Adult Chronic Rhinosinusitis: Definitions, Diagnosis, Epidemiology, and Pathophysiology

Benninger, Michael S.; Ferguson, Berrylin J.; Hadley, James A.; Hamilos, Daniel L.; Jacobs, Michael; Kennedy, David W.; Lanza, Donald C.; Marple, Bradley F.; Osguthorpe, J. David; Stankiewicz, James A.; Anon, Jack B.; Denneny, James C.; Emanuel, Ivor A.; Levine, Howard L.

doi:10.1016/s0194-5998(03)01397-4

Cited by 607 publications

(164 citation statements)

References 146 publications

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“…In brief, 22 of 34 CRS patients had NP (group CRS-NP) and the remainder (n = 12) had no visible polyps in the middle meatus (group CRS). CRS and CRS-NP were defined using the diagnostic criteria established by Benninger et al [1]. Nine patients were asthmatic, and all of them had NP.…”

Section: Methodsmentioning

confidence: 99%

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Expression and Characterization of PGD2 Receptors in Chronic Rhinosinusitis: Modulation of DP and CRTH2 by PGD2

Yamamoto¹,

Okano²,

Fujiwara³

et al. 2008

Int Arch Allergy Immunol

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Background: Prostaglandin D₂ (PGD₂) participates in airway inflammation. We reported that levels of hematopoietic-type PGD₂ synthase (h-PGDS) in sinonasal tissues may play an important role in the pathophysiology of chronic rhinosinusitis (CRS). Two PGD₂ receptors have been isolated, DP and CRTH2, but whether they participate in CRS remains unclear. We sought to determine the expression and characterization of DP and CRTH2 in CRS. Methods: Expression of DP and CRTH2 in nasal polyps (NP) and uncinate process mucosae (UPM) was examined by in situ hybridization and immunohistochemistry and evaluated by real-time quantitative PCR. h-PGDS, IL-5, eotaxin and RANTES expression was also determined. In addition, the effect of PGD₂ on the expression of both receptors in UPM was assessed. Results: DP was widely expressed, not only in infiltrating inflammatory cells but also in constitutive cells such as vascular endothelial cells and ciliated columnar epithelia. CRTH2 was selectively expressed in inflammatory cells and some glands. Significantly greater levels of DP mRNA and conversely decreased levels of CRTH2 mRNA were observed in NP compared with UPM. DP and CRTH2 mRNA levels were not only positively and inversely correlated with levels of h-PGDS but also with eotaxin, respectively. Furthermore, addition of PGD₂ significantly increased DP expression and conversely reduced CRTH2 expression in UPM. Conclusions: These results suggest that distinct expression of DP and CRTH2 is associated with the pathophysiology of CRS, including NP formation, and the expression of these receptors may be regulated by h-PGDS and PGD₂.

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Section: Methodsmentioning

confidence: 99%

“…Chronic rhinosinusitis (CRS), one of the most common chronic airway inflammations, contains a group of disorders with and without nasal polyps (NP) [1]. Accumulation of activated eosinophils within sinonasal tissues is a major hallmark, especially in CRS with NP (CRS-NP) [2, 3].…”

Section: Introductionmentioning

confidence: 99%

Expression and Characterization of PGD2 Receptors in Chronic Rhinosinusitis: Modulation of DP and CRTH2 by PGD2

Yamamoto¹,

Okano²,

Fujiwara³

et al. 2008

Int Arch Allergy Immunol

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“…Существует мнение, что хронический РС включает в себя группу гетерогенных заболеваний, характеризую-щихся длительным воспалением слизистой оболочки носа и ОНП [19,24]. Прежде всего, его подразделяют на хронический РС без назальных полипов и полипозный РС.…”

Section: вестник оториноларингологии 5 2016unclassified

“…Высказываются предложения о целесообразности выделения в отдельные группы формы РС, развившиеся на фоне атопии и бронхиальной астмы, грибковой, одон-тогенной инфекции и иммунодефицитных состояний (например, дефицита IgG3), а остальные относить в раз-ряд «неуточненных» [6,24].…”

Section: вестник оториноларингологии 5 2016unclassified

The use of intranasal glucocorticosteroids in the treatment of rhinosinusitis: Focus on mometasone furoate

Ушкалова

Zyryanov

Shvarts

2016

Vestn. otorinolaringol.

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“…Chronic rhinosinusitis (CRS) is one of the most prevalent inflammatory diseases defined as inflammation of nasal cavity and paranasal sinuses lasting at least 12 consecutive weeks, presenting with symptoms such as itching, sneezing, rhinorrhea, and nasal congestion [1]. Its prevalence among US adult population was estimated about 16% according to 2010 national health interview survey [2].…”

Section: Introductionmentioning

confidence: 99%

Mood Disorders among Chronic Rhino-Sinusitis Patients

Gharaati¹,

Amini²,

Abdollahi³

et al. 2017

J Psychiatry

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Adult Chronic Rhinosinusitis: Definitions, Diagnosis, Epidemiology, and Pathophysiology

Cited by 607 publications

References 146 publications

Expression and Characterization of PGD<sub>2</sub> Receptors in Chronic Rhinosinusitis: Modulation of DP and CRTH2 by PGD<sub>2</sub>

Expression and Characterization of PGD<sub>2</sub> Receptors in Chronic Rhinosinusitis: Modulation of DP and CRTH2 by PGD<sub>2</sub>

The use of intranasal glucocorticosteroids in the treatment of rhinosinusitis: Focus on mometasone furoate

Mood Disorders among Chronic Rhino-Sinusitis Patients

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