Adult-onset Still's Disease during Pregnancy Treated with Tocilizumab

Abstract

A 28-year-old woman exhibited a spiking fever, arthritis, and liver disfunction when she was 22 weeks pregnant. She was diagnosed with adult-onset Still's disease (AOSD). As her condition was resistant to corticosteroid therapy, tocilizumab (TCZ) was selected. The TCZ treatment was effective, and she delivered a healthy child while receiving TCZ treatment. Cases in which AOSD first arises during pregnancy are rare, and there have been no reports of TCZ treatment for AOSD being initiated during pregnancy. Although the safety of TCZ treatment during pregnancy has not been established, it may be effective against severe AOSD that develops during pregnancy.

Successful Pregnancy Outcome in a Patient with Juvenile Idiopathic Arthritis in Adulthood, Amyloid A Amyloidosis, and Chronic Kidney Disease Using Tocilizumab with Strict Blood Pressure Control

“…Notably, there have been several reports of continuing TCZ therapy during pregnancy. A summary of reported cases of continued TCZ use during pregnancy is presented in Table 1 (7)(8)(9)(10)(11)(12)(13). There are still a few case reports of continued use during pregnancy, and the recommendations according to the respective guidelines are summarized in Table 2 (2, 14-16).…”

Targeted treatment challenges in patients with adult-onset Still’s disease

“…Применение БПВП во время беремен-ности ограничено тератогенным и эмбриотоксическим эффектами большинства представителей данной группы препаратов. Безопасность терапии ГИБП у беременных изучена недостаточно, хотя описаны несколько случаев успешного применения блокаторов цитокинов, в частности анакинры, для контроля активности заболевания и минимизации использования глюкокортикостероидов [23][24][25].…”