Adult Kawasaki syndrome associated with HIV infection and anticardiolipin antibodies

Elevated IgA and IgM Anticardiolipin Antibodies in Acute Kawasaki Disease

“…A case report of an adult with human immunodeficiency virus who developed Kawasaki disease also describes elevated aCL of the IgG subclass [13]. A previous study of 36 Kawasaki disease patients (all of whom had received aspirin and 20 patients had been treated with immunoglobulin) found an aCL response in all three immunoglobulin subclasses, with a peak at 2 weeks and a decline in the levels after 2 months in all but 5 (8%).…”

Kawasaki-like syndromes in HIV-infected adults

“…Of these, KLS led to diagnosis of HIV infection in 2 cases. 6,12 For the 18 patients with known HIV infection, mean duration of the disease was 8.8 years when KLS was detected. The mode of HIV contamination is not described in most of the cases.…”

Vasculitic Syndromes in HIV-Infected Patients

“…This feature may also be observed in HIV-infected patients with Kawasaki-like syndrome [51][52][53][54][55][56][57][58]. These plasma cells are oligoclonal based on related CDR3 DNA sequences and on that basis have been postulated to be responding to local antigen (likely an infectious agent) within the coronary artery wall [62,63].…”

“…Kawasaki-like syndrome appears to have an association with HIV infection based on the 11 adult cases reported in the literature [51][52][53][54][55][56][57][58]. Kawasaki disease is a vasculitic syndrome characterized by fever Ͼ5 days, bilateral conjunctivitis, changes of the oropharynx including erythema or edema of the hands and feet, rash and cervical lymphadenopathy.…”