Adult onset centronuclear myopathy with peripheral nerve involvement

Abstract

A case of centronuclear myopathy is presented, showing a rapid course in a 47-year-old male. Clinical and muscular findings were consistent with the diagnosis of centronuclear myopathy. On nerve biopsy, there was evidence of a regenerative process. Electron microscopy showed proliferation of Schwann cells with numerous Büngner's bands and other anomalies. This rare case with peripheral nerve changes may provide evidence to support the hypothesis of peripheral nerve involvement in centronuclear myopathy.

Novel disulfide-containing diols: synthesis and application in self-healing fluorescent polyurethane elastomers

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Dynamin‐2 in nervous system disorders

“…Although CNM is intrinsically a muscle disorder, some clinical reports have shown that the peripheral nervous system is also affected in the disease (Mouren et al . ). In 2007, Echaniz‐Laguna and co‐workers observed a deficient peripheral nerve conduction in CNM‐patients harboring the dynamin‐2 middle‐domain mutation E368Q (Echaniz‐Laguna et al .…”