Adult hippocampal neurogenesis and related neurotrophic factors

Lee, Eugene; Son, Hyeon

doi:10.5483/bmbrep.2009.42.5.239

Cited by 202 publications

(130 citation statements)

References 76 publications

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“…The function of this regenerative capacity in adults is not completely understood, but may play a role in spatial memory formation (reviewed in Lee and Son 165 ). Neurogenesis can be stimulated by a variety of compounds in mammals, including dietary supplements such as curcumin.…”

Section: Potential Problems With Regenerating the Brainmentioning

confidence: 99%

Applied Healthspan Engineering

Larrick

Mendelsohn

2010

Rejuvenation Research

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According to the Homeric Hymn to Aphrodite, when Eos asked Zeus for Tithonus to be granted immortality, she forgot to ask for eternal youth. Applied Healthspan Engineering (AHE) seeks to address this problem. All organisms have a minimal level of functional reserve required to sustain life that eventually declines to a point incompatible with survival at death. AHE seeks to maintain or restore optimal functional reserve of critical tissues and organs. Tissue reserve correlates with well being. Diet, physical exercise, and currently available smallmolecule-based therapeutics may attenuate the rate of decline of specific organs or organ systems, but are unlikely to restore lost reserve. Inherent evolutionary-derived limitations in tissue homeostasis and cell maintenance necessitate the development of therapies to enhance regenerative processes and possibly replace whole organs or tissues. AHE supports the study of cell, tissue, and organ homeostatic mechanisms to derive new regenerative and tissue replacement therapies to extend the period of human health.

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Section: Potential Problems With Regenerating the Brainmentioning

confidence: 99%

Applied Healthspan Engineering

Larrick

Mendelsohn

2010

Rejuvenation Research

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“…Several other regulators of stem cells in the adult vertebrate brain have been implicated, such as Nitric oxide (Gibbs, 2003;Moreno-López and González-Forero, 2006), glutamate and c-aminobutryic acid (Schlett, 2006;Jagasia et al, 2006;Gakhar-Koppole, 2008;Markwardt and Overstreet-Wadiche, 2008;Mattson, 2008;Platel et al, 2010), dopamine (Cave and Baker, 2009), vascular endothelial growth factor (VEGF) (Jin et al, 2002;Sun et al, 2003;Zhu et al, 2003;Sun and Guo, 2005;Wittko et al, 2009), pigment epithelium derived growth factor (PEDF) (Ramirez-Castillejo et al, 2006), glial-cell derived neurotrophic factor (GDNF) (Chen et al, 2005;Kobayashi et al, 2006;Wei et al, 2007), brain-derived neurotrophic factor (BDNF) (Benraiss et al, 2001;Pencea et al, 2001;Scharfman et al, 2005;Rossi et al, 2006;Chan et al, 2008;Lee and Son, 2009), and epigenetic modifications by histone methylation , adding further degrees of complexity to the regulation of adult stem cells in the vertebrate brain. The roles of these regulators in zebrafish brain have not been addressed, which offers an interesting research realm.…”

Section: Regulation Of the Progenitor Cell Activitymentioning

confidence: 99%

Adult neurogenesis and brain regeneration in zebrafish

Kızıl

Kaslin

Kroehne

et al. 2012

Developmental Neurobiology

307

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Adult neurogenesis is a widespread trait of vertebrates; however, the degree of this ability and the underlying activity of the adult neural stem cells differ vastly among species. In contrast to mammals that have limited neurogenesis in their adult brains,zebrafish can constitutively produce new neurons along the whole rostrocaudal brain axis throughout its life.This feature of adult zebrafish brain relies on the presence of stem/progenitor cells that continuously proliferate,and the permissive environment of zebrafish brain for neurogenesis. Zebrafish has also an extensive regenerative capacity, which manifests itself in responding to central nervous system injuries by producing new neurons to replenish the lost ones. This ability makes zebrafish a useful model organism for understanding the stem cell activity in the brain, and the molecular programs required for central nervous system regeneration.In this review, we will discuss the current knowledge on the stem cell niches, the characteristics of the stem/progenitor cells, how they are regulated and their involvement in the regeneration response of the adult zebrafish brain. We will also emphasize the open questions that may help guide the future research.

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“…And the neurotrophin BDNF has been shown to modulate the development and function of synapses in the nervous system [23]. BDNF is important in modulating dentate gyrus neurogenesis [24] and in synaptogenesis [25].…”

Section: Synaptic Functionmentioning

confidence: 99%

Microarray Analysis of microRNAs Expression Profiles in Adult and Aged Mice Hippocampus

Jia¹,

Liu²,

Yu³

et al. 2017

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Purpose: To analyze the miRNA expression profiles in C57 mice ageing hippocampus in detail, and investigate the functional information of these hippocampus specific miRNAs and the related regulatory networks. Methods: Microarrays were used to analyze miRNA expression profiles in adult and aged hippocampi, and bioinformatics analysis methods, such as three public datasets (Mirbase, Miranda, and Mirdb), DAVID online tools and KEGG pathway tools were used to study in detail the target genes of the differentially expressed miRNAs. Results: 26 differentially expressed miRNAs were identified by greater than 1.5-fold change (intersection of two sets), of which 16 were up-regulated and 10 were down-regulated. DAVID Functional Annotation Cluster (FAC) analysis of the 132 predicted target genes of up-regulated miRNAs revealed confident enrichment scores for synaptic function and apoptosis etc. (Figure 1), indicating the functional significance and importance of these miRNAs during hippocampal ageing. Conclusions: Bioinformatic analyses of the differentially expressed miRNAs have identified a number of miRNAs with putative involvement in the hippocampus ageing process. This study lays a solid foundation for further studies to clarify the important regulation function of miRNAs in ageing process of brain tissue.

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Adult hippocampal neurogenesis and related neurotrophic factors

Cited by 202 publications

References 76 publications

Applied Healthspan Engineering

Applied Healthspan Engineering

Adult neurogenesis and brain regeneration in zebrafish

Microarray Analysis of microRNAs Expression Profiles in Adult and Aged Mice Hippocampus

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