Adult neurogenesis in the hippocampus

Neurogenesis and pesticides: news of no new neurons

“…16 17 18 19 20 21 Among the neurogenic zones of the adult brain, the hippocampal formation has been extensively studied because it is involved in higher cognitive functions, mainly in memory processes and in certain affective behaviors. 22 Therefore, one of the main populations of hippocampal neurons, the granule cells of the dentate gyrus, carry the property of postnatal neurogenesis. 10 20 The majority of granule cells in the dentate gyrus are formed in the postnatal period; however, complete development of the granule cell layer occurs between approximately days 20 and 25 of life.…”

“…10 20 The majority of granule cells in the dentate gyrus are formed in the postnatal period; however, complete development of the granule cell layer occurs between approximately days 20 and 25 of life. 20 21 22 Granule cells originate from precursor cells located in the hilus of the dentate gyrus. Initially, they spread throughout the hilus and by the second postnatal week they are located in the subgranule zone of the dentate gyrus and remain mitotically active (the production of new cells was estimated at 1 neuron/2,000 existing granule cells, that is, in a mouse of 3 months, hundreds of cells are produced per day).…”

“…Initially, they spread throughout the hilus and by the second postnatal week they are located in the subgranule zone of the dentate gyrus and remain mitotically active (the production of new cells was estimated at 1 neuron/2,000 existing granule cells, that is, in a mouse of 3 months, hundreds of cells are produced per day). 20 21 22 In the vast majority of organisms, including humans, this process can continue for long periods of time, probably until senescence. 23…”

Curcumin Improves Neurogenesis in Alzheimer’s Disease Mice via the Upregulation of Wnt/β-Catenin and BDNF

“…In the DG of the adult hippocampus, stem cells can produce new neurons continuously. In this way, the DG is also called a "neurogenic niche", and continuous regeneration is termed "adult hippocampal neurogenesis" (AHN) [4]. Importantly, studies have also found that AHN is impaired in the process of aging and neurodegenerative disorders; for example, in clinical or animal AD studies, deficits in AHN have been observed [5], which can induce impairments in cognition.…”