Adult linear IgA bullous dermatosis with bronchial involvement

Verhelst, F.; Demedts, Maurice; Verschakelen, Johny; Verbeken, Eric; Mariën, K.; Peeters, Chris

doi:10.1111/j.1365-2133.1987.tb05884.x

Cited by 20 publications

(6 citation statements)

References 4 publications

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“…LABD or LAGBD rarely involves the lower respiratory tract. The few case reports of respiratory lesions associated with these skin conditions have described involvement of the bronchial mucosa with subepithelial blister formation [7], sarcoidosis [8] and tracheomalacia [5,9]. However, in this case, bronchoscopy revealed no abnormalities from the pharynx to the subsegmental bronchi.…”

Section: Discussionmentioning

confidence: 42%

Interstitial Pneumonia Associated with Linear Immunoglobulin A/Immunoglobulin G Bullous Dermatosis

Kakugawa¹,

et al. 2013

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A 76-year-old man with interstitial lung disease was admitted to our institution after developing persistent dyspnea upon effort. He also had a relapse of bullous eruptions on the skin of the trunk and extremities, previously diagnosed as vesicular pemphigoid. Direct immunofluorescence of a skin biopsy specimen using fluorescence microscopy showed the linear deposition of immunglobulin A (IgA), IgG and C3 along the basement membrane. These findings indicated a definitive diagnosis of linear IgA/IgG bullous dermatosis. Chest computed tomography, bronchoalveolar lavage and transbronchial lung biopsy findings suggested nonspecific interstitial pneumonia. Direct immunofluorescence of the lung biopsy specimens using fluorescence microscopy also showed a deposition of IgA, IgG and C3 along the epithelial cell membranes and basement membranes of the bronchioles and alveoli. Lung disorders associated with linear IgA/IgG bullous dermatosis are extremely rare and, to our knowledge, this is the first report of such a case of interstitial pneumonia.

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Section: Discussionmentioning

confidence: 42%

Interstitial Pneumonia Associated with Linear Immunoglobulin A/Immunoglobulin G Bullous Dermatosis

Kakugawa¹,

et al. 2013

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“…The relationship between LAD and mucous membrane pemphigoid has been questioned (10), and an IgA dermatosis proposed (11). Oral manifestations may be atypical (12) and there are reports of other mucosal sites being involved, such as bronchus (13), vulva (14) and conjuctiva (7).…”

Section: Discussionmentioning

confidence: 99%

Linear IgA disease (LAD): immunoglobulin deposition in oral and colonic lesions

Cowan

Pj²,

Walsh

et al. 1995

J Oral Pathology Medicine

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Two cases of adult linear IgA disease (LAD) with oral and colonic involvement are presented. Oral findings, for both patients, were of widespread painful ulceration present for two to three months and diagnosis was confirmed by biopsy and direct immunofluorescence. Colonic symptoms preceded oral symptoms in both cases and a number of investigations were undertaken, including routine histological examination, which suggested either lymphocytic colitis or Crohn's disease. Immunofluorescence studies showed linear IgA deposition confined to the distal colon. These cases highlight that large bowel involvement can be a feature of linear IgA disease and for the first time demonstrate IgA deposition at that site.

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“…6 When treating this disease, the administration of DDS (4-4-diamino-diphenyl sulfone) and corticosteroids is considered effective. 5,6 Oral mucosal lesions are occasionally involved in patients with linear IgA bullous dermatosis, [7][8][9] and patients with oral and nasal mucosal lesions have been reported. 7 A clinical study showed oral mucosal involvement in 16 out of 101 patients (15.8 per cent) with this disease.…”

Section: Casementioning

confidence: 99%

Initial presentation and fatal complications of linear IgA bullous dermatosis in the larynx and pharynx

et al. 2005

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Two cases of linear IgA bullous dermatosis initially presenting as ulcerative lesions in the larynx and pharynx are reported. It was difficult to diagnose and treat the lesions, but they were finally diagnosed from the histopathological findings of accompanying skin lesion specimens. One of the patients required a tracheostomy due to increased airway stenosis by a laryngeal lesion. Despite general corticosteroid administration this could not be completely resolved, although partial opening of the glottis was observed, and the patient died of accidental tracheostomy tube complications during home care. Although there are no reports of this disease in the otolaryngological field, these rare diseases involving the skin and entire body should be considered in the differential diagnosis of laryngeal and pharyngeal ulcerative lesions, including airway stenosis. Furthermore, simple and safe procedures for relieving airway stenosis should be selected for rare and difficult-to-diagnose airway disease, prior to the final diagnosis.

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Adult linear IgA bullous dermatosis with bronchial involvement

Cited by 20 publications

References 4 publications

Interstitial Pneumonia Associated with Linear Immunoglobulin A/Immunoglobulin G Bullous Dermatosis

Interstitial Pneumonia Associated with Linear Immunoglobulin A/Immunoglobulin G Bullous Dermatosis

Linear IgA disease (LAD): immunoglobulin deposition in oral and colonic lesions

Initial presentation and fatal complications of linear IgA bullous dermatosis in the larynx and pharynx

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