Adult ovarian granulosa cell tumors: analysis of outcomes and risk factors for recurrence

Plett, Helmut; Ricciardi, Enzo; Vacaru, V; Ramspott, J.P; Colombo, Nicoletta; Sehouli, Jalid; Bois, Andreas du; Garbi, Annalisa; Richter, Rolf; Ataseven, Beyhan; Aletti, Giovanni; Braicu, Elena Ioana; Heitz, Florian; Portuesi, Rosalba; Muallem, Mustafa Zelal; Dagres, T; Parma, Gabriella; Roser, Eva; Traut, Alexander; Multinu, Francesco; Harter, Philipp

doi:10.1136/ijgc-2022-003854

Cited by 8 publications

(1 citation statement)

References 25 publications

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“…[8][9][10][11][12] Cytotoxic platinum-based chemotherapy (CT) is recommended for treating metastatic or recurrent AOGCT. The objective response rates (RRs) to multiple combined chemotherapy regimens have been reported to range from 50% to 92%; [13][14][15] however, durable remission is infrequent. 16 Commonly, adjuvant CT is recommended for advanced AOGCT or high-risk early-stage tumors.…”

Section: Introductionmentioning

confidence: 99%

The Prognostic Significance of Adjuvant Chemotherapy in Adult Ovarian Granulosa Cell Tumors: A Systematic Review and Meta-analysis

Zhuang,

Yang

2023

Cancer Control

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Introduction This study aimed to evaluate the oncological and prognostic significance of adjuvant chemotherapy (CT) in patients with adult granulosa cell tumors of the ovary (AOGCT). Methods We searched the Chinese National Knowledge Infrastructure, Clinical Trials, Wanfang Database, Web of Science, Cochrane Library, and MEDLINE electronic databases for articles published up to May 2023. Reference lists of the enrolled studies, Google Scholar, and scientific meeting reports were also manually searched. Results We enrolled 5641 patients with AOGCT from 33 eligible studies, including 1674 (29.7%) and 3967 (70.3%) patients in the CT and non-CT groups, respectively. Based on the cumulative results, adjuvant CT did not affect the risk of recurrence or progression (R/P) (odds ratio [OR]: 1.67, 95% confidence interval [CI]: 1.01–2.78, I2 = 63%, P = .05) and 5-year overall survival (OR: .86, 95% CI: .70–1.04, I2 = 0%, P = .12) of patients with AOGCT. However, adjuvant CT might reduce the 5-year disease-free survival (OR: 2.90, 95% CI: 1.19–7.08, I2 = 55%, P = .02). Sub-group analysis revealed that adjuvant CT did not affect the risk of R/P in patients with early-stage AOGCT (OR: .78, 95% CI: .43–1.43, I2 = 2%, P = .43) and advanced or recurrent AOGCT (OR: .78, 95% CI: .43–1.43, I2 = 2%, P = .43). Conclusion This meta-analysis suggests that patients with AOGCT might not benefit from adjuvant CT, even those with advanced or recurrent disease. The results should be interpreted with caution because of the inherent limitations of retrospective studies.

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Section: Introductionmentioning

confidence: 99%

The Prognostic Significance of Adjuvant Chemotherapy in Adult Ovarian Granulosa Cell Tumors: A Systematic Review and Meta-analysis

Zhuang,

Yang

2023

Cancer Control

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Risk Factors and Clinical Outcomes of Recurrence in Adult Ovarian Granulosa Cell Tumors

Golmohammadi Tavallaee,

Hasanzadeh Mofrad,

Yousefi

et al. 2024

Cancer Reports

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PurposeGranulosa cell tumors (GCTs) of the ovary are rare but clinically significant malignancies. Despite advances in treatment, recurrence has remained a substantial challenge. This study aimed to identify clinical outcomes and potential prognostic risk factors for recurrence in patients diagnosed with GCTs.MethodsIn a retrospective cohort study, the ovarian cancer database of the gynecological tertiary referral cancer center, Mashhad University of Medical Sciences, Mashhad, Iran, was searched from August 2012 to August 2023 to find GCT cases. Demographic, clinical, pathological, intervention‐related factors, follow‐up, and survival findings were meticulously collected. Data were analyzed using SPSS v 23.ResultsNinety‐two patients with GCTs, including 86 AGCT and 6 JGCT subjects, were identified. Based on further analysis of AGCT patients, most patients were ages under 50 (58.1%), clinically presented pain (32.6%), and abnormal uterine bleeding (27.9%) as the most frequent symptoms. Stages IA (64.0%) and IC (20.9%) were common. Five‐year overall and progression‐free survival were 98.2% and 90.8%, respectively. With a median follow‐up time of 72 (0.0–180) months, disease recurrence was observed in 19 patients (23.9%), and five patients (5.4%) died of the disease. Stage IV was a hazard factor of recurrence (HR = 7.62, 95%CI (1.89–30.63); p = 0.004).ConclusionsThe present study provides valuable insights into the outcomes and potential risk factors for recurrence in ovarian AGCTs. It duplicates the importance of stage in the prognosis of AGCT patients and highlights the safety of fertility‐sparing surgery in stage I and the lack of need to administer chemotherapy in stage IC.

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Sensitivity of frozen section analysis in patients with ovarian adult granulosa cell tumor, a multi-center study

Ureyen,

Toptas,

Tokalıoğlu

et al. 2024

Arch Gynecol Obstet

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Adult ovarian granulosa cell tumors: analysis of outcomes and risk factors for recurrence

Cited by 8 publications

References 25 publications

The Prognostic Significance of Adjuvant Chemotherapy in Adult Ovarian Granulosa Cell Tumors: A Systematic Review and Meta-analysis

The Prognostic Significance of Adjuvant Chemotherapy in Adult Ovarian Granulosa Cell Tumors: A Systematic Review and Meta-analysis

Risk Factors and Clinical Outcomes of Recurrence in Adult Ovarian Granulosa Cell Tumors

Sensitivity of frozen section analysis in patients with ovarian adult granulosa cell tumor, a multi-center study

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