Transgender medicine presents a particular challenge for the development of evidence-based guidelines, due to limitations in the available body of evidence as well as the exclusion of gender identity data from most public health surveillance activities. The guidelines that have been published are often based on expert opinion, small studies, and data gathered outside the US. The existence of guidelines, however, helps legitimate the need for gender-affirming medical and surgical interventions. Research conducted on transgender populations should be grounded in gender-affirming methodologies and focus on key areas such as health outcomes after gender-affirming interventions.
IntroductionThe past three decades have seen exponential growth in the range and depth of evidence-based guidelines in a broad range of medical disciplines [1]. The term "evidence-based medicine" first appeared in a brief article published in 1992 in the Journal of the American Medical Association (JAMA) by the Evidence-Based Medicine Working Group [2]. The article built on prior efforts to describe the development of guidelines that are accurate, accountable (to patients, science, and society), predictable (i.e., provide specific detail and figures), defensible (i.e., transparent about how they were developed and consensus was reached), and usable (in a range of real-world settings). These five key considerations in the development of evidence-based guidelines were summarized in an essay published in JAMA in 1990 [3].