Adult Onset Still's Disease as a Cause of Acute Severe Mitral and Aortic Regurgitation

Lee, Jae Seung; No, Il; Kang, Deok Hyun; Joo, Sun Hyung; Yoo, Bin; Moon, Hee Bom; Lee, Chang‐Keun

doi:10.3904/kjim.2005.20.3.264

Cited by 8 publications

(6 citation statements)

References 10 publications

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“…Acute aortic and mitral valvular regurgitations have been reported to be associated with adult onset Still's disease. 1 Acute AR has also been reported in ankylosing spondylitis. 2,3 Blunt chest trauma has been documented to cause laceration or rupture of an aortic cusp resulting in acute regurgitation and secondary decompensation.…”

Section: Acute Native Aortic Regurgitationmentioning

confidence: 95%

Native and Prosthetic Valve Emergencies

McClung

2016

Cardiology in Review

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Native valvular emergencies are nearly always regurgitant in nature, whereas acute prosthetic valve dysfunction can be either regurgitant or stenotic. Regardless of the etiology, the presentation of acute valvular pathology differs significantly from chronic disease in both clinical presentation and in its appearance on diagnostic modalities, and appropriate recognition is critical to the choice of the appropriate therapeutic modality. Intrinsic to the recognition of a valvular emergency is a knowledge of those conditions for which a high index of suspicion must be maintained. This article addresses the etiologies, presentation, and diagnosis of these conditions and presents the relevant data that bears on which therapy may be most appropriate for which condition.

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Section: Acute Native Aortic Regurgitationmentioning

confidence: 95%

Native and Prosthetic Valve Emergencies

McClung

2016

Cardiology in Review

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“…We looked through related articles published before June 2017 from PubMed (MEDLINE) and Web of Science, with no restriction on study design or language. Only 7 cases of AOSD-caused endocarditis were reported 3,4,5,6,7,8,9 , among which left-sided valves (including aortic and bicuspid valves) were commonly involved. Even so, it was challenging to confirm the existence of noninfective endocarditis in AOSD, especially the involvement of right-sided valves (mainly the tricuspid valve).…”

Section: Endocarditis In Adult-onset Still Disease: a Case Report Andmentioning

confidence: 99%

“…In the literature, most patients had good responses to corticosteroids, and severe heart failure seldom happened, except in 1 female patient who had to undergo valve replacement 9 . Histological analysis of valve tissues revealed chronic active inflammation with neutrophilic infiltration.…”

Section: Endocarditis In Adult-onset Still Disease: a Case Report Andmentioning

confidence: 99%

Endocarditis in Adult-onset Still Disease: A Case Report and Literature Review

2018

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“…Pericarditis and myocarditis are the most common cardiac manifestation of AOSD, but valvular involvement is also reported. 3 , 4 Here, we report a case of a young male who was initially diagnosed and treated as infective endocarditis, but later multisystemic involvement, lack of response to antibiotics, and further workup led to the diagnosis of AOSD.…”

Section: Introductionmentioning

confidence: 96%

A case report of Adult-onset Still’s disease as a cause of severe mitral regurgitation

Shah

Khan

et al. 2020

European Heart Journal - Case Reports

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Background Adult-onset Still’s disease (AOSD) is an uncommon systemic inflammatory disease, causing spiking fever, skin rash, and arthritis. Pericarditis and myocarditis are the most common cardiac manifestation of AOSD but valvular involvement is rarely reported. Case summary An 18-year-old boy presented with gradually worsening shortness of breath for 6 months. There was a history of low-grade intermittent fever and polyarthralgia affecting ankles, knees, and elbows. He was in heart failure with cardiogenic and septic shock. He was managed initially with antibiotics, inotropes, and diuretics. Echocardiography showed flail anterior mitral leaflet with severe mitral regurgitation. He remained febrile with persistent negative blood cultures. Intravenous antibiotics led to neutropenia without any response to fever and clinical status. On further workup, he was diagnosed to have AOSD, and he responded dramatically to oral steroid therapy. Later his mitral valve was replaced surgically. On follow-up, he was stable with mild exertional dyspnoea. His international normalized ratio was in therapeutic range and his follow-up echocardiography showed normally functioning mitral prosthesis. He is following rheumatology and currently on the maintenance dose of steroids. Discussion Adult-onset Still’s disease is a systemic illness with diagnosis is based on clinical features and exclusion of other illnesses. Adult-onset Still’s disease should be considered as a differential diagnosis in culture-negative endocarditis, especially in those with systemic features and non-responders to antibiotics.

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Adult Onset Still's Disease as a Cause of Acute Severe Mitral and Aortic Regurgitation

Cited by 8 publications

References 10 publications

Native and Prosthetic Valve Emergencies

Native and Prosthetic Valve Emergencies

Endocarditis in Adult-onset Still Disease: A Case Report and Literature Review

A case report of Adult-onset Still’s disease as a cause of severe mitral regurgitation

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