Adult cardiovascular risk factors in premature babies

Irving, John; Belton, N. R.; Elton, R. A.; Walker, Brian R.

doi:10.1016/s0140-6736(00)02384-9

Cited by 235 publications

(203 citation statements)

References 3 publications

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“…Similar findings were reported in a study of young adults; a lower GFR, higher serum creatinine and microalbuminaria was reported at 19 years of age in subjects born at <32 weeks gestation (and also small for gestational age) [54]. Furthermore, there is strong epidemiological evidence to link premature birth with the development of hypertension [58][59][60][61][62][63] and increased cardiovascular risk during adulthood [64,65]. This 'risk' may be further exacerbated in the presence of impaired renal function, possibly leading to hypertension, and the possible development of cardiovascular disease in later life [66].…”

Section: Renal Functionsupporting

confidence: 81%

Preterm Birth and/or Factors that Lead to Preterm Delivery: Effects on the Neonatal Kidney

Ryan¹,

Black²

2015

J Neonatal Biol

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Preterm birth (defined as birth prior to 37 completed weeks of gestation), occurs in approximately 10% of all births and is one of the leading causes of neonatal morbidity and mortality worldwide. Preterm infants are born at a time when kidney development is still ongoing, and consequently can lead to renal impairment (in both the short-term and long-term), as well as severe glomerular abnormalities in some preterm infants. Since the glomerular abnormalities are not present in all preterm kidneys, this suggests that it is not preterm birth per se that leads to the glomerular abnormalities but may relate to factors associated with the etiology of the premature delivery, or factors in neonatal care. In this review, we provide an overview of what is currently known of how prenatal and postnatal factors can potentially impact on the immature kidneys of infants born preterm.

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Section: Renal Functionsupporting

confidence: 81%

Preterm Birth and/or Factors that Lead to Preterm Delivery: Effects on the Neonatal Kidney

Ryan¹,

Black²

2015

J Neonatal Biol

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“…Babies born prematurely also had trends for an adverse metabolic profile and were at risk for hypertension and hyperglycemia as adults. Infants with IUGR were not measurably more disadvantaged than preterm infants with birth weight appropriate for gestational age (Irving et al 2000).…”

Section: The Impact Of Fetal Environment and Prematurity On Adult Heamentioning

confidence: 92%

“…Babies born prematurely, whether or not they have intrauterine growth restriction (IUGR), are also at risk as adults for poor cardiovascular health outcomes (Irving et al 2000). In a study of mothers of 72 LBW and 54 NBW infants born in Edinburgh between November 1973 andFebruary 1975, LBW premature babies had higher adult blood pressure and fasting plasma glucose than NBW controls born at term.…”

Section: The Impact Of Fetal Environment and Prematurity On Adult Heamentioning

confidence: 99%

Life Course Health Development Outcomes After Prematurity: Developing a Community, Clinical, and Translational Research Agenda to Optimize Health, Behavior, and Functioning

Msall

Sobotka

Dmowska

et al. 2017

Handbook of Life Course Health Development

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Long-term survival for infants born extremely prematurely (<28 weeks of gestation) and extremely low birth weight (<1000 g) has increased dramatically due to obstetrical and neonatal advances. However, poverty, inequality, and resulting health disparities are significant contributors to women who give birth to preterm infants and also impact their children’s healthy development and education. While the vast majority of survivors of extreme prematurity do not have the most severe forms of neurodevelopmental disability (i.e., cerebral palsy, blindness, sensorineural hearing loss >55 dB, and intellectual disability), half of survivors can be expected to require special education services at kindergarten entry and during their school years. In addition, there are also high rates of health disparities in the prevalence of preterm birth across the spectrum of gestations including very preterm (28–31 weeks), moderate preterm (32–33 weeks), and late preterm births (34–36 weeks). Life course health development offers a valuable framework for examining how complex medical and social adversities that impact a mother’s health can also impact their child’s health and developmental trajectories. A better understanding of the cumulative impact of protective factors and other buffers that can support prenatal and postnatal parental and child health will provide important insights into how to promote greater resiliency and optimal health development. This population-based information can provide ongoing data for thriving developmental health trajectories for vulnerable preterm survivors with respect to physical, behavioral, and social health outcomes. Though premature infants who receive comprehensive early intervention and preschool educational supportive services have improved outcomes at kindergarten entry, school-age survivors, even those escaping major neurodevelopmental diagnoses, have challenges which impact attention, behavioral regulation, academic achievement, and social skills compared to their full-term peers. Unfortunately, many essential services that can contribute to better outcomes are unnecessarily fragmented and not systematically implemented to provide preventive interventions that optimize health, learning, executive function, social, and adaptive competencies. These cumulative medical, developmental, and social risks among preterm survivors adversely impact long-term adult physical and behavioral health, educational attainment, and social participation. In order to address these disparities, more precise, population-based, health development interventions aimed at optimizing physical and behavioral health, educational achievement, and adaptive competencies will be required. We recommend research strategies to inform our efforts for improving life course outcomes.

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“…Des anomalies des épreuves fonctionnelles respiratoires persistent à l'âge adulte [11]. 3 Enfants dont le développement est normal.…”

Section: Revuesunclassified

“…De ce fait, le concept de la programmation périnatale dans le contexte de la prématurité a été dans un premier temps sous-estimé. À la lumière des données actuelles sur le devenir à long terme de ces enfants, il apparaît clairement que la grande prématurité est un facteur de risque, indépendamment du poids de naissance, de la programmation de maladies chroniques de l'adulte [3]. L'incidence de la prématurité et du retard de croissance intra-utérin témoigne de l'ampleur des risques liés à la programmation des maladies chroniques de l'adulte.…”

Section: Revuesunclassified

DOHaD : conséquences à long terme de la pathologie périnatale

et al. 2016

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Adult cardiovascular risk factors in premature babies

Abstract: Among babies born at term, low birthweight predicts cardiovascular risk factors and disease in adulthood. This study shows that babies born prematurely, whether or not they have intrauterine growth retardation, are predisposed to similar risks as adults.

Cited by 235 publications

References 3 publications

Preterm Birth and/or Factors that Lead to Preterm Delivery: Effects on the Neonatal Kidney

Preterm Birth and/or Factors that Lead to Preterm Delivery: Effects on the Neonatal Kidney

Life Course Health Development Outcomes After Prematurity: Developing a Community, Clinical, and Translational Research Agenda to Optimize Health, Behavior, and Functioning

DOHaD : conséquences à long terme de la pathologie périnatale

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