Adult Pilocytic Astrocytomas: A Brazilian Series

Boschetti, Gilles; Santos, Adrialdo José; Fermon, Kellen Paiva; Honório, Gustavo Lopes de Freitas; Batistella, Gabriel Novaes de Rezende; Kusma, Solena Ziemer; Stávale, João Norberto; Neto, Manoel Antônio de Paiva; Malheiros, Suzana Mária Fleury

doi:10.1016/j.wneu.2019.08.146

Cited by 10 publications

(9 citation statements)

References 14 publications

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“…However, 13% of their cohort were reported as ventricular tumors, without further speciﬁcations. Boschetti et al [ 3 ] showed the same with 73.9% supratentorial distribution in their adult APA cohort.…”

Section: Discussionmentioning

confidence: 72%

Adult Pilocytic Astrocytoma in the insula: Case report and review of the literature

Muhsen

Ghzawi

Hashem

et al. 2021

Annals of Medicine &Amp; Surgery

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Introduction and Importance: Adult Pilocytic Astrocytomas (APA) are infrequent low grade tumors. While supratentorial APA is considered rare, insular APA is extremely rare. Case presentation We present a case of pure insular APA along with surgical outcomes. Tractography and functional MRI were obtained pre-operatively. The patient underwent neuro-navigation guided microsurgical resection with sub-cortical white matter mapping, utilizing Intra-operative MRI guidance. The Sylvain fissure was opened to secure the M3 branches, and near total resection was achieved. Clinical discussion APA in the insula is a very rare presentation and is considered challenging. Its proximity to the middle cerebral and lenticulostriate arteries, motor areas, and language areas makes accessing and resecting the tumor challenging. A multidisciplinary approach by an experienced team is needed to plan the management of young adult patients and reach the best outcomes. Conclusion Implementing microsurgical techniques, modern imaging modalities and intraoperative mapping helps to achieve maximal safe resection without risking functions.

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Section: Discussionmentioning

confidence: 72%

Adult Pilocytic Astrocytoma in the insula: Case report and review of the literature

Muhsen

Ghzawi

Hashem

et al. 2021

Annals of Medicine &Amp; Surgery

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“…Ryu et al reported GTR in 55% of adults and 58% of pediatrics. More recent studies on adults reported GTR achievement ranging between 39 and 67% of their patients ( Table 3 ) [ 7 , 10 , 25 , 27 , 28 ]. In our cohort, GTR and NTR were achieved in 40% of patients.…”

Section: Discussionmentioning

confidence: 99%

Insight about the characteristics and surgical resectability of adult pilocytic astrocytoma: tertiary center experience

et al. 2022

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Aim: Adult pilocytic astrocytoma is a rare tumor. We aim to contribute to understanding its clinical course and prognosis. Patients & methods: We searched our database for patients older than 18 years with pathology-proven pilocytic astrocytoma. Patients’ clinical data were analyzed. Results: Fifteen patients were identified. The median age at diagnosis was 25 years (range: 18–56). Tumors were supratentorial in 47%. Gross-total and near-total resections were achieved in 40%, and sub-total resection in 47%. One (7%) recurrence and no mortality were encountered during a median follow-up of 11 months (range: 1–76). Conclusion: Pilocytic astrocytoma behaves differently in adults compared with pediatrics. It tends to arise in surgically challenging areas where the extent of resection may be limited. Total resection should be the main therapy whenever feasible. The survival rates are good, and recurrence is low.

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“…Pilocytic astrocytomas (PAs), which account for approximately 5% of all primary central nervous system tumors,[ 1 ] are classified by the World Health Organization (WHO) as Grade I astrocytomas. They are also the most common brain tumor found in children and adolescents.…”

Section: Background and Importancementioning

confidence: 99%

“…[ 6 ] These well-circumscribed, yet potentially infiltrative tumors are most commonly located close to the cerebellar midline in children, while in adults, they are found more laterally within the cerebellum or in the temporal and parietal lobes. [ 1 , 4 ] Less than 10% of PAs in adults involve the spinal cord. [ 5 ] Early diagnosis and complete resection have been shown to yield good prognosis for most pediatric cases.…”

Section: Background and Importancementioning

confidence: 99%

Intraspinal pilocytic astrocytomas: An overview and 2-D illustrative resection technique video

Ojukwu

Hoffman

Song

et al. 2022

Surgical Neurology International

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Background: Spinal cord pilocytic astrocytomas (PAs) are rare and typically occur in pediatric patients. While PAs are often well-circumscribed and amenable to gross total resection, they sometimes harbor infiltrative components that can invade normal cord parenchyma. Methods: Here, we present a 59-year-old female with a progressive right-sided hemi-sensory loss, right-sided hemiparesis, and gait imbalance. The preoperative T2 magnetic resonance imaging revealed a large loculated cystic tumor that focally compressed the dorsal medulla, while the contrast study revealed a 1.3 cm homogenously enhancing expansile intramedullary mass centered at the C1 level. Results: The patient underwent a C1-2 laminectomy followed by gross total intramedullary tumor resection utilizing intraoperative dorsal column mapping. There were no operative complications. The patient had preserved motor strength and an expected dorsal column dysfunction, which largely resolved over 9 months postoperatively. Conclusion: Here, we provide a broad overview of PAs, in addition to a case study/technical note that includes a 2-D intraoperative video detailing the resection technique.

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Adult Pilocytic Astrocytomas: A Brazilian Series

Cited by 10 publications

References 14 publications

Adult Pilocytic Astrocytoma in the insula: Case report and review of the literature

Adult Pilocytic Astrocytoma in the insula: Case report and review of the literature

Insight about the characteristics and surgical resectability of adult pilocytic astrocytoma: tertiary center experience

Intraspinal pilocytic astrocytomas: An overview and 2-D illustrative resection technique video

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