Adult Atopic Dermatitis with Comorbid Atopic Disease is Associated with Increased Risk of Infections: A Population-Based Cross-Sectional Study

Narala, Saisindhu; Hata, Tissa

doi:10.1007/s13555-017-0172-7

Cited by 14 publications

(13 citation statements)

References 34 publications

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“…Overall, 488 190 patients with AD and 73 334 352 controls were included, with 97 411 patients and 434 225 controls from Europe, 43,44,47–55,57–59,63,68,69,72–75,77,80,83–87,89,91 256 998 patients and 72 674 850 controls from North America, 22,35,39,45,46,64,70,78,90 133 678 patients and 225 420 controls from Asia 41,56,60–62,65–67,71,76,82,83 and 103 patients with AD internationally 88 . Included were 269 861 adults with AD and 718 873 control adults, and 52 530 children with AD and 340 356 control children with AD (five studies did not report age range).…”

Section: Resultsmentioning

confidence: 99%

“…Fifty-one studies were included in this systematic review 22,35,39,41, (Figure 1) and 19 had sufficient data for inclusion in the quantitative metaanalyses. 22,35,39,43,45,46,51,62,64,66,70,[73][74][75][76]78,80,82,90…”

Section: Literature Searchmentioning

confidence: 99%

“…57,60,64,77,80 Nineteen studies included > 50% females, 22,35,39,48,51,54,62,65,66,68,72,[74][75][76][77]82,83,87,88 18 had ≤ 50% females, 44,46,49,50,52,53,[55][56][57][58][59]61,63,67,69,[84][85][86] one all males, 41 one all females, 45 and 12 did not specify sex distribution. 43,47,60,64,70,71,73,78,80,[89]…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The studies were published from 1975 to 2019. Nineteen (37%) were cohort studies, 41,[44][45][46]48,49,52,[56][57][58][59]67,71,74,[82][83][84]86,89 16 (31%) were cross-sectional, 22,35,39,51,60,62,[64][65][66]69,70,73,76,77,90,91 eight (16%) were randomized control trials, 50,[53][54][55]61,72,85,88 seven (14%) were case-control studies 43,47,68,75,78,80,87 and one (2%) was a crossover study. 63 The studies were con...…”

Section: Study Characteristicsmentioning

confidence: 99%

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Association between atopic dermatitis and hypertension: a systematic review and meta‐analysis*

et al. 2021

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Background Previous studies have found conflicting results about the association of atopic dermatitis (AD) with hypertension. Objectives To determine whether AD and AD severity are associated with hypertension. Methods A systematic review was performed of published studies in Ovid MED-LINE, Embase, Scopus, Web of Science, and GREAT (Global Resource for EczemA Trials) databases. At least two reviewers conducted title/abstract, full-text review and data extraction. Quality of evidence was assessed using the Newcastle-Ottawa Scale.Results Fifty-one studies met the inclusion criteria and 19 had sufficient data for meta-analysis. AD was associated with higher odds of hypertension compared with healthy controls [increased in nine of 16 studies; pooled prevalence 16Á4% vs. 13Á8%; random-effects regression, pooled unadjusted odds ratio (OR) 1Á16, 95% confidence interval (CI) 1Á04-1Á30], but lower odds of hypertension compared with psoriasis [decreased in five of eight studies; 15Á4% vs. 24Á8% (OR 0Á53, 95% CI 0Á37-0Á76)]. In particular, moderate-to-severe AD was associated with hypertension compared with healthy controls [increased in four of six studies; 24Á9% vs. 14Á7% (OR 2Á33, 95% CI 1Á10-4Á94)]. Hypertension was commonly reported as an adverse event secondary to AD treatments, particularly systemic ciclosporin A. Limitations include lack of longitudinal studies or individual-level data, and potential confounding. Conclusions AD, particularly moderate-to-severe disease, was associated with increased hypertension compared with healthy controls, but with lower odds than for psoriasis.What is already known about this topic?• Previous studies have showed conflicting results regarding the association between atopic dermatitis (AD) and hypertension.

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Section: Resultsmentioning

confidence: 99%

Section: Literature Searchmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

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Association between atopic dermatitis and hypertension: a systematic review and meta‐analysis*

et al. 2021

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“…Most AD occurs before 1 year of age, and it is generally considered as the first sign of the development of allergic diseases, including asthma, allergic rhinitis and conjunctivitis [ 17 , 18 ]. The prevalence of AD ranges from 2.4% to 37% in children and 6.8%–10.6% in adults worldwide [ 19 , 20 ], and was 12.9% in children aged 1–7 years in China in a previous study [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and childhood atopic dermatitis: a prospective birth cohort study

Chen

Huang

et al. 2018

Environ Health

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BackgroundPerfluoroalkyl and polyfluoroalkyl substances (PFASs) have been reported to suppress immune function. However, previous studies on prenatal exposure to PFASs and allergic disorders in offspring provided inconsistent results. We aimed to examine the association between prenatal exposure to PFASs and childhood atopic dermatitis (AD) in offspring up to 24 months of age.MethodsA prospective birth cohort study involving 1056 pregnant women was conducted in two hospitals in Shanghai from 2012 to 2015. Prenatal information was collected by an interview with the women and from medical records. Fetal umbilical cord blood was collected at birth. Cord blood plasma PFASs were measured. Children were followed at 6, 12 and 24 months and information on the development of AD was recorded. AD was diagnosed by 2 dermatologists independently based on the questionnaires. Multiple logistic regression was used to compute odds ratio (OR) and corresponding 95% confidence interval (CI) for the association between AD and each PFASs, adjusting for potential confounders.ResultsA total of 687 children completed a 2-year follow-up visit and had PFASs measurement. AD was diagnosed in 173 (25.2%) children during the first 24 months. In female children, a log-unit increase in perfluorooctanoic acid (PFOA) was associated with a 2.1-fold increase in AD risk (AOR 2.07, 95% CI 1.13–3.80) after adjusting for potential confounders. The corresponding risk was 2.22 (1.07–4.58) for perfluorononanoic acid (PFNA). The highest PFOA quartile was significantly associated with AD (2.52, 1.12–5.68) compared with the lowest quartile. The highest quartile of PFNA, perfluorodecanoic acid (PFDA) and perfluorohexane sulfonic acid (PFHxS) were associated with AD with AOR (95% CI) being 2.14 (0.97–4.74), 2.14 (1.00–4.57), and 2.30 (1.03–5.15), respectively. Additionally, the second quartile of perfluorododecanoic acid (PFDoA) was associated with a 3.2-fold increase in AD risk (3.24, 1.44–7.27). However, no significant associations were found in male children.ConclusionsPrenatal exposure to PFOA, PFDA, PFDoA and PFHxS significantly increased the risk of childhood AD in female children during the first 24 months of life. In addition, the associations between AD with prenatal exposure to PFNA were close to statistical significance.Electronic supplementary materialThe online version of this article (10.1186/s12940-018-0352-7) contains supplementary material, which is available to authorized users.

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Prevalence, incidence and relative risk of cardiovascular disease risk factors in adults with atopic dermatitis: A systematic review

Thyssen

Terres

Pierce

et al. 2023

JEADV Clinical Practice

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Atopic dermatitis (AD) has been associated with cardiovascular disease (CVD). A better understanding of CVD risk factors in AD populations may help dermatologists better counsel their patients regarding potential risks and treatment choices. This systematic literature review evaluated the prevalence, absolute risk (i.e., incidence) and relative risk of CVD risk factors in adults with AD. MEDLINE, Embase and The Cochrane Library were searched for English‐language articles published between January 2005 and the search date (16–17 March 2021) using terms for AD, prevalence/risk and CVD risk factors. Observational studies that reported the prevalence, absolute risk and/or relative risk of CVD risk factors in adults with AD were eligible. Of the 1277 unique articles identified, 71 met the inclusion criteria. Most studies were cross‐sectional or retrospective cohort studies from Europe, North America or Asia; many used national databases. Studies were heterogeneous, with inconsistent definitions of AD and risk factors (especially smoking and obesity), different methodologies and different populations (e.g., ethnicity). Within most controlled studies, the prevalence of several risk factors, particularly obesity, hypertension and dyslipidemia, was higher for AD than for controls. Where assessed, the prevalence of most CVD risk factors increased with increasing AD severity. Relative risks varied across studies. Only nine studies reported the temporal relationship between AD and CVD risk factors. Six studies reported absolute or relative risk of developing CVD risk factors (diabetes, hypertension and smoking) in AD populations; only one of these reported an elevated risk (hypertension). Despite the high number of studies to date, conclusive data regarding the relationship between AD and many CVD risk factors are lacking, and additional, carefully designed, prospective studies are required.

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Adult Atopic Dermatitis with Comorbid Atopic Disease is Associated with Increased Risk of Infections: A Population-Based Cross-Sectional Study

Cited by 14 publications

References 34 publications

Association between atopic dermatitis and hypertension: a systematic review and meta‐analysis*

Association between atopic dermatitis and hypertension: a systematic review and meta‐analysis*

Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and childhood atopic dermatitis: a prospective birth cohort study

Prevalence, incidence and relative risk of cardiovascular disease risk factors in adults with atopic dermatitis: A systematic review

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