Adult intradural intramedullary astrocytomas: a multicenter analysis

Khalid, Syed I.; Kelly, Ryan; Carlton, Adam; Wu, Rita; Peta, Akhil; Melville, Patrick; Maasarani, Samantha; Meyer, Haley; Adogwa, Owoicho

doi:10.21037/jss.2018.12.06

Cited by 37 publications

(37 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The neurological outcome and deterioration after surgery did not significantly correlate with the tumor entity and WHO grading, whereas the follow-up data suggested a strong correlation between the WHO grade and overall survival as well as long-term functionality, similar to current evidence [ 5 , 15 , 17 ]. In a case series of 20 patients published in 2016, the authors reported a neurological deterioration in 51.5% of the patients postoperatively [ 18 ], which is consistent with our results (neurological deterioration in 48.8%).…”

Section: Discussionsupporting

confidence: 84%

Surgical treatment and neurological outcome of infiltrating intramedullary astrocytoma WHO II–IV: a multicenter retrospective case series

et al. 2020

View full text Add to dashboard Cite

Introduction Primary malignant spinal astrocytomas present rare oncological entities with limited median survival and rapid neurological deterioration. Evidence on surgical therapy, adjuvant treatment, and neurological outcome is sparse. We aim to describe the treatment algorithm and clinical features on patients with infiltrating intramedullary astrocytomas graded WHO II–IV. Methods The following is a multicentered retrospective study of patients treated for spinal malignant glioma WHO II–IV in five high-volume neurosurgical departments from 2008 to 2019. Pilocytic astrocytomas were excluded. We assessed data on surgical technique, perioperative neurological status, adjuvant oncological therapy, and clinical outcome. Results 40 patients were included (diffuse astrocytoma WHO II n = 11, anaplastic astrocytoma WHO III n = 12, WHO IV n = 17). Only 40% were functionally independent before surgery, most patients presented with moderate disability (47.5%). Most patients underwent a biopsy (n = 18, 45%) or subtotal tumor resection (n = 15, 37.5%), and 49% of the patients deteriorated after surgery. Patients with WHO III and IV tumors were treated with combined radiochemotherapy. Median overall survival (OS) was 46.5 months in WHO II, 25.7 months in WHO III, and 7.4 months in WHO IV astrocytomas. Preoperative clinical status and WHO significantly influenced the OS, and the extent of resection did not. Conclusion Infiltrating intramedullary astrocytomas WHO II–IV present rare entities with dismal prognosis. Due to the high incidence of surgery-related neurological impairment, the aim of the surgical approach should be limited to obtaining the histological tissue via a biopsy or, tumor debulking in cases with rapidly progressive severe preoperative deficits.

show abstract

Section: Discussionsupporting

confidence: 84%

Surgical treatment and neurological outcome of infiltrating intramedullary astrocytoma WHO II–IV: a multicenter retrospective case series

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Therefore, complete removal of the tumour should be the goal of the surgery. Furthermore, it is unclear if patients with spinal astrocytoma benefit from gross total resection as patients with spinal ependymoma do [135][136][137][138]. Additionally, gross total resection is difficult to achieve in patients with spinal astrocytoma without causing a worse neurological outcome, which is why the primary goal of surgery is to spare the surrounding nervous tissue [139,140].…”

Section: Discussionmentioning

confidence: 99%

Spinal intramedullary schwannomas—report of a case and extensive review of the literature

et al. 2020

View full text Add to dashboard Cite

Intramedullary schwannomas (IMS) represent exceptional rare pathologies. They commonly present as solitary lesions; only five cases of multiple IMS have been described so far. Here, we report the sixth case of a woman with multiple IMS. Additionally, we performed the first complete systematic review of the literature for all cases reporting IMS. We performed a systematic review of the literature in PubMed, EMBASE and Cochrane Central Register of Controlled (CENTRAL) to retrieve all relevant studies and case reports on IMS. In a second step, we analysed all reported studies with respect to additional cases, which were not identified through the database search. Studies published in other languages than English were included. One hundred nineteen studies including 165 reported cases were included. In only five cases, the patients harboured more than one IMS. Gender ratio showed a ratio of nearly 3:2 (male:female); mean age of disease presentation was 40.2 years; 11 patients suffered from neurofibromatosis (NF) type 1 or 2 (6.6%). IMS are rare. Our first systematic review on this pathology revealed 166 cases, including the here reported case of multiple IMS. Our review offers a basis for further investigation on this disease.

show abstract

“…Spinadaki tümörler, merkezi sinir sistemindeki tüm tümörlerin yaklaşık %15'ini oluşturmakta ve genellikle benign olarak ortaya çıkmaktadır 3 . Tümörler dokular üzerinde baskı yaparak nörolojik sistemin işlevini bozabilir 4 . Spinal tümörlerinin semptomları arasında ağrı, nöbet, bulantı ve kusma, görme ve işitme bozukluğu, uyuşukluk ve felç yer almaktadır 5 .…”

Section: Introductionunclassified

Köyde Yaşayan Spinal Tümör Tanılı Erkek Hastanın Gündoğumu Modeli ile Kültürel Değerlendirilmesi

Kılınç

Aslan

2021

Hacettepe Üniversitesi Hemşirelik Fakültesi Dergisi

View full text Add to dashboard Cite

Leininger'in Kültürel Bakım Teorisindeki amacı insan kültürlerinde hemşirelik bakımındaki girişimlerin farklılıklarını ve kültürün bireylerin sağlık durumlarına etkilerini açıklamaktır. Literatür kültürel yeterliliğin, sağlık bakım kalitesinin önemli bileşenlerinden biri ve sağlık bakım çıktıları üzerinde iyileştirici etkisi olduğunu belirtmektedir. Bu olgu sunumunun amacı köyde yaşayan bir hastayı Gündoğumu Modeli ile değerlendirmek ve kültürel açıdan yeterli hemşirelik bakımının sonuçlarına dikkat çekmektir. Hastanın kültürel bakım özelliklerine yönelik bulguları 10 başlık altında ele alınmıştır. Süreç boyunca araştırmacı hasta, hasta yakını, hemşireler ve hekimler ile birlikte iş birliği yapmıştır. Uygun iletişim dilini kullanarak hastanın kültürel değerlendirmesini tamamlamıştır. Hastayı kültürel yönden değerlendirdikten sonra ise uygun kültürel bakım kararı almıştır. Hastanın kültürel değerlendirilmesinde bazı geleneksel uygulamaların (zeytinyağlı incir tüketimi, bitki çayı kullanımı) olduğu tespit edilmiştir. Hasta için olumsuz etkisi olmayan bu uygulamalar için hemşire tarafından "kültürel bakımı koruma/sürdürme kararı" alınmıştır. Sonuç olarak, hastaya bütüncül ve kültürel yeterli hemşirelik bakımı verilmiştir.

show abstract

Adult intradural intramedullary astrocytomas: a multicenter analysis

Cited by 37 publications

References 28 publications

Surgical treatment and neurological outcome of infiltrating intramedullary astrocytoma WHO II–IV: a multicenter retrospective case series

Surgical treatment and neurological outcome of infiltrating intramedullary astrocytoma WHO II–IV: a multicenter retrospective case series

Spinal intramedullary schwannomas—report of a case and extensive review of the literature

Köyde Yaşayan Spinal Tümör Tanılı Erkek Hastanın Gündoğumu Modeli ile Kültürel Değerlendirilmesi

Contact Info

Product

Resources

About