Adult‐Onset Alcohol Suppressible Cervical Dystonia: A Case Report

Gait Impairment in Myoclonus–Dystonia (DYT-SGCE)

“… 6 Myoclonus, not dystonia, responds dramatically to alcohol. 8 , 9 The disease courses in SGCE -mutated patients might be benign and not interfere with a normal active life, 10 but there are many exceptions even within the same family. 9 , 11 …”

Gait Impairment in Myoclonus–Dystonia (DYT-<i>SGCE</i>)

“…6 Myoclonus, not dystonia, responds dramatically to alcohol. 8,9 The disease courses in SGCE -mutated patients might be benign and not interfere with a normal active life, 10 but there are many exceptions even within the same family. 9,11…”

“…8,9 The disease courses in SGCEmutated patients might be benign and not interfere with a normal active life, 10 but there are many exceptions even within the same family. 9,11 In most reported families, the worsening of myoclonus is the indicator of disease progression, 6 whereas dystonia usually remains stable during patient's life. 1 There are few reports indicating sexual differences in MDS.…”

Synaptic effects of ethanol on striatal circuitry: therapeutic implications for dystonia

“…Cases of alcohol‐responsive focal dystonia are reported more frequently than generalized dystonias. These include the following: five patients with spasmodic torticollis who benefitted from intravenous infusion of an EtOH solution [ 105 ]; spasmodic dysphonia in DYT4 dystonia [ 106 ]; a case of primary writer’s cramp that was unexpectedly improved by drinking a small amount of alcohol [ 107 ]; a 66‐year‐old woman with jerky cervical dystonia caused by a mutation in the GCH1 gene (the cause of dopa‐responsive dystonia) and with striking alcohol sensitivity [ 108 ]. Moreover, a survey in a large population of patients with laryngeal dystonia confirmed what was already observed in case reports, that is a marked improvement of voice symptoms after alcohol ingestion; this responsiveness was not attributed to the presence of voice tremor [ 109 ].…”