Adult Cœliac Disease in Hyposplenic Patients

Ferguson, Anne; Hutton, MargaretM.; Maxwell, J. D.; Murray, Drew

doi:10.1016/s0140-6736(70)90405-8

Cited by 66 publications

(24 citation statements)

References 8 publications

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“…The underlying idea is that hyposplenism is common in coeliac disease,10 – 12 27 and coeliac disease may even be the most common cause of non-surgical asplenia in the Western world 28. In a recent Italian study,11 the authors counted pitted red cells (erythrocytes with membrane abnormalities) as a measure of hyposplenism and found higher average pitted red cell counts in coeliac disease patients than in patients with other autoimmune disease or in healthy volunteers 11.…”

Section: Discussionmentioning

confidence: 99%

Coeliac disease and risk of sepsis

Ludvigsson

Olén

Bell

et al. 2008

Gut

114

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Section: Discussionmentioning

confidence: 99%

Coeliac disease and risk of sepsis

Ludvigsson

Olén

Bell

et al. 2008

Gut

114

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“…The association between coeliac disease and hyposplenism has been recognized since 1970. 118 Up to 30% of patients with coeliac disease are functionally hyposplenic or asplenic at diagnosis. 119 Potential aetiologies of this manifestation include haemodyamic changes, such as higher blood velocity and flow after a meal and generally lower intrasplenic resistance indexes, 120 or might be a sign of general r eticularendothelia l dysfunction, especially as the coexistence of other autoimmune disorders increases the risk of impaired spleen function.…”

Section: Livermentioning

confidence: 99%

Extraintestinal manifestations of coeliac disease

Leffler

Green

Fasano

2015

Nat Rev Gastroenterol Hepatol

232

148

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Coeliac disease is a common disorder that can arise at any age and typically presents with a broad spectrum of symptoms. The disease is thought to be underdiagnosed, in part owing to the fact that coeliac disease is often characterized by associated conditions and extraintestinal manifestations that can misdirect and impede diagnosis. Some of these manifestations are direct consequences of autoimmunity, such as dermatitis herpetiformis or gluten ataxia, whereas others are indirectly related to inflammation and/or malabsorption including anaemia, osteoporosis, short stature and delayed puberty. Any organ from the central nervous system to joints, liver or teeth can be affected. In some cases, extraintestinal symptoms are the only clinical manifestations of coeliac disease or occur in conjunction with diarrhoea and malabsorptive symptoms. An increased awareness among medical practitioners of the variety of extraintestinal manifestations of coeliac disease is essential to improve diagnosis and treatment.

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“…101,102 Unsuspected CD may be found when patients with evidence of hyposplenism are investigated for the condition. 103 Splenic hypofunction can be demonstrated using scintigraphy and measurements of the clearance of labeled heatdamaged red cells. 101 A commonly used method of assessing splenic function in patients with CD is to count "pitted" erythrocytes by interference contrast microscopy.…”

Section: Splenic Dysfunctionmentioning

confidence: 99%

Hematologic manifestations of celiac disease

Halfdanarson¹,

Litzow²,

Murray

2006

Blood

321

281

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Celiac disease is a common systemic disorder that can have multiple hematologic manifestations. Patients with celiac disease may present to hematologists for evaluation of various hematologic problems prior to receiving a diagnosis of celiac disease. Anemia secondary to malabsorption of iron, folic acid, and/or vitamin B12 is a common complication of celiac disease and many patients have anemia at the time of diagnosis. Celiac disease may also be associated with thrombocytosis, thrombocytopenia, leukopenia, venous thromboembolism, hyposplenism, and IgA deficiency. Patients with celiac disease are at increased risk of being diagnosed with lymphoma, especially of the T-cell type. The risk is highest for enteropathy-type T-cell lymphoma (ETL) and B-cell lymphoma of the gut, but extraintestinal lymphomas can also be seen. ETL is an aggressive disease with poor prognosis, but strict adherence to a gluten-free diet may prevent its occurrence.

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Adult Cœliac Disease in Hyposplenic Patients

Cited by 66 publications

References 8 publications

Coeliac disease and risk of sepsis

Coeliac disease and risk of sepsis

Extraintestinal manifestations of coeliac disease

Hematologic manifestations of celiac disease

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