Adult asthma is associated with an increased risk of herpes zoster: A population-based cohort study

Peng, Yen‐Chun; Fang, Hsin Yu; Wu, Biing Ru; Kao, Chia Hung; Chen, Hsuan Ju; Hsia, Te Chun; Liao, Wei

doi:10.1080/02770903.2016.1211142

Cited by 27 publications

(25 citation statements)

References 29 publications

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“…Moreover, although the patients with HZ definition was subjects without concurrent received antiviral medication, several related publications about HZ using the same operational definition from our research team. [ 39 , 40 ] Nevertheless, in this study, the diagnoses of HZ were based on the ICD-9-CM codes, as determined by qualified clinical physicians) for the strictly audited reimbursement process. Furthermore, NHIRD covers a highly representative sample of Taiwan’s general population because the reimbursement policy is universal and operated by a single-buyer, the Taiwanese government.…”

Section: Discussionmentioning

confidence: 99%

Increased risk of herpes zoster in patients with psoriasis: A population-based retrospective cohort study

et al. 2017

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ObjectivesThe risk of herpes zoster (HZ) between patients with psoriasis receiving and not receiving systemic therapy has received increasing attention. This study investigated the association of psoriasis with the risk of HZ.MethodsWe conducted a population-based retrospective cohort study by using the Taiwan National Health Insurance Research Database. The psoriasis cohort consisted of 4077 patients with newly diagnosed psoriasis between 2000 and 2006. Each patient with psoriasis was frequency-matched with four people without psoriasis, by sex, age and index year. (nonpsoriasis cohort; 16308 subjects). Patients who received systemic therapy were classified as having severe psoriasis, whereas those who did not receive systemic therapy were classified as having mild psoriasis. The Cox proportional hazards regression analysis was conducted to estimate the association between psoriasis and HZ risk.ResultsThe overall incidence density rate of HZ in the psoriasis cohort than in the nonpsoriasis cohort (4.50 vs. 3.44 per 1,000 person-years), with a multivariable Cox proportional hazards model measured adjusted HR of 1.29 [95% confidence interval (CI) = 1.07–1.56]. In additional, compared with the nonpsoriasis cohort, the risk of HZ was higher in the severe psoriasis cohort than in the nonpsoriasis cohort (adjusted hazard ratio [HR], 1.61; 95% confidence interval [CI], 1.15–2.27). The comparison between psoriasis and nonpsoriasis cohorts revealed a greatest magnitude risk of HZ in women (adjusted HR, 1.36; 95% CI, 1.04–1.79), study participants in the age group of 20–39 years (adjusted HR, 1.77; 95% CI, 1.17–2.66), and study participants without any comorbidities (adjusted HR, 1.37; 95% CI, 1.02–1.84).ConclusionsOur results suggest that psoriasis is associated with an increased risk of HZ, which involves differences in sex and age. Although systemic therapy may have a major role in the risk of HZ, the intrinsic factors of psoriasis cannot be excluded.

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Section: Discussionmentioning

confidence: 99%

Increased risk of herpes zoster in patients with psoriasis: A population-based retrospective cohort study

et al. 2017

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“…Diabetes, malignancies, chronic kidney disease/uremia, chronic obstructive pulmonary disease, and peptic ulcer disease were all associated with a significantly higher risk of HZ than the general population in most studies (range of HRs: 1.17-8.46) [13,14,18,[20][21][22][23][24][25][26][27]. The potential association was weaker in persons with depression, psychiatric disease, hyperlipidemia, hypertension, as well as those post-general anesthesia (range of HRs: 1.11-1.29) [20,25,26,28,29].…”

Section: The Risk Of Hz In Patients With Other Co-morbiditiesmentioning

confidence: 94%

A systematic literature review to assess the burden of herpes zoster disease in China

Yin

Oorschot

Jiang

et al. 2020

Expert Review of Anti-infective Therapy

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Introduction: Herpes zoster (HZ) or shingles occurs as a result of reactivation after a primary infection with varicella zoster virus (chickenpox). The burden of HZ in older adults in China is not well understood. We conducted a systematic literature review to understand the burden of disease related to HZ, its complications, and associated costs in China. Areas covered: Using publications retrieved from Chinese and English literature databases, we described incidence and prevalence of HZ, occurrence of HZ-related complications, and costs associated with HZ in mainland China, Taiwan, and Hong Kong. Expert opinion: The data, although limited, indicate that the burden of disease due to HZ is substantial in China, with incidence rates that are comparable to the rest of the world. Recently, an adjuvanted recombinant HZ vaccine was approved for use in China. Disease prevention is likely to reduce the burden of disease, with potentially significant economic benefits. However, understanding the public health impact of vaccination in China will require extensive baseline information about incidence, complication rates, and associated costs. This review gives an overview of available research, but also reveals existing gaps. Well-designed observational studies are needed to quantify the total burden of disease and potential impact of prevention through vaccination.

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“…This is supported by recent studies by our group demonstrating a significantly increased risk of zoster among adults24 and children2526 with asthma. Independent studies in England28, Spain29, and Taiwan156 corroborated this finding. As zoster vaccine was approved for adults >50 years of age by the U.S. Food and Drug Administration, consideration for adults with asthma as a target group for the zoster vaccine should be granted.…”

Section: Discussionmentioning

confidence: 76%

Asthma and the Risk of Rheumatoid Arthritis: An Insight into the Heterogeneity and Phenotypes of Asthma

Rolfes

Juhn

et al. 2017

Tuberc Respir Dis

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Asthma is traditionally regarded as a chronic airway disease, and recent literature proves its heterogeneity, based on distinctive clusters or phenotypes of asthma. In defining such asthma clusters, the nature of comorbidity among patients with asthma is poorly understood, by assuming no causal relationship between asthma and other comorbid conditions, including both communicable and noncommunicable diseases. However, emerging evidence suggests that the status of asthma significantly affects the increased susceptibility of the patient to both communicable and noncommunicable diseases. Specifically, the impact of asthma on susceptibility to noncommunicable diseases such as chronic systemic inflammatory diseases (e.g., rheumatoid arthritis), may provide an important insight into asthma as a disease with systemic inflammatory features, a conceptual understanding between asthma and asthma-related comorbidity, and the potential implications on the therapeutic and preventive interventions for patients with asthma. This review discusses the currently under-recognized clinical and immunological phenotypes of asthma; specifically, a higher risk of developing a systemic inflammatory disease such as rheumatoid arthritis and their implications, on the conceptual understanding and management of asthma. Our discussion is divided into three parts: literature summary on the relationship between asthma and the risk of rheumatoid arthritis; potential mechanisms underlying the association; and implications on asthma management and research.

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Adult asthma is associated with an increased risk of herpes zoster: A population-based cohort study

Abstract: Newly diagnosed adult patients with asthma have a significantly higher risk of developing HZ than do those without asthma.

Cited by 27 publications

References 29 publications

Increased risk of herpes zoster in patients with psoriasis: A population-based retrospective cohort study

Increased risk of herpes zoster in patients with psoriasis: A population-based retrospective cohort study

A systematic literature review to assess the burden of herpes zoster disease in China

Asthma and the Risk of Rheumatoid Arthritis: An Insight into the Heterogeneity and Phenotypes of Asthma

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