Adult Orbital Lesions in Saudi Arabia: A Multi-centered Demographic Study with Clinicopathological Correlation

Alsalamah, Abrar K.; Maktabi, Azza; Alkatan, Hind M.

doi:10.2991/jegh.k.200720.001

Cited by 6 publications

(3 citation statements)

References 22 publications

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“…Therefore, this tumor is not commonly seen in ophthalmic practice. In a recent large study on 110 orbital lesions in adults in two tertiary eye centers, NPC was diagnosed as an orbital lesion in only 2 patients (29) . Following this, Alrashed et al specifically reported their experience with NPC patients complaining of variable clinical manifestations who presented to ophthalmologists for the first time (5) .…”

Section: Discussionmentioning

confidence: 99%

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Ophthalmic manifestations of nasopharyngeal carcinoma (NPC): a systematic review of reported cases with and without prior history of nasopharyngeal carcinoma

Alkatan,

Alrashed,

Maktabi

2024

ABO

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We aimed to study reported cases of nasopharyngeal carcinoma presenting with ophthalmic manifestations with and without a prior diagnosis of nasopharyngeal carcinoma. Methods: We conducted a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A literature search was conducted using the MEDLINE database in PubMed and Google Scholar. We included patients with a previous diagnosis of nasopharyngeal carcinoma in Group I and those without a prior diagnosis of nasopharyngeal carcinoma in Group II. Data included demographics, clinical presentation, history of nasopharyngeal carcinoma, treatment, histopathological description, World Health Organization classification, and outcome. Results: Fifty-eight patients (26 in Group I and 32 in Group II) were included. The male-to-female ratio was 3:1. The mean age of the patients (53.3 ± 11.7 years and 54.8 ± 16.2 years, respectively) and gender did not differ significantly between the two groups. The most common ocular presentations were diplopia and proptosis in the first group (each in 34.6%), whereas visual disturbance was most common in the second group (46.9%). Treatment options and World Health Organization grading were comparable. The outcome in 38 patients (after a comparable follow-up period) was significantly better in group II (p=0.003). There was no statistically significant difference in the outcome of 23 patients in correlation with World Health Organization grades II versus III irrespective of group (p=0.094). Conclusions: The demographics of patients with nasopharyngeal carcinoma presenting with ophthalmic manifestations were similar between the two study groups, with a wide age range and male predominance. Patients presenting initially to ophthalmologists with no history of nasopharyngeal carcinoma have a more favorable outcome. World Health Organization grading may have less value as a prognostic indicator.

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Section: Discussionmentioning

confidence: 99%

“…Considering the possible aggressive nature of this tumor with local infiltrative features, a high level of suspicion and appropriate imaging techniques using magnetic resonance imaging are essential for assessing and staging NPC according to the latest 8th American Joint Commission on Cancer (AJCC) staging system (28)(29)(30) .…”

Section: Discussionmentioning

confidence: 99%

Ophthalmic manifestations of nasopharyngeal carcinoma (NPC): a systematic review of reported cases with and without prior history of nasopharyngeal carcinoma

Alkatan,

Alrashed,

Maktabi

2024

ABO

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“…A number of tumours, infammatory lesions, and congenital lesions can afect the orbit. According to the site of occurrence, orbital lesions can be classifed as primary, secondary, or metastatic [1]. Orbital metastases are rare, and previous studies have reported that orbital metastases represent approximately 3∼7% of all orbital space-occupying lesions [2,3].…”

Section: Introductionmentioning

confidence: 99%

Clinical and Imaging Characteristics of Metastatic Orbital Tumours in North China

Zhao,

Yu,

et al. 2024

Journal of Ophthalmology

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Purpose. This study was designed to review the primary sites, clinical manifestations, imaging features, treatments, and outcomes of 36 patients with orbital metastasis in North China. Methods. This was a retrospective review of 36 patients with orbital metastasis at Tianjin Eye Hospital between January 2010 and December 2020 in North China as well as a review of the literature. Results. Thirty-six patients were included in the study; 17 were male, and 19 were female, with an age range of 1–82 years (average 54.9 ± 19.8 years). All the tumours were unilateral. The mean duration from the onset of orbital signs to presentation at the hospital was 2.4 months (range 1–10 months). Breast carcinoma, gastrointestinal tract carcinoma, and lung carcinoma were the most common histological types. Proptosis, ocular pain, and diplopia were the most common clinical manifestations. The superior orbit was the most common quadrant involved. All patients received comprehensive therapy, including surgery, radiotherapy, or chemotherapy. The average follow-up time was 2.45 years (range 7 months to 5.5 years). Ten patients in this study died as a result of disseminated metastasis from the primary tumour. Conclusions. In North China, the most common primary cancer that metastasizes to the orbit is breast cancer, followed by gastrointestinal tract carcinoma and lung cancer. The increasing trend of orbital gastrointestinal tract metastases in North China in recent years is noteworthy. The survival rate of patients with orbital metastasis of neuroblastoma is low.

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Ocular surface squamous neoplasia in India: a study of 438 patients

et al. 2022

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Adult Orbital Lesions in Saudi Arabia: A Multi-centered Demographic Study with Clinicopathological Correlation

Cited by 6 publications

References 22 publications

Ophthalmic manifestations of nasopharyngeal carcinoma (NPC): a systematic review of reported cases with and without prior history of nasopharyngeal carcinoma

Ophthalmic manifestations of nasopharyngeal carcinoma (NPC): a systematic review of reported cases with and without prior history of nasopharyngeal carcinoma

Clinical and Imaging Characteristics of Metastatic Orbital Tumours in North China

Ocular surface squamous neoplasia in India: a study of 438 patients

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