Adult-Onset Still' s Disease Presenting as Fever of Unknown Origin in a Patient with HIV Infection

Delvecchio, S; Skidmore, Peter J.

doi:10.1086/526785

Cited by 11 publications

(4 citation statements)

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“…Other features include neutrophilia, lymphadenopathy, splenomegaly and signs of serositis. 3 Pulmonary manifestations, typically pleuritis and transient pulmonary infiltrates, have also been described. 6,7 While moderate abnormalities of liver biochemistry are reported frequently, 6,8 severe hepatitis (level of transaminases >five times normal) is less common (12–17% of patients) and acute hepatic failure requiring transplantation is rare.…”

Section: Discussionmentioning

confidence: 99%

An unusual cause of fever in an HIV-positive patient

et al. 2012

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Section: Discussionmentioning

confidence: 99%

An unusual cause of fever in an HIV-positive patient

et al. 2012

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“…Patogeneza AOSD jest złożona i nie do końca poznana. W rozwoju choroby bierze się pod uwagę czynniki środowiskowe, drobnoustroje (wirus różyczki [1], wirus zapalenia wątroby typu B i C [2,3], cytomegalowirus [4], wirus nabytego upośledzenia odporności HIV [5], parvowirus B19 [6], bakterie Mycoplasma pneumoniae [7], Chlamydia pneumoniae [8], Chlamydia trachomatis [9]) oraz czynniki genetyczne [10]. Wykazano związek między obecnością DRB1*15, DRB1*12 i HLA-DRB1*04 a występowaniem AOSD [11].…”

Section: Wstępunclassified

Multifocal granulocellulare tumor of the skin in a patient with adult-onset Still’s disease treated with adalimumab

Cieślak¹,

Hrycaj²

2014

Reumatologia

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Adult-onset Still's disease (AOSD) is a chronic disease marked by seronegative arthritis accompanied by the involvement of the internal organs. Typical symptoms including fever, arthritis, joint pain, and a distinctive salmon-colored rash, often accompanied by pharyngitis, enlarged liver and spleen, enlarged lymph nodes, acute pancreatitis, peritonitis, pleuritis and pericarditis have been described together with various additional symptoms. AOSD is treated with nonsteroidal anti-inflammatory drugs, steroids, disease modifying drugs and biologics (tumor necrosis factor antagonists). In this paper we present a case of a 59 year old man with AOSD treated with adalimumab, diagnosed with granulocellulare tumor of the skin in the course of therapy with the TNF antagonist.

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“…[29][30][31] Several reports have indicated the role of infectious factors but have not proved anything decisively. Viruses like rubella, [32] EpsteinBarr virus, [33] human herpes virus (HHV6), [34] hepatitis B and C, [35,36] parvovirus B19, [37] cytomegalovirus, [38] human immunodeÞ ciency virus (HIV); [39,40] and bacteria like Mycoplasma p n e u m o n i a , C h l a m y d i a p n e u m o n i a , Chlamydia trachomatis are considered to be risk factors. [41][42][43] Several cytokines have been described in the pathogenesis of AOSD, including interleukin (IL)-1, IL-6, tumor necrosis factoralpha (TNF-α) and IL-18.…”

Section: Pathogenesismentioning

confidence: 99%