Adult Kawasaki disease: Evaluating the fluctuation of circulating lymphocytes associated with i.v. immunoglobulin treatment

Fujimoto, Noriki; Teramura, Kazuya; Tanaka, Toshihiro

doi:10.1111/j.1346-8138.2012.01522.x

Cited by 3 publications

(12 citation statements)

References 5 publications

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“…In addition to the mouse autoimmune disease model, such as experimental autoimmune encephalomyelitis, B10 cells have been reported to be associated with human autoimmune diseases like systemic lupus erythematosus and rheumatoid arthritis . We reported previously that the increase of B10 cells was not observed after IVIG treatment in a case of adult Kawasaki disease . As for autoimmune blistering diseases, it was reported recently that the frequency of CD24 high CD38 high regulatory B cells was elevated in patients with pemphigus .…”

Section: Discussionmentioning

confidence: 93%

“…5,8,9 We reported previously that the increase of B10 cells was not observed after IVIG treatment in a case of adult Kawasaki disease. 3 As for autoimmune blistering diseases, it was reported recently that the frequency of CD24 high CD38 high regulatory B cells was elevated in patients with pemphigus. 10 However, there has been only one report that evaluated the association of B10 cells and the response to the treatment of pemphigus, which speculated that long-term remission after rituximab treatment was related to the increase of B10 cells.…”

Section: Discussionmentioning

confidence: 99%

“…The populations of IL‐10‐secreting B cells were evaluated by intracellular cytokine staining of peripheral blood mononuclear cells (PBMC) using flow cytometry. PBMC were prepared by Ficoll‐Paque Plus (GE Healthcare, Pittsburgh, PA, USA) and were stimulated for 20 h in vitro with 50 ng/mL phorbol 12‐myristate‐13‐acetate (PMA; Sigma‐Aldrich, St Louis, MO, USA), 1 μg/mL ionomycin (Sigma‐Aldrich), lipopolysaccharide (LPS) 10 μg/mL (Sigma‐Aldrich) and Brefeldin A (Biolegend, San Diego, CA, USA) . Cultured cells were stained for cell surface markers with fluorescein isothiocyanate‐conjugated anti‐CD19 (BioLegend), phycoerythrin (PE)‐conjugated anti‐CD5 (BioLegend), PE‐conjugated anti‐CD9 (BioLegend) and PE‐conjugated anti‐CD27 antibodies (BioLegend), fixed with 4% paraformaldehyde, permeabilized with permeabilization buffer (eBioscience, San Diego, CA, USA), and stained with allophycocyanin‐conjugated anti‐IL‐10 antibodies (BD Biosciences, San Jose, CA, USA).…”

Section: Case Reportmentioning

confidence: 99%

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Increase of interleukin‐10‐producing B cells associated with long‐term remission after i.v. immunoglobulin treatment for pemphigus

Kabuto

Fujimoto

Tanaka

2016

The Journal of Dermatology

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We present a refractory case of pemphigus vulgaris that achieved long-term remission after i.v. immunoglobulin treatment (IVIG). We evaluated the fluctuation of circulating interleukin-10-producing B cells (B10 cells) during the course in our case and other three patients with pemphigus treated with IVIG without clinical remission. B10 cells were observed predominantly in CD1d-and CD27 + populations among CD19 + cells in healthy controls, as well as in patients with pemphigus. The frequency of B10 cells among CD19 + cells increased in our case, but not in the other three patients without clinical remission, which leads to speculation on the association between the increase of B10 cells and the achievement of long-term remission after IVIG treatment.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

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Increase of interleukin‐10‐producing B cells associated with long‐term remission after i.v. immunoglobulin treatment for pemphigus

Kabuto

Fujimoto

Tanaka

2016

The Journal of Dermatology

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“…According to a review in 2011, 91 cases of adult KD had been described until that time [ 5 ]. Eight more cases have been added to the medical literature since then [ 6 - 13 ]. To the best of our knowledge, our case is the 100th one.…”

Section: Introductionmentioning

confidence: 99%

“…Clinical and laboratory findings concerning liver inflammation are jaundice [ 32 , 40 , 48 , 49 ], hepatomegaly [ 15 , 32 , 50 ], right upper quadrant pain [ 32 , 39 ], cholestatic hepatitis [ 6 , 44 , 46 - 49 , 51 ], hepatic artery aneurysm [ 32 ], elevated aspartate and alanine aminotransferase levels [ 2 , 8 , 11 , 13 , 33 , 34 , 40 , 41 , 43 , 52 , 53 ] and low albumin levels [ 11 , 40 , 53 ].…”

Section: Introductionmentioning

confidence: 99%

Adult Kawasaki disease in a European patient: a case report and review of the literature

et al. 2015

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IntroductionKawasaki disease is an acute necrotising vasculitis of the medium- and small-sized vessels, occurring mainly in Japanese and Korean babies and children, aged 6 months to 5 years. Its main complication is damage of coronary arteries, which has the potential to be fatal. Here we report a rare case of Kawasaki disease that occurred in a 20-year-old Greek adult.Case presentationA 20-year-old Greek man presented with high fever, appetite loss, nausea and vomiting, headache and significant malaise. He had an erythema of the palms and strikingly red lips and conjunctiva. As he did not respond to broad-spectrum antibiotics and after having excluded other possible diagnoses, the diagnosis of Kawasaki disease was set. He was treated with intravenous immunoglobulin and oral aspirin on the 10th day since the onset of the illness. His clinico-laboratory response was excellent and no coronary artery aneurysms were detected in coronary artery computed tomography performed 1 month later.ConclusionsThis report of an adult case of European Kawasaki disease may be of benefit to physicians of various specialties, including primary care doctors, hospital internists, intensivists and cardiologists. It demonstrates that a case of prolonged fever, unresponsive to antibiotics, in the absence of other diagnoses may be an incident of Kawasaki disease. It is worth stressing that such a diagnosis should be considered, even if the patient is adult and not of Asian lineage.

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Two Cases of Adult-onset Kawasaki Disease with a Difficult Diagnosis

et al. 2023

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We encountered two consecutive cases of adult-onset Kawasaki disease (AKD) that were difficult to diagnose. In both cases, Kawasaki disease was not considered as a differential diagnosis in the early stages. However, it was possible to make a diagnosis by citing the disease as a differential diagnosis and introducing the patients to the pediatrics department. AKD has a minimal incidence rate and may have a clinical course different from that of childhood-onset Kawasaki disease. Therefore, it is necessary to incorporate Kawasaki disease into the differentiation of an adult fever and to consult with a pediatrician for its diagnosis.

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Adult Kawasaki disease: Evaluating the fluctuation of circulating lymphocytes associated with i.v. immunoglobulin treatment

Cited by 3 publications

References 5 publications

Increase of interleukin‐10‐producing B cells associated with long‐term remission after i.v. immunoglobulin treatment for pemphigus

Increase of interleukin‐10‐producing B cells associated with long‐term remission after i.v. immunoglobulin treatment for pemphigus

Adult Kawasaki disease in a European patient: a case report and review of the literature

Two Cases of Adult-onset Kawasaki Disease with a Difficult Diagnosis

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