Adult renal cell carcinoma with rhabdoid differentiation: incidence and clinicopathologic features in Chinese patients

Yang, Xinyu; Xi, Chenguang; Jin, Jie; Zhou, Liqun; Su, Jialin; Liu, Libo; Liu, Yuli

doi:10.1016/j.anndiagpath.2015.01.006

Cited by 11 publications

(19 citation statements)

References 18 publications

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“…The incidence of rhabdoid features was reported in approximately 1.4-7.4% of all RCCs [3,4,5,6,7,8,9]. We reported previously that the biological behavior of RCCs with rhabdoid features is highly aggressive and presents a very poor prognosis [5], which has been confirmed by other investigators [7,8,9,10]. Rhabdoid features were identified in several RCC histological subtypes, most commonly observed in clear cell RCC (ccRCC) [11], the most conventional histopathological subtype [12].…”

Section: Introductionsupporting

confidence: 72%

Epithelial to Mesenchymal Transition in Clear Cell Renal Cell Carcinoma with Rhabdoid Features

et al. 2016

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Aims: The aims of this study were to investigate the association of renal cell carcinoma (RCC) displaying rhabdoid features and morphologically mesenchymal characteristics with epithelial to mesenchymal transition (EMT), and to clarify the expression of EMT markers. Methods: We investigated the expression of EMT markers (E-cadherin, vimentin, Snail, Slug, ZEB1, ZEB2 and Twist1) using immunohistochemistry, Western blotting and real-time polymerase chain reaction in 18 cases of clear cell RCC (ccRCC) with rhabdoid features and 74 ccRCC cases with Fuhrman grade 1-3 (G1 to G3). Results: In ccRCCs with rhabdoid features, low E-cadherin and high vimentin expression were found. In G1 to G3 ccRCCs, low E-cadherin expression and high expression of vimentin, ZEB1 and ZEB2 were found. There was no significant difference in the immunoexpression of E-cadherin and vimentin between the two ccRCC groups. Conclusions: The rhabdoid features may histologically and biologically be associated with EMT in ccRCC. There is a possibility that in G1 to G3 ccRCCs showing epithelial structures, other cell-cell adhesion mechanisms apart from E-cadherin adhesion may continue to work, and that ccRCC with rhabdoid features may be caused by an inactivation or loss of these mechanisms.

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Section: Introductionsupporting

confidence: 72%

Epithelial to Mesenchymal Transition in Clear Cell Renal Cell Carcinoma with Rhabdoid Features

et al. 2016

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“…Extra renal adult type rhabdoid tumor as it pertains of soft tumor with prominent rhabdoid morphology and in which no other clear line of differentiation documented. 3 Clinically extra renal adult type rabdoid tumor often occur over a much broader age group range than those found in the kidney, although these lesion are far most often in children, occasionally arising as congenital lesions. 3 Extra renal adult type rhabdoid tumor most commonly metastasizes to lung, lymph node, liver in there are stage of disease.…”

Section: Discussionmentioning

confidence: 99%

“…1 Subsequently, the tumor with a histologic appearance similar to that of tumors arising in the kidney have been described the skin, soft tissue, gastrointestinal tract, liver, thymus, urogenital tract, thymus and mostly the Central nervous system among others. 3 Oil red stain is positive for glycogen vacuoles. Crossstriations can be seen in some cases.…”

Section: Pathological Findingsmentioning

confidence: 99%

Rhabdoid tumor of cheek in an adult patient: A rare case report

Verma

Zaidi²,

Irfan³

et al. 2022

ACHR

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Rhabdoid tumor is relatively rare highly malignant tumor in adult older than 40 years, therefore treatment regimens often throwing from pediatric age group. It is characterized by extremely aggressive behavior, rapid metastasis to other organ, low survival rate and no targeted therapy. So, early diagnosis is necessary for better treatment and reduce mortality outcome. A 42 years male suffering from a right side cheek mass of 5x3cm associated with tongue displacement to left side and difficulty in swallowing. After complete removal of lesion for histopathological examination, revealed grossly the tumor is well defined gray-white, round, lobulated 5x3cm in size having infiltrating borders. Cut surface shows gray-white to gray-brown, solid areas. Microscopically H&E stained section revealed, sheets of tightly packed large, discohesive, polygonal cells having abundant eosinophilic cytoplasm with eccentrically placed round nuclei showing distinct prominent vesicular nucleoli separated by thin fibrous septae with blood vessels. These cells lie in myxoid background. These tumor cells have deeply acidophilic having finely granular abundant cytoplasm with small, peripherally placed nuclei and abundant intra-cytoplasmic vacuoles along with nuclear pleomorphic, no mitotic figure seen. Histologically, the adult type tumor proliferating as sheet of tightly packed large, discohesive, polygonal cells having abundant eosinophilic cytoplasm with eccentrically placed round nuclei showing distinct prominent vesicular nucleoli separated by thin fibrous septae with blood vessels lie in fibromyxoid background. These tumor cells have deeply acidophilic, finely granular cytoplasm with small, peripherally placed nuclei with occasional intra-cytoplasmic vacuoles along with cross striations, no mitotic figures seen. Study concludes that adult type Rhabdoid tumors have extremely aggressive behavior, rapid metastasis spread to other organs, low survival rate and no targeted therapy. Usually males older than 40years of age are affected. It is crucial to make a rapid correct diagnosis and early treatment may improve the outcome.

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“…The presence of syncytial cells in CCRCC was also associated with poor prognosis in a subsequent study (13), while earlier, the rhabdoid phenotype was compared in prognostic terms to sarcomatoid transformation (14). Very recent studies confirm the adverse effect of rhabdoid differentiation in the prognosis of CCRCC (15)(16)(17)(18). At least in theory, a tumor is initially homogeneous and changes at some point in its development.…”

Section: Morphological Heterogeneitymentioning

confidence: 96%

Intratumor heterogeneity in clear cell renal cell carcinoma: a review for the practicing pathologist

López

2016

APMIS

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Intertumor heterogeneity, defined as the spectrum of morphological differences found in similar tumors in different patients, is a well-known event for pathologists. However, recent molecular studies have pointed to intratumor heterogeneity as one of the most important issues in human neoplasia in the next years. Clear cell renal cell carcinoma is an example of an intrinsically heterogeneous neoplasm, and some of the most salient advances in the knowledge of intratumor heterogeneity have been developed on it. This review intends to analyze this phenomenon in this tumor from the practicing pathologist's point of view. A careful study of the surgical specimen and an exhaustive tumor sampling are mandatory to keep relevant information. Currently accepted protocols designed for renal tumor sampling may be insufficient. As a result, a different approach to tumor sampling is advisable to ascertain that intratumor heterogeneity, if present, will be well represented in the selected material.

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Adult renal cell carcinoma with rhabdoid differentiation: incidence and clinicopathologic features in Chinese patients

Cited by 11 publications

References 18 publications

Epithelial to Mesenchymal Transition in Clear Cell Renal Cell Carcinoma with Rhabdoid Features

Epithelial to Mesenchymal Transition in Clear Cell Renal Cell Carcinoma with Rhabdoid Features

Rhabdoid tumor of cheek in an adult patient: A rare case report

Intratumor heterogeneity in clear cell renal cell carcinoma: a review for the practicing pathologist

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