Adult-onset Still’s disease

Bagnari, V.; Colina, Matteo; Ciancìo, Giovanni; Govoni, Marcello; Trotta, Francesco

doi:10.1007/s00296-009-1291-y

Cited by 96 publications

(85 citation statements)

References 43 publications

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“…Arthritis can be initially mild, and transient oligoarticular form [22], but it can turn into a more serious form, destructive, symmetric and polyarticular over a period of several months [8].…”

Section: Discussionmentioning

confidence: 99%

Adult Onset Still’s Disease: Articular Manifestations in Twenty Cases

Mahfoudhi¹,

Gorsane²,

Battikh³

et al. 2015

OJCD

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The adult onset Still's disease is a rare inflammatory pathology of unknown pathogeny. The clinical features are variable. The diagnosis is difficult since exclusion of infectious, systemic and tumoral pathologies should be done. The articular complications are frequent and can be revelatory of this pathology. The articular prognosis depends on the diagnosis delay and the treatment efficiency. Our study aims to analyze different aspects of articular manifestations complicating adult onset Still's disease to define epidemiological, clinical and evolving characteristics of these complications. It was a cross-sectional study concerning 20 cases of adult onset Still's disease diagnosed from 1990 to 2015 in the internal medicine A department of Charles Nicolle Hospital in Tunis, meeting Yamaguchi criteria. We identified clinical, radiological, evolving and therapeutic profile of the articular manifestations occurred in these patients. There were 13 women and 7 men. The average age was 25 years. The arthralgias were reported in all cases; while, the arthritis interested fifteen patients. A hand deformation was found in four patients. A wrist ankylosis was noted in one case and a flexion elbow in one patient. The standard articular radiographs were normal in twelve cases. The treatment associated essentially non-steroidal anti-inflammatory and/or corticosteroids and/or methotrexate. Concerning the evolving profile, the monocyclic form was pre-sent in 25% of the cases, the intermittent form in 45% and the chronic articular form in 30% of our patients. The adult onset Still's disease is rare and heterogeneous. The articular disturbances are frequent and have various outcomes.

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Section: Discussionmentioning

confidence: 99%

Adult Onset Still’s Disease: Articular Manifestations in Twenty Cases

Mahfoudhi¹,

Gorsane²,

Battikh³

et al. 2015

OJCD

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show abstract

“…Tipik deri döküntüsü, diğer otoimmün ve enflamatuvar hastalıklara göre daha yüksek ferritin düzeyi önemli bulgulardandır. [8] 1000 μg/L üzerindeki ferritin düzeyleri bir çok çalışmada hastalığı belirlemek için kullanılmıştır. [9] Eşlik eden demir eksikliği anemisi varlığında serum ferritini normal veya hafif yüksek düzeyde kalabilir.…”

Section: Discussionunclassified

An Adult Onset Still's Disease with Normal Ferritin Level

Erdem¹,

Akın²,

Ozal³

et al. 2014

J Kartal TR

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“…City Hospital with normal range 23-110 μg/l; University Hospital with normal range 13-150 μg/). In the literature other normal values (40-200 μg/l) have been indicated [3]. These differences might be caused by the properties of the different methods of analysis or device-specific conditions.…”

Section: Discussionmentioning

confidence: 99%

“…Elevated levels of serum ferritin can be detected in various diseases such as infections, malignancies, liver diseases like haemochromatosis or Gaucher's disease, and in the haemophagocytic syndrome [3,4]. Except in the haemophagocytic syndrome serum ferritin levels in AOSD are usually much higher than in any other autoimmune or inflammatory diseases.…”

Section: Discussionmentioning

confidence: 99%