Adult Brain Cancer in the U.S. Black Population: A Surveillance, Epidemiology, and End Results (SEER) Analysis of Incidence, Survival, and Trends

Abstract

BackgroundDespite much epidemiological research on brain cancer in the United States, the etiology for the various subtypes remains elusive. The black population in the United States currently experiences lower incidence but higher survival rates when compared to other races. Thus, the aim of this study is to analyze the trends in incidence and survival for the 6 most common primary brain tumors in the black population of the United States.Material/MethodsThe Surveillance, Epidemiology, and End Results (SEER) database was utilized in this study to analyze the incidence and survival rates for the 6 most common brain tumor subtypes. Joinpoint 3.5.2 software was used to analyze trends in the incidence of diagnosis from 1973 to 2008. A Kaplan-Meier curve was generated to analyze mean time to death and survival at 60 months.ResultsJoinpoint analysis revealed that per year the incidence of brain cancer in the U.S. black population increased by 0.11 between 1973 and 1989. After this period, a moderate decrease by 0.06 per annum was observed from 1989 to 2008. Lymphoma was the most common primary tumor subtype for black individuals ages 20–34, and glioblastoma was identified as the most common tumor subtype for black individuals in the age groups of 35–49, 50–64, 65–79, and 80+.ConclusionsThis population-based retrospective study of brain cancer in black adults in the United States revealed significant sex and age differences in the incidence of the 6 most common brain tumor subtypes from 1973 to 2008.

Association between giant cell glioblastoma and glioblastoma multiforme in the United States: A retrospective cohort study

“…males are afflicted with GBM than with GCG, while more females are afflicted with GCG (p = .481), consistent with (Colen, Wang, Singh, Gutman, & Zinn, 2015;Matsuda et al, 2011;Nizamutdinov et al, 2018;Ohgaki et al, 2004;Shinojima et al, 2004;Verger et al, 2011). Another study, conducted on Black patients with GBM, showed that Black males were affected by GBM more than were Black females (Loukas, 2014). Therefore, GCG, an uncommon type of glioblastoma multiforme, more often affects females.…”

“…Therefore, age is considered a significant predictor of survival time (Shah, Bista, & Sharma, 2016). Another study, conducted on Black patients with GBM, showed that Black males were affected by GBM more than were Black females (Loukas, 2014). This finding may indicate that the elderly population is more susceptible to GBM due to an increased chance that cells will mutate into cancer cells.…”

CHL1 Is Expressed and Functions as a Malignancy Promoter in Glioma Cells

“…Gliomas are a set of highly invasive glial cell-derived tumors that originate in the central nervous system, and they account for 40% to 50% of all intracranial tumors (Gabriel et al, 2014 ). Despite advancements in surgery, chemotherapy and radiation oncology technology, the average survival time is 9.7 months.…”

Incidence Rates in Low-Grade Primary Brain Tumors: Are There Differences Between Men and Women? A Systematic Review

“…When analyzing the period of 1998 - 2008, the average male incidence decreased to 0.31 per 100,000 compared to the female incidence of 0.18 per 100,000, which was stated as a “sizable difference”. No incidence rate ratio (IRR) was calculated, nor any statistical power in the differences between the genders [ 28 ].…”