Adult rat's offspring of alcoholic mothers are impaired on spatial learning and object recognition in the Can test

Popovic, Marko; Caballero-Bleda, Marı́a; Guerri, Consuelo

doi:10.1016/j.bbr.2006.07.012

Cited by 38 publications

(24 citation statements)

References 69 publications

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“…Therefore, no extrapolations should be made with regards to the possible effects of ethanol exposure during the 3rd trimester equivalent and learning and memory abilities in females. In fact, learning and memory deficits are commonly observed in females following PNEE, particularly with 3rd trimester exposure [11,12,17]. …”

Section: Resultsmentioning

confidence: 99%

“…The hippocampus is one of the major brain regions affected in FASD [9], and both animals [10,11,12,13,14,15,16,17,18] and children [19,20,21,22] that were exposed to ethanol during the period of brain development show learning and memory impairments. Previous studies from our laboratory and others have also indicated that prenatal ethanol exposure can cause long lasting deficits in hippocampal synaptic plasticity [14,15,23,24,25,26,27].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Ethanol Exposure during Distinct Periods of Brain Development on Hippocampal Synaptic Plasticity

et al. 2013

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Fetal alcohol spectrum disorders occur when a mother drinks during pregnancy and can greatly influence synaptic plasticity and cognition in the offspring. In this study we determined whether there are periods during brain development that are more susceptible to the effects of ethanol exposure on hippocampal synaptic plasticity. In particular, we evaluated how the ability to elicit long-term potentiation (LTP) in the hippocampal dentate gyrus (DG) was affected in young adult rats that were exposed to ethanol during either the 1st, 2nd, or 3rd trimester equivalent. As expected, the effects of ethanol on young adult DG LTP were less severe when exposure was limited to a particular trimester equivalent when compared to exposure throughout gestation. In males, ethanol exposure during the 1st, 2nd or 3rd trimester equivalent did not significantly reduce LTP in the DG. In females, ethanol exposure during either the 1st or 2nd trimester equivalents did not impact LTP in early adulthood, but following exposure during the 3rd trimester equivalent alone, LTP was significantly increased in the female DG. These results further exemplify the disparate effects between the ability to elicit LTP in the male and female brain following perinatal ethanol exposure (PNEE).

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Ethanol Exposure during Distinct Periods of Brain Development on Hippocampal Synaptic Plasticity

et al. 2013

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“…Rodent literature does suggest that age ameliorates, but does not completely reverse, MWM learning and memory deficits (Gianoulakis, 1990; Wagner et al, 2014; Wozniak et al, 2004). Other spatial tasks, including the Barnes maze and can- task, also show learning and memory deficits that are dependent upon both task difficulty and age of the animal (Kleiber, Wright, & Singh, 2011; Popović, Caballero-Bleda, & Guerri, 2006). The more complex radial-arm maze task reveals deficits in juvenile mice (Reyes, Wolfe, & Savage, 1989), but not in 3-month-old mice (Sluyter, Jamot, Bertholet, & Crusio, 2005) with dose-dependent effects.…”

Section: Learning Memory and Executive Control (Cognitive)mentioning

confidence: 99%

The impact of prenatal alcohol exposure on social, cognitive and affective behavioral domains: Insights from rodent models

Marquardt

Brigman

2016

Alcohol

129

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Fetal Alcohol Spectrum Disorders (FASD) are characterized by deficits in working memory, response inhibition, and behavioral flexibility. However, the combination and severity of impairments are highly dependent upon maternal ethanol consumption patterns, which creates a complex variety of manifestations. Rodent models have been essential in identifying behavioral endpoints of prenatal alcohol exposure (PAE). However, experimental model outcomes are extremely diverse based on level, pattern, timing, and method of ethanol exposure, as well as the behavioral domain assayed and paradigm used. Therefore, comparisons across studies are difficult and there is currently no clear comprehensive behavioral phenotype of PAE. This lack of defined cognitive and behavioral phenotype is a contributing factor to the difficulty in identifying FASD individuals. The current review aims to critically examine preclinical behavioral outcomes in the social, cognitive, and affective domains in terms of the PAE paradigm, with a special emphasis on dose, timing, and delivery, to establish a working model of behavioral impairment. In addition, this review identifies gaps in our current knowledge and proposes future areas of research that will advance knowledge in the field of PAE outcomes. Understanding the complex behavioral phenotype, which results from diverse ethanol consumption will allow for development of better diagnostic tools and more critical evaluation of potential treatments for FASD.

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“…Popovic and colleagues (177) subjected PNEE offspring exposed to gestational ethanol in a liquid diet and/or the early postnatal period to an extensive battery of memory tasks to evaluate performance in spatial learning, orientation, and simple and more complex object recognition. Generally, ethanol-exposed offspring performed poorly, though the impairments in these animals became increasingly evident as the task difficulty increased, with animals treated during the early postnatal period performing worse than others (177). …”

Section: Behavioral Manipulationsmentioning

confidence: 99%

A Comparison of the Different Animal Models of Fetal Alcohol Spectrum Disorders and Their Use in Studying Complex Behaviors

2014

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Prenatal ethanol exposure (PNEE) has been linked to widespread impairments in brain structure and function. There are a number of animal models that are used to study the structural and functional deficits caused by PNEE, including, but not limited to invertebrates, fish, rodents, and non-human primates. Animal models enable a researcher to control important variables such as the route of ethanol administration, as well as the timing, frequency and amount of ethanol exposure. Each animal model and system of exposure has its place, depending on the research question being undertaken. In this review, we will examine the different routes of ethanol administration and the various animal models of fetal alcohol spectrum disorders (FASD) that are commonly used in research, emphasizing their strengths and limitations. We will also present an up-to-date summary on the effects of prenatal/neonatal ethanol exposure on behavior across the lifespan, focusing on learning and memory, olfaction, social, executive, and motor functions. Special emphasis will be placed where the various animal models best represent deficits observed in the human condition and offer a viable test bed to examine potential therapeutics for human beings with FASD.

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Adult rat's offspring of alcoholic mothers are impaired on spatial learning and object recognition in the Can test

Cited by 38 publications

References 69 publications

Effects of Ethanol Exposure during Distinct Periods of Brain Development on Hippocampal Synaptic Plasticity

Effects of Ethanol Exposure during Distinct Periods of Brain Development on Hippocampal Synaptic Plasticity

The impact of prenatal alcohol exposure on social, cognitive and affective behavioral domains: Insights from rodent models

A Comparison of the Different Animal Models of Fetal Alcohol Spectrum Disorders and Their Use in Studying Complex Behaviors

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