Adult linear immunoglobulin A disease manifesting as desquamative gingivitis

Porter, Stephen; Scully, Crispian; Midda, M; Eveson, J.W.

doi:10.1016/0030-4220(90)90208-a

Cited by 37 publications

(17 citation statements)

References 35 publications

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“…Treatments include topical or systemic steroids, dapsone or sulphapyridine. 12,59 Chronic ulcerative stomatitis This is a new entity characterized by unique immunostaining properties. 60 It mimics oral lichen planus both clinically and histologically.…”

Section: Pemphigusmentioning

confidence: 99%

“…[3][4][5][6] Other causes include allergic reactions to toothpastes/mouth rinses (plasma cell gingivitis), [7][8][9] Crohn's disease, 10 psoriasis, 11 linear IgA disease 12 and chronic ulcerative stomatitis. 13 Desquamative gingivitis can be mistaken for plaque induced gingivitis and this can lead to delayed diagnosis and inappropriate treatment of serious dermatological diseases such as pemphigoid or pemphigus.…”

mentioning

confidence: 99%

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Desquamative gingivitis: A sign of mucocutaneous disorders‐a review

Robinson

Wray

2003

Australian Dental Journal

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Desquamative gingivitis is a clinical term to describe red, painful, glazed and friable gingivae which may be a manifestation of some mucocutaneous conditions such as lichen planus or the vesiculobullous disorders. It is important to be aware of this rare clinical entity so as to distinguish desquamative gingivitis from plaque induced gingivitis which is an extremely common condition, easily recognized and treated daily by the dental practitioner. This article gives an overview of desquamative gingivitis, its presentation, the possible causes, diagnosis and treatment. Early recognition of these lesions may prevent delayed diagnosis and inappropriate treatment of potentially serious dermatological diseases.

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Section: Pemphigusmentioning

confidence: 99%

mentioning

confidence: 99%

Desquamative gingivitis: A sign of mucocutaneous disorders‐a review

Robinson

Wray

2003

Australian Dental Journal

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“…2,3 The majority of cases of CDG are now known to be due to mucocutaneous conditions, in particular lichen planus, pemphigoid and pemphigus. [4][5][6][7] Other causes include allergic reactions to toothpastes/mouth rinses (plasma cell gingivitis) [8][9][10] , Crohn's disease 11 , psoriasis 12 , linear IgA disease 13 , and chronic ulcerative stomatitis. 14 …”

Section: Introductionmentioning

confidence: 99%

Chronic desquamative gingivitis and oral health-related quality of life

Saitô

Makiishi²

2009

J Dermatol Case Rep

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Background: Chronic desquamative gingivitis is a clinical description of the gingiva which is often a presenting manifestation of dermatoses or mucocutaneous disorders. The patients often experience oral discomfort and pain, which can significantly compromise their life qualities.Main observations: Here we present a case of chronic desquamative gingivitis in a 77-year-old woman with periodontitis. After establishment of oral hygiene, initial periodontal therapy including topical steroid application was performed. Subsequent periodontal surgery resulted in further reduction of local inflammation. These interventions lead to a significant improvement in gingival lesions as well as oral health-related quality of life.Conclusions: Chronic desquamative gingivitis is often a presenting manifestation of dermatoses or mucocutaneous disorders. Correct and early diagnosis is important. Management of inflammatory conditions including periodontitis can contribute to the clinical resolution of chronic desquamative gingivitis and improve life quality of the patient. A greater awareness of this condition among dentists and dermatologists would be helpful in providing patient-centered care.

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“…However, it is generally accepted that diseases such as lichen planus and pemphigoid lesions sometimes show similiar clinical appearance (8,9). In the literature, there have also been reports of several other disorders manifesting DG including psoriasis, dermatitis herpetiformis, chronic ulcerative stomatitis, erythema multiforme, epidermolysis bullosa and Kindler Syndrome (10)(11)(12). Similar appearances may be seen in reaction to dental materials, mouth washes and medications, and in lupus erythematosis, Crohn's disease, sarcoidosis and leukemias (13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Pemphigus vulgaris and complications of systemic corticosteroid therapy: a case report

Sakallıoğlu

Açıkgöz

Keleş

et al. 2003

Journal of Oral Science

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Abstract:Pemphigus refers to a group of diseases characterized by painful lesions caused by intraepidermal acantholytic structures in the skin and mucous membrane. The exact nature of the disease remains unknown. Pemphigus is a rare chronic mucocutaneous disease characterized by intra-epithelial bulla formation, due to autoantibodies directed against proteins of the desmosome-tonofilament complex between keratinocytes. The bullous lesions are painful, slow to heal and with a tendency to become invasive. Any part of the oral cavity may be affected, with the soft palate, buccal mucosa and lips being the most common sites. The high doses and prolonged administration of corticosteroids often required to control the disease result in several side effects, many of which are serious or life-threatening. In the present case, steroid treatment was begun at 180 mg/day and subsequently increased to 250 mg/day and 350mg/day Oral lesions were treated locally with 0.2 % chlorhexidine gluconate in addition to systemic corticosteroids containing an immunosuppressive. Oral lesions were observed to recur without healing completely. Respiratory problems occured, necessitating direct lung radiographs and computerised tomography. Pulmonary embolism was diagnosed and the patient was transferred to the vascular surgery department. Unfortunately the patient died due to pulmonary embolism on the seventh day. Pemphigus vulgaris (PV) is a chronic autoimmune mucocutaneous disease that often primarily involves the oral cavity. Therefore, early diagnosis of oral symptoms is crucial for the successful treatment of PV. Although there is no consensus regarding the initial steroid dosage needed to induce remission, it is suggested that high doses of corticosteriods may cause fatal complications. (J. Oral Sci. 45, 165-169, 2003)

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Adult linear immunoglobulin A disease manifesting as desquamative gingivitis

Cited by 37 publications

References 35 publications

Desquamative gingivitis: A sign of mucocutaneous disorders‐a review

Desquamative gingivitis: A sign of mucocutaneous disorders‐a review

Chronic desquamative gingivitis and oral health-related quality of life

Pemphigus vulgaris and complications of systemic corticosteroid therapy: a case report

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