Adult onset Langerhans cell histiocytosis: Report of two patients

Reddy, Indukooru Subrayalu; Gowrishankar, Swarnalata; Somani, V K; Murthy, Dronamraju Buchi Narayana

doi:10.4103/0378-6323.144206

Cited by 2 publications

(8 citation statements)

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“…LCH is a considerably rare disease, especially in adults. [ 1 2 3 5 12 ] The incidence of LCH is about 1–2 cases per million in this age group. [ 1 12 ]…”

Section: Discussionmentioning

confidence: 99%

“…Oral manifestations include gingival bleeding and necrotic and ulcerative lesions over the gums. [ 3 ]…”

Section: Discussionmentioning

confidence: 99%

“…Langerhans cell histiocytosis (LCH) is a common name for a group of rare diseases, characterized by idiopathic monoclonal infiltration of Langerhans cells in different organs. [ 1 2 3 4 5 ] Whether LCH is a neoplasm or an inflammatory condition still remains controversial. [ 1 2 4 ] These cells may infiltrate at any organ such as the skin, bones, lungs, and brain.…”

Section: Introductionmentioning

confidence: 99%

“…LCH is mainly seen in children between 1 and 4 years but it can occur at any age. [ 1 3 5 ] LCH is very rare in adults and the estimated incidence of LCH is about 1–2 cases per million in adults which is lower than children. [ 1 2 3 5 9 ]…”

Section: Introductionmentioning

confidence: 99%

“…Skin lesions are common in LCH and affect about 40% of cases. [ 1 2 3 ] It is reported that skin lesions are usually the first manifestation of LCH in 80% of patients. [ 1 3 ]…”

Section: Introductionmentioning

confidence: 99%

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Langerhans Cell Histiocytosis: A Case Report with Unusual Cutaneous Manifestation

et al. 2018

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Langerhans cell histiocytosis (LCH) is characterized by idiopathic monoclonal infiltration of Langerhans cells in different organs such as the skeleton, skin, pituitary gland, liver, spleen, lungs, and the hematopoietic system. Skin lesions are common in LCH and affect about 40% of cases. It is reported that skin lesions are usually the first manifestation of LCH in 80% of patients. Usually, cutaneous presentations of LCH in adults are generalized or seborrhea-like lesions and it is often the first manifestation of disease. Here, we describe a 45-year old female who was known case of hypothyroidism, systemic lupus erythematosus, and diabetes insipidus. In our patient, cutaneous involvement was unusual. It was single and presented in unusual site (ankle) and before developing such lesion, she had diabetes insipidus for several years due to the involvement of pituitary gland.

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“…LCH is a considerably rare disease, especially in adults. [ 1 2 3 5 12 ] The incidence of LCH is about 1–2 cases per million in this age group. [ 1 12 ]…”

Section: Discussionmentioning

confidence: 99%

“…Oral manifestations include gingival bleeding and necrotic and ulcerative lesions over the gums. [ 3 ]…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Skin lesions are common in LCH and affect about 40% of cases. [ 1 2 3 ] It is reported that skin lesions are usually the first manifestation of LCH in 80% of patients. [ 1 3 ]…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations