Adult house mouse (Mus musculus) ultrasonic calls: hormonal and pheromonal regulation

Nyby, John

doi:10.1016/b978-0-12-374593-4.00029-2

Cited by 8 publications

(6 citation statements)

References 62 publications

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“…Of particular interest is that, while male house mice did not call in response to male urine, males did call indiscriminately in response to female urine from different stages of the oestrous cycle, and even to ovariectomized female urine Nyby, 2010). These results are directly comparable to what we found in our experiment.…”

Section: Discussionsupporting

confidence: 89%

“…Because female S. teguina have short cycles and enter oestrus every four days, the males' behaviour could be an adaptive response (i.e., may result in increased male reproductive success if the female does return in response to the male's singing), whether or not the encountered female is in oestrus. Nyby (2010) proposed a similar hypothesis, suggesting that, because of the short oestrous cycle in the house mouse, a communicatory bond may keep a non-receptive female around until she becomes receptive. These hypotheses remain to be tested experimentally in both species.…”

Section: Discussionmentioning

confidence: 99%

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Singing, allogrooming, and allomarking behaviour during inter- and intra-sexual encounters in the Neotropical short-tailed singing mouse (Scotinomys teguina)

Phelps

Tang‐Martínez

Fernández-Vargas

2011

Behav

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Singing, allogrooming, and allomarking behaviour during inter- and intra-sexual encounters in the Neotropical short-tailed singing mouse (Scotinomys teguina)

Phelps

Tang‐Martínez

Fernández-Vargas

2011

Behav

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“…The findings by Shah & Nyby, together with our current results, may suggest that ghrelin exerts different effects on specific aspects of the various components of sexually dimorphic reproductive behaviours. This view is supported by the recent evidence that separate, although to a large extent overlapping, neural circuits govern mating behaviours, ultrasonic vocalizations, bedding preference and aggression (Nyby ; Anderson ; Xu et al . ; Manoli et al .…”

Section: Discussionmentioning

confidence: 72%

The role of ghrelin signalling for sexual behaviour in male mice

et al. 2014

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Ghrelin, a gut-brain signal, is well known to regulate energy homeostasis, food intake and appetite foremost via hypothalamic ghrelin receptors (GHS-R1A). In addition, ghrelin activates the reward systems in the brain, namely the mesolimbic dopamine system, and regulates thereby the rewarding properties of addictive drugs as well as of palatable foods. Given that the mesolimbic dopamine system mandates the reinforcing properties of addictive drugs and natural rewards, such as sexual behaviour, we hypothesize that ghrelin plays an important role for male sexual behaviour, a subject for the present studies. Herein we show that ghrelin treatment increases, whereas pharmacological suppression (using the GHSR-1A antagonist JMV2959) or genetic deletion of the GHS-R1A in male mice decreases the sexual motivation for as well as sexual behaviour with female mice in oestrus. Pre-treatment with L-dopa (a dopamine precursor) prior to treatment with JMV2959 significantly increased the preference for female mouse compared with vehicle treatment. On the contrary, treatment with 5-hydroxythyptohan (a precursor for serotonin) prior to treatment with JMV2959 decreased the sexual motivation compared to vehicle. In separate experiments, we show that ghrelin and GHS-R1A antagonism do not affect the time spent over female bedding as measured in the androgen-dependent bedding test. Collectively, these data show that the hunger hormone ghrelin and its receptor are required for normal sexual behaviour in male mice and that the effects of the ghrelin signalling system on sexual behaviour involve dopamine neurotransmission.

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“…USV emission can also indicate the anticipation of a female mouse. When female mice are odorized with various chemicals, males learn to associate the smell of the chemicals with the presence of a female and vocalize ultrasounds just to the presentation of the chemicals (review by Nyby ). Thus, USV production does not only characterize arousal as induced by a change of the stimulus context but also implicates a positive background state (i.e.…”

Section: Discussionmentioning

confidence: 98%

Ultrasonic vocalizations of adult male Foxp2‐mutant mice: behavioral contexts of arousal and emotion

Gaub

Fisher

Ehret

2016

Genes Brain and Behavior

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Adult mouse ultrasonic vocalizations (USVs) occur in multiple behavioral and stimulus contexts associated with various levels of arousal, emotion and social interaction. Here, in three experiments of increasing stimulus intensity (water; female urine; male interacting with adult female), we tested the hypothesis that USVs of adult males express the strength of arousal and emotion via different USV parameters (18 parameters analyzed). Furthermore, we analyzed two mouse lines with heterozygous Foxp2 mutations (R552H missense, S321X nonsense), known to produce severe speech and language disorders in humans. These experiments allowed us to test whether intact Foxp2 function is necessary for developing full adult USV repertoires, and whether mutations of this gene influence instinctive vocal expressions based on arousal and emotion. The results suggest that USV calling rate characterizes the arousal level, while sound pressure and spectrotemporal call complexity (overtones/harmonics, type of frequency jumps) may provide indices of levels of positive emotion. The presence of Foxp2 mutations did not qualitatively affect the USVs; all USV types that were found in wild-type animals also occurred in heterozygous mutants. However, mice with Foxp2 mutations displayed quantitative differences in USVs as compared to wild-types, and these changes were context dependent. Compared to wild-type animals, heterozygous mutants emitted mainly longer and louder USVs at higher minimum frequencies with a higher occurrence rate of overtones/harmonics and complex frequency jump types. We discuss possible hypotheses about Foxp2 influence on emotional vocal expressions, which can be investigated in future experiments using selective knockdown of Foxp2 in specific brain circuits.

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Adult house mouse (Mus musculus) ultrasonic calls: hormonal and pheromonal regulation

Cited by 8 publications

References 62 publications

Singing, allogrooming, and allomarking behaviour during inter- and intra-sexual encounters in the Neotropical short-tailed singing mouse (Scotinomys teguina)

Singing, allogrooming, and allomarking behaviour during inter- and intra-sexual encounters in the Neotropical short-tailed singing mouse (Scotinomys teguina)

The role of ghrelin signalling for sexual behaviour in male mice

Ultrasonic vocalizations of adult male Foxp2‐mutant mice: behavioral contexts of arousal and emotion

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