Adult Atypical Teratoid/Rhabdoid Tumor in the Pineal Region: Case Report and Literature Review

Monteiro, Joana; Santiago, Bruno; Manilha, Rui; Viegas, Catarina; Oliveira, Ana; Sá, Manuel Cunha e

doi:10.1016/j.wneu.2019.11.075

Cited by 6 publications

(3 citation statements)

References 27 publications

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“…As described in Table 1, these three cases of adult-onset AT/RT arising from the cranial nerves were also negative for expression of INI-1 protein. Consistent with previous reports (8,12), the tumor was also positive for SMA, VIM, CD99, and EMA expression, and negative for desmin, S100, and GFAP expression. Classical immunohistochemical profiles have a high predictive value for differential diagnosis of other brain tumors (8).…”

Section: Discussionsupporting

confidence: 92%

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Atypical Teratoid/Rhabdoid Tumor Originated From the Trigeminal Nerve in a Young Male Adult: Case Report and Review of the Literature

Chen

Mei

et al. 2020

Front. Neurol.

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Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant central nervous system neoplasm predominantly found in children under the age of 3 years, and is extremely rare in adults. There is no specific clinical presentations or radiological features in reported cases of AT/RT. Diagnosis of brain AT/RT is mainly dependent on the classical pathological characteristics. We report a rare case of AT/RT arising from the trigeminal nerve and leading to progressively multiple cranial nerve palsies in a 25-year-old male patient. Microsurgical resection of the tumor has been performed and confirmed the diagnosis by postoperative pathology. To our knowledge, this is the second case of adult-onset AT/RT originating from the trigeminal nerve.

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Section: Discussionsupporting

confidence: 92%

“…The patients suffer a poor clinical outcome regardless of their age and gender (11). To date, a total of nearly 55 adult AT/RTs have been reported in the literature (12). Only one of them originated from the trigeminal nerve (9), and this young adult reported here belongs to another one.…”

Section: Discussionmentioning

confidence: 79%

Atypical Teratoid/Rhabdoid Tumor Originated From the Trigeminal Nerve in a Young Male Adult: Case Report and Review of the Literature

Chen

Mei

et al. 2020

Front. Neurol.

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“…Atypical teratoid/rhabdoid tumor of the pineal region in adults was first reported in 1999 by Sugita et al 7 as a pineal malignant rhabdoid tumor; thereafter, only nine cases have been reported to date, making our patient 10th in the list (Table 2 ). 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 Considering the radiographic images, adult pineal AT/RT examined by Kanoto et al 15 in 2015 was considered to be the same as the case reported by Kuge et al 11 in 2012; therefore, it was counted as one case. The age of these patients ranged from 19 to 45 years and comprised four men and six women.…”

Section: Discussionmentioning

confidence: 99%

A case of an atypical teratoid/rhabdoid tumor with distinctive histology in the pineal region in an adult patient

Doi

Koike

Yoshida

et al. 2021

Pathology International

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A 31‐year‐old man suffered from headaches and presented at a hospital after the symptom worsened. Obstructive hydrocephalus and a pineal tumor were identified, and he was transferred to our hospital for further investigation and treatment. Cranial computed tomography revealed a hypodense mass lesion on the right of the pineal region, and calcifications and enlargement of the lateral and third cerebral ventricles were also evident. Blood tests were negative for all tumor markers. Laparoscopic biopsy and third‐ventricle fenestration were performed that day as an emergency surgery to treat the obstructive hydrocephalus. Postoperative cranial magnetic resonance imaging revealed a solid tumor that was hypointense on T1‐weighted imaging, hyperintense on T2‐weighted imaging, and heterogeneously enhanced by Gd. Subsequently, the tumor increased in size, and craniotomy and tumorectomy were performed. Histologically, the tumor proliferated as round or short spindle‐shaped cells in a myxoid matrix, forming arrays that surrounded the blood vessels. As a few cells with eosinophilic cytoplasm were also present and immunostaining for INI‐1 was negative, the patient was diagnosed with atypical teratoid/rhabdoid tumor (AT/RT). AT/RT of the pineal region in adults is rare, and herein, we report the morphological characteristics of this case and reviewed the relevant literature.

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Desmoplastic myxoid tumor, SMARCB1-mutant: a new variant of SMARCB1-deficient tumor of the central nervous system preferentially arising in the pineal region

et al. 2021

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Adult Atypical Teratoid/Rhabdoid Tumor in the Pineal Region: Case Report and Literature Review

Cited by 6 publications

References 27 publications

Atypical Teratoid/Rhabdoid Tumor Originated From the Trigeminal Nerve in a Young Male Adult: Case Report and Review of the Literature

Atypical Teratoid/Rhabdoid Tumor Originated From the Trigeminal Nerve in a Young Male Adult: Case Report and Review of the Literature

A case of an atypical teratoid/rhabdoid tumor with distinctive histology in the pineal region in an adult patient

Desmoplastic myxoid tumor, SMARCB1-mutant: a new variant of SMARCB1-deficient tumor of the central nervous system preferentially arising in the pineal region

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