Adult attention-deficit hyperactivity disorder is associated with alterations in circadian rhythms at the behavioural, endocrine and molecular levels

Baird, Alison L.; Coogan, Andrew N.; Siddiqui, Alina; Donev, Rossen; Thome, Johannes

doi:10.1038/mp.2011.149

Cited by 199 publications

(180 citation statements)

References 29 publications

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“…Por último, los trastornos de sueño se anales de psicología, 2014, vol. 30, nº 3 (octubre) han relacionado con mutaciones en los genes Per2 y Per3 (Cermakian y Boivin, 2003) y el TDAH con mutaciones en el gen Per2 (Baird, Coogan, Siddiqui, Donev y Thome, 2012).…”

Section: Discussionunclassified

Tipología circadiana y problemas de salud mental

Antúnez¹,

Navarro²,

Adán³

2014

analesps

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Resumen: La tipología circadiana (matutina, vespertina o intermedia) es una diferencia individual que se ha relacionado con numerosos aspectos de la salud mental. En este estudio se revisan los principales hallazgos publicados en el área. Tras la búsqueda bibliográfica en las principales bases de datos se seleccionaron un total de 70 artículos publicados en castellano e inglés entre los años 1990 y 2012, recogidos en las bases de datos ISI, Scopus y Medline, donde se muestra que los individuos vespertinos presentan una mayor prevalencia de trastorno afectivo estacional, depresión mayor, trastorno bipolar, esquizofrenia, trastornos de la conducta alimentaria, trastornos del sueño, conductas adictivas, TDAH y mayores niveles de ansiedad que los matutinos. La tipología vespertina se perfila como un factor de riesgo y la matutina como un factor protector para el desarrollo de diversas psicopatologías, apuntándose como posibles causas polimorfismos de los genes reloj, el jet-lag social y algunos rasgos de personalidad. La tipología circadiana debe considerarse en la evaluación, tratamiento y prevención de las psicopatologías, pues afecta al inicio, curso, remisión y recaída de las mismas. La utilización de terapia cronobiológica es un factor a tener en cuenta en el abordaje terapéutico cuando la expresión rítmica circadiana se halla alterada. Palabras clave: revisión sistemática cualitativa; tipología circadiana; matutinidad-vespertinidad; salud mental; psicopatología. Title:Circadian typology and problems in mental health. Abstract: Circadian typology (morning-type, neither-type, and eveningtype) is an individual difference which has been related to numerous aspects of mental health. In this paper we present a review of the findings published on this topic. After searching in the main databases a total number of 70 works were selected, published in Spanish and English from 1990 to 2012 collected in the databases ISI, Scopus and Medline. These works show that individuals with evening-type typology exhibit a greater prevalence of seasonal affective disorder, mayor depression, bipolar disorder, schizophrenia, eating disorders, sleep disorders, addictive behaviours, ADHD, and higher anxiety levels than morning-type typology individuals. In this sense, the evening-type is considered as a factor of risk whereas the morning-type would be a protective factor for the development of several mental disorders. This could be a result of clock gene polymorphisms, social jet lag and some personality traits. Circadian typology must be considered in the evaluation, treatment and prevention of the mental disorders, as it affects to the start, course, remission and relapse of diverse problems of mental health. Chronobiological therapy must be also considered in the therapeutic approaching when the circadian rhythmical expression is altered. Key words: qualitative systematic review; circadian typology; morningnesseveningness; mental health; psychopathology. IntroducciónLos ritmos circadianos, descritos por de Mairan en 1729 (como se ci...

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Section: Discussionunclassified

Tipología circadiana y problemas de salud mental

Antúnez¹,

Navarro²,

Adán³

2014

analesps

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“…Of note, adult ADHD is linked with blunted Per2 expression (Baird et al, 2012). It is also interesting that the other clock genes with altered circadian profiles in ENT1 KO mice, Clock and Dbp, are associated with ADHD (Kissling et al, 2008;Roybal et al, 2007;Xu et al, 2010), bipolar disorder (Le-Niculescu et al, 2008;Lee et al, 2010;Shi et al, 2008;Soria et al, 2010), anxiety (Le-Niculescu et al, 2011a), and AUD (Le-Niculescu et al, 2011b;Le-Niculescu et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Adenosinergic Regulation of Striatal Clock Gene Expression and Ethanol Intake During Constant Light

Ruby

Vadnie

Hinton

et al. 2014

Neuropsychopharmacol

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Circadian rhythm and sleep disruptions occur frequently in individuals with alcohol use disorders (AUD) and present significant barriers to treatment. Recently, a variant of adenosine transporter, equilibrative nucleoside transporter 1 (ENT1), was associated with the cooccurrence of sleep problems and AUD. We have previously shown that mice lacking ENT1 (ENT1 KO) have reduced adenosine levels in the striatum and drink more alcohol compared with wild types (WT). However, it is unknown whether ENT1 deletion disrupts circadian rhythms, which may contribute to alcohol preference in ENT1 KO mice. Here we used these mice to determine whether endogenous adenosine regulates circadian genetic and behavioral rhythms and influences alcohol intake during chronodisruption. We examined circadian locomotor activity in ENT1 KO vs WT littermates and found that ENT1 KO mice were both active earlier and hyperactive compared with WT mice at night. We used real-time PCR and immunohistochemistry to estimate striatal clock gene levels and found that PER2 expression in the striatum was blunted by ENT1 deletion or A2A receptor (A2AR) antagonism. Next, we exposed ENT1 KO and WT mice to constant light (LL) and found further elevation in ethanol intake in ENT1 KO, but not in WT mice, supporting the notion that circadian dysfunction may contribute to increased alcohol intake in ENT1 KO mice. Finally, we showed that A2AR agonist administration normalized PER1 and PER2 expression and circadian locomotor activity in ENT1 KO mice. Together, our results demonstrate that adenosine signaling regulates cellular and behavioral circadian timing and influences alcohol intake during chronodisruption.

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“…While clock gene variants are not among the strongest associations with ADHD found by GWAS, clock gene variants may be enriched among weaker GWAS associations [58]. A gene expression study from subjects with adult ADHD revealed a number of alterations in molecular rhythms [66], including loss of BMAL and PER2 expression rhythms in oral mucosal cells, blunted melatonin rhythms, and 3 hr phase delays in cortisol rhythms relative to controls. Consistent with previous behavioral reports, the same study also found high levels of activity at night, greater evening preference, and long latency to sleep onset.…”

Section: Attention Deficit Hyperactivity Disorder (Adhd)mentioning

confidence: 99%

Circadian Clock and Stress Interactions in the Molecular Biology of Psychiatric Disorders

Landgraf

McCarthy

Welsh

2014

Curr Psychiatry Rep

149

100

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Many psychiatric disorders are characterized by circadian rhythm abnormalities including disturbed sleep/wake cycles, changes in locomotor activity, and abnormal endocrine function. Animal models with mutations in circadian "clock genes" commonly show disturbances in reward processing, locomotor activity and novelty seeking behaviors, further supporting the idea of a connection between the circadian clock and psychiatric disorders. However, if circadian clock dysfunction is a common risk factor for multiple psychiatric disorders, it is unknown if and how these putative clock abnormalities could be expressed differently, and contribute to multiple, distinct phenotypes. One possible explanation is that the circadian clock modulates the biological responses to stressful environmental factors that vary with an individual's experience. It is known that the circadian clock and the stress response systems are closely related: Circadian clock genes regulate the physiological sensitivity to, and rhythmic release of glucocorticoids (GC). In turn, GCs have reciprocal effects on the clock. Since stressful life events or increased vulnerability to stress are risk factors for multiple psychiatric disorders including posttraumatic stress disorder (PTSD), attention deficit hyperactivity disorder (ADHD), bipolar disorder (BD), major depressive disorder (MDD), alcohol use disorder (AUD) and schizophrenia (SCZ), we propose that modulation of the stress response is a common mechanism by which circadian clock genes affect these illnesses. Presently, we review how molecular components of the circadian clock may contribute to these six psychiatric disorders, and present the hypothesis that modulation of the stress response may constitute a common mechanism by which the circadian clock affects multiple psychiatric disorders.

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Adult attention-deficit hyperactivity disorder is associated with alterations in circadian rhythms at the behavioural, endocrine and molecular levels

Cited by 199 publications

References 29 publications

Tipología circadiana y problemas de salud mental

Tipología circadiana y problemas de salud mental

Adenosinergic Regulation of Striatal Clock Gene Expression and Ethanol Intake During Constant Light

Circadian Clock and Stress Interactions in the Molecular Biology of Psychiatric Disorders

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