Adult hippocampal ganglioneuroblastoma

Abstract

Rationale:Intracranial ganglioneuroblastoma represents a rare subtype of primitive neuroectodermal tumor. Here, we report a hippocampal ganglioneuroblastoma and a literature review of cerebral anglioneuroblastoma is carried out.Patient concerns:We report a 16-year-old male patient presenting with absence seizure and high-infiltration hippocampal ganglioneuroblastoma.Interventions:Magnetic resonance imaging (MRI) indicates a space-occupying lesion with a well-defined margin in the right temporal lobe and hippocampus. However, hyper-signal on flair and diffusion-weighted imaging (DWI) with a low apparent diffusion coefficient (ADC) value is detected, which prompts high tumoral invasiveness.Interventions:A total resection of tumor and subsequent chemotherapy combing with radiotherapy is performed.Outcomes:For a follow-up period of 60 months, no evidence of recurrence and further seizures are detected.Lessons:High-infiltration hippocampal ganglioneuroblastoma is a rare event. MRI examination often showed features of low-grade gliomas, while hyper-signal lesion on DWI with a low ADC value can be detected. Complete resection combined with fractionated radiotherapy and chemotherapy was the optimal treatment for cerebral ganglioneuroblastoma.

Primary central nervous system neuroblastomas and ganglioneuroblastomas in adult patients

“…Требуется дальнейшее изучение молекулярно-генетического профиля данных типов опухолей для поиска предиктивных маркеров. В ряде клинических наблюдений можно встретить подходы к лечению ЦНС-НБ аналогичные таковым при глиобластоме с применением темозоломида [18,[32][33][34]. Однако статус метилирования промотора гена MGMT, как основного предиктора эффективности терапии темозоломидом, в этих наблюдениях не определялся.…”

Primary Central Nervous System Neuroblastoma: An Enigmatic Entity

“…Ganglioneuroblastoma subtype is found to be associated with a good prognosis. Studies show that the ganglioneuroblastoma subtype rarely infiltrates and tends to be localised with less incidence of metastatic deposits [16,34]. This explains that patients with this subtype are likely to be offered surgery and benefit from surgical excision with overall better survival.…”