analgesics, such as respiratory depression and hemodynamic instability [11][12][13][14][15][16]. These anesthesia-related risks necessitate careful selection of analgesic agents that provide effective pain relief while minimizing adverse effects, particularly in outpatient settings where rapid recovery and discharge are desired [17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Comparative Efficacy and Safety of Nalbuphine and Hydromorphone in Painless Colonoscopy Techniques: A Randomized Controlled Trial

Hou,

Zhang,

Chen

et al. 2024

Preprint

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Background: Colonoscopy is essential for diagnosing colon lesions but is often associated with discomfort. Painless colonoscopy techniques are being increasingly used to improve the patient experience." However, in the case of painless colonoscopy, anesthesia is performed outside the operating room, which requires more significant peri-examination of hemodynamic changes and adverse postoperative reactions. This requires a more careful selection of narcotic analgesics, and there needs to be optimal analgesic drug guidance in clinical practice. This study compared the efficacy and safety of nalbuphine and hydromorphone in improving patient comfort and maintaining hemodynamic stability during elective colonoscopy. Methods: This prospective, randomized, double-blinded controlled trial included 72 adult patients (aged 18-65) who underwent sedation colonoscopy. The 72 patients were randomly divided into two groups using a computer-generated random sequence. Body mass index 18.5-28.0 kg/m2; American Society of Anesthesiologists (ASA) grade I to II. Then, the nalbuphine group was given 0.13 mg/kg nalbuphine, the hydromorphone group was given 0.016 mg/kg hydromorphone, and during the operation, 10-20 mg/time propofol could be appropriately injected according to the patient's examination and cooperation. All patients were continuously monitored for oxygen saturation, heart rate, and noninvasive mean arterial blood pressure. The colonoscopy time and anesthesia time were recorded. Adverse reactions such as hypotension, decreased oxygen saturation, nausea, and vomiting were recorded. Anesthesiologist satisfaction, gastroenterologist (operator), and patient satisfaction were recorded. Results: Both nalbuphine and hydromorphone effectively maintained hemodynamic stability, with no significant differences in vital signs observed between the groups (P > 0.05). However, nalbuphine significantly reduced the incidence of postoperative nausea, vomiting, dizziness, and headache compared to hydromorphone (P < 0.05). The reduced side effects of nalbuphine were marked, suggesting a better postoperative comfort profile. Conclusions: While nalbuphine and hydromorphone effectively maintain intraoperative vital signs, nalbuphine offers superior postoperative comfort. This makes nalbuphine a preferable analgesic choice in outpatient colonoscopy settings. Further research is warranted to determine the optimal dosages for both drugs and to explore their mechanisms of action in procedural pain management. Register Number: ChiCTR2300077446

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Adult and pediatric anesthesia/sedation for gastrointestinal procedures outside of the operating room

Cited by 10 publications

References 71 publications

Acute and Chronic Effects of Fin Amputation on Behavior Performance of Adult Zebrafish in 3D Locomotion Test Assessed with Fractal Dimension and Entropy Analyses and Their Relationship to Fin Regeneration

Acute and Chronic Effects of Fin Amputation on Behavior Performance of Adult Zebrafish in 3D Locomotion Test Assessed with Fractal Dimension and Entropy Analyses and Their Relationship to Fin Regeneration

Satisfacción de pacientes en servicio de anestesia fuera de quirófano. Aplicación Escala ISAS

Comparative Efficacy and Safety of Nalbuphine and Hydromorphone in Painless Colonoscopy Techniques: A Randomized Controlled Trial

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