Adult-onset Still's disease preceding Crohn's disease

Κατσάνος, Κωνσταντίνος; Siozopoulou, Vasiliki; Sigounas, Dimitrios E.; Tsianos, Vasileios E.; Christodoulou, Dimitrios; Mitsi, Vasiliki; Tsianos, Epameinondas V.

doi:10.1016/j.crohns.2012.05.019

Cited by 11 publications

(9 citation statements)

References 16 publications

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“…The occurrence of JIA and CD is rare, especially in children below the age of 16 years. [16789101112] To the best of the authors' knowledge, this is the first report of the coexistence of these two conditions in a Nigerian child.…”

Section: Discussionmentioning

confidence: 88%

“…Previous reports on JIA and CD have revealed 12 cases in Caucasian children between 1994 and 2011,[1910111213] but there remains a paucity of data on the occurrence of these conditions in black African children. These reports reveal that the interval between the diagnosis of arthritis and the development of CD is highly variable [Table 1].…”

Section: Discussionmentioning

confidence: 99%

“…Determinants of the onset of CD following the diagnosis of JIA are unclear but may possibly be related to the type and severity of arthritis, other genetic, and environmental factors – HLA-B27 gene. [14910] It is important to look out for GI symptoms, and other symptoms such as fever, jaundice, and side effects of drug therapy when treating JIA patients.…”

Section: Discussionmentioning

confidence: 99%

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Development of crohn's disease following treatment for juvenile idiopathic arthritis in a nigerian child: Case report and review of literature

et al. 2019

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Juvenile idiopathic arthritis (JIA) and Crohn's disease (CD) are diseases that are rarely seen in the black African child. CD has been reported to occur following therapy with etanercept in JIA patients. We report the case of a Nigerian child with JIA who developed CD following treatment for JIA. A 9-year-old male with JIA was referred to the pediatric gastroenterology unit of the Lagos University Teaching Hospital on the account of chronic diarrhea with occasional passage of bloody stools. He had been on prednisolone and methotrexate which had controlled the joint flares. Colonoscopy revealed extensive colitis, ulcers, abscesses, and ileocecal disease. Histology confirmed the CD. In view of the unavailability of the recommended treatment, namely biologics in the country and financial constraints; steroids; and sulfasalazine were added to his treatment regimen, and subsequently, he has made significant clinical improvement.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Development of crohn's disease following treatment for juvenile idiopathic arthritis in a nigerian child: Case report and review of literature

et al. 2019

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“…Similarly, an association between AOSD and other inflammatory diseases has been reported: Crohn's disease [53][54][55], sarcoidosis [56,57] and neutrophilic urticarial dermatosis (NUD) [58,59]. The latter is a rare form of dermatosis with clinical and biological features very similar to AOSD (high fever, skin eruption, arthralgia, biological inflammation, neutrophilic hyperleukocytosis).…”

Section: Aosd As a Said At The Crossroad Of Other (Auto) Inflammatory Disorders And Points Left Unresolvedmentioning

confidence: 89%

Clinical Phenotypes of Adult-Onset Still’s Disease: New Insights from Pathophysiology and Literature Findings

Mitrovic

Fautrel

2021

JCM

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Adult-onset Still’s disease (AOSD) is a non-familial, polygenic systemic autoinflammatory disorder. It is traditionally characterized by four cardinal manifestations—spiking fever, an evanescent salmon-pink maculopapular rash, arthralgia or arthritis and a white-blood-cell count (WBC) ≥ 10,000/mm3, mainly neutrophilic polymorphonuclear cells (PMNs)—but many other manifestations and complications can be associated, making clinical expression very heterogeneous and diagnosis sometimes difficult. The AOSD course can be diverse and is currently impossible to predict. Several clinical phenotypes have been described, either on the basis of the evolution of symptoms over time (monocyclic, polycyclic and chronic evolution) or according to dominant clinical evolution (systemic and arthritis subtypes). However, these patterns are mainly based on case series and not on robust epidemiological studies. Furthermore, they have mainly been established a long time ago, before the era of the biological treatments. Thus, based on our personal experience and on recent advances in the understanding of disease pathogenesis, it appears interesting to reshuffle AOSD phenotypes, emphasizing the continuum between AOSD profiles and other systemic autoinflammatory disorders, eventually proposing a research agenda.

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“…Concomitant diagnosis of IBDs and juvenile idiopathic arthritis is rare. Some cases of adult Still's disease in CD were described in literature, the first in 2003 (15), then only very few cases were reported (16,17).…”

Section: Musculoskeletal Involvementmentioning

confidence: 98%

Rheumatologic and extraintestinal manifestations of inflammatory bowel diseases

2016

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Inflammatory bowel diseases (IBDs) often present as a complex inflammatory process wherein colon lesions (ulcerative colitis, UC) or widespread ulceration and fissure (Crohn's disease, CD) might be accompanied by ancillary extraintestinal manifestations (EIMs) that could involve almost every organ system, but also by autoimmune disorders ranging from psoriasis and rheumatoid arthritis to connective tissue diseases. Certain EIMs are more common related to the activity of the IBD (joint, skin, ocular and oral manifestations), other EIMs typically run a course independent of the IBD activity (hepatobiliary disorders) and some are non-specific disorders (osteoporosis and amyloidosis). This paper reviews the most common extraintestinal and rheumatologic manifestations of UC and CD. They may produce greater morbidity than the underlying intestinal disease and may even be the initial presenting symptoms of the IBD. Thus, early recognition of these manifestations should help guide therapy that will reduce overall morbidity in affected patients. Key Message A complete review on the most common extraintestinal and rheumatologic manifestations of ulcerative colitis and Crohn's disease.

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Adult-onset Still's disease preceding Crohn's disease

Cited by 11 publications

References 16 publications

Development of crohn's disease following treatment for juvenile idiopathic arthritis in a nigerian child: Case report and review of literature

Development of crohn's disease following treatment for juvenile idiopathic arthritis in a nigerian child: Case report and review of literature

Clinical Phenotypes of Adult-Onset Still’s Disease: New Insights from Pathophysiology and Literature Findings

Rheumatologic and extraintestinal manifestations of inflammatory bowel diseases

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