Adult Burkitt-like lymphoma of the colon: a case report and a review of the literature

Chehab, Bassem; Schulz, Thomas; Nassif, Imad

doi:10.1016/j.gie.2007.10.022

Cited by 9 publications

(6 citation statements)

References 16 publications

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“…Despite the highly aggressive nature of BL, these tumors tend to be exceptionally chemosensitive and potentially curable with appropriate combination chemotherapy [ 2 ]. As BL can involve the CNS in a significant proportion of cases, systemic treatment is combined with instillation of intrathecal chemotherapy for CNS prophylaxis [ 2 , 4 ]. As a result of BL’s high aggression and sensitivity to chemotherapy, patients can develop tumor lysis syndrome after the initiation of treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Surgical removal of the tumor is not typically necessary and radiotherapy has not been shown to improve survival. However, surgical management of BL may be indicated to establish diagnosis, or in instances of obstruction, perforation, fistula formation or uncontrollable hemorrhage [ 4–6 ]. Some studies in the pediatric population have argued for localized resection in patients with intra-abdominal BL who present with limited disease [ 7–9 ].…”

Section: Discussionmentioning

confidence: 99%

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Resection of a colonic mass following trauma: a diagnostic dilemma

Burchard

Thomay

2020

Journal of Surgical Case Reports

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A 53-year-old Caucasian male presented with a 2-week history of abdominal distension, pain, nausea and lethargy. His symptoms began 1 day after an all-terrain vehicle accident during which he suffered blunt-force trauma to his mid-right abdomen. CT scan demonstrated abnormal thickening of the ascending colon and terminal ilium with surrounding inflammation within the retroperitoneum and colonic mesentery. Given his likely mechanism and symptomatic improvement, he was initially managed conservatively. However, he was readmitted with recurrence of symptoms, and a repeat CT scan demonstrated no interval improvement. An exploratory laparotomy was performed and a firm, fixed mass of the right-colon and colonic mesentery was found. Final histopathology of the mass revealed a diffuse lymphoid infiltrate with numerous mitotic figures and apoptotic cells. Immunohistochemical staining was positive for CD45, CD20, CD10, and BCL-6 and negative for CD3, TdT, and BCL-2, indicating a diagnosis of Burkitt lymphoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Resection of a colonic mass following trauma: a diagnostic dilemma

Burchard

Thomay

2020

Journal of Surgical Case Reports

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“…The clinical symptoms of sporadic BL are various, including abdominal pain, nausea, vomiting, bowel obstruction, ascites, abdominal distention, melena, and hematochezia, and may also mimic signs of acute appendicitis or intussusception [1,2,[6][7][8]. Other involvement of sporadic BL includes bone marrow, central nervous system, kidney, testis, ovary, and breast [6,9,10], and may present with symptoms related to these systems. In comparison, endemic BL is commonly observed in African children of four to seven years, with frequent involvement of the jaw and kidneys [2,5,10].…”

Section: Primarymentioning

confidence: 99%

“…Other involvement of sporadic BL includes bone marrow, central nervous system, kidney, testis, ovary, and breast [6,9,10], and may present with symptoms related to these systems. In comparison, endemic BL is commonly observed in African children of four to seven years, with frequent involvement of the jaw and kidneys [2,5,10]. The combination of the symptoms mentioned above can lead to false diagnoses and delayed treatment.…”

Section: Primarymentioning

confidence: 99%

Burkitt’s Lymphoma of the Colon: A Case Report and Review of the Texas Cancer Registry

Sato¹,

Hock²,

Garcia³

et al. 2022

Cureus

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Burkitt's lymphoma (BL) is an aggressive form of non-Hodgkin's B-cell lymphoma with gastrointestinal (GI) involvement, but very few cases report primary colonic findings. We report one case of primary sporadic BL of the colon with non-specific GI symptoms, and its morphologic and immunohistochemical features. In addition, we reviewed and analyzed data from the Texas Cancer Registry between the years 1995 and 2016 in order to provide insight into the demography and epidemiology of BL originating in the colon.This paper reports a 69-year-old male who presented with a history of irritable bowel syndrome, was diagnosed with BL in the colon, and subsequently developed abdominal compartment syndrome. Biopsies derived from the colon tumor at three different sites showed infiltrating malignant lymphoma of the lamina propria. Immunohistochemistry stains of lymphoma cells were positive for CD20, CD79a, CD10, MUM1, BCL6, C-MYC, and negative for BCL2, cyclin D1, CD5, and CD3. Ki-67 demonstrated a high proliferative index of 100%. Forty-nine cases of primary BL of the colon were reported to the Texas Cancer Registry between 1995 and 2016. The unadjusted incidence of BL originating in the colon in persons 18 years old and over was 1.32 per 10 million, and the majority of the cases involved non-Hispanic white males with cecum being the most common primary site. BL is a rapidly growing malignancy, hence, reporting cases of BL and its presenting symptoms can improve assessment and management. Our analysis from the Texas Cancer Registry further supports the rarity of primary sporadic BL in the colon.

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“…The clinical variants are endemic, sporadic, and immunodeficiency-associated types. [1] The endemic form often involves the maxilla or mandible and sporadic form presents commonly with abdominal swelling, often at the ileocaecal region. In adults, Burkitt's lymphoma frequently involves the liver and bone marrow.…”

Section: Introductionmentioning

confidence: 99%

Imaging of Burkitt′s lymphoma-abdominal manifestations

2013

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Burkitt's lymphoma is an uncommon form of non-Hodgkin lymphoma in adults. The diagnostic workup for Burkitt's lymphoma includes radiological imaging and like any other form of non-Hodgkin's lymphoma definitive diagnosis is by histopathology. Imaging is necessary to determine the distribution and severity in terms of extent and organs of involvement to further assist in staging and thence to implement appropriate therapy. High incidence of intraabdominal involvement is seen in American Burkitt lymphoma.

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Adult Burkitt-like lymphoma of the colon: a case report and a review of the literature

Cited by 9 publications

References 16 publications

Resection of a colonic mass following trauma: a diagnostic dilemma

Resection of a colonic mass following trauma: a diagnostic dilemma

Burkitt’s Lymphoma of the Colon: A Case Report and Review of the Texas Cancer Registry

Imaging of Burkitt′s lymphoma-abdominal manifestations

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