Adult rhabdomyosarcoma: Clinical presentation, treatment, and outcome

Khosla, Divya; Sapkota, Simit; Kapoor, Rakesh; Kumar, Ritesh; Sharma, Suresh C.

doi:10.4103/0973-1482.144637

Cited by 31 publications

(32 citation statements)

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“…5 In adults, the more frequent places have not been described with the same precision; Khosla and cols, describe similar places to the pediatric ones, although the authors mention other places with more frequency. 3,6,7 Due to its histologic characteristics, it can be grouped in the classification of small round and blue cells, because with the staining hematoxilin-eosin, we observe multiple cells with big dark blue nucleus with reduced cytoplasm. 6 It is necessary to observe through the microscope the striations of the skeletal muscle and an essential part includes visualization of the muscle's own proteins, such as desmin, actin, myoglobin, myosin and MyoD.…”

Section: Discussionmentioning

confidence: 91%

“…3,6,7 Due to its histologic characteristics, it can be grouped in the classification of small round and blue cells, because with the staining hematoxilin-eosin, we observe multiple cells with big dark blue nucleus with reduced cytoplasm. 6 It is necessary to observe through the microscope the striations of the skeletal muscle and an essential part includes visualization of the muscle's own proteins, such as desmin, actin, myoglobin, myosin and MyoD. 3,4 The rhabdomyosarcoma histopathology classification is done based on cellular differentiation, growth pattern and the extension of cells of embryonic, alveolar and pleomorphic types.…”

Section: Discussionmentioning

confidence: 91%

“…However, a medical-surgical treatment with chemotherapy has increased the survival rate up to 5 years in 45% of the cases, and there is evidence that in some cases, the response rate to chemotherapy in adults is similar to pediatric patients. 6,7,9,10 …”

Section: Discussionmentioning

confidence: 99%

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Adult with colon alveolar rhabdomyosarcoma

Adolfo¹,

Rafael²,

Viviana³

et al. 2018

Int Surg J

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The Purpose of the present study is to present a case of alveolar rhabdomyosarcoma in an 81-year-old patient. An 81-year-old woman presents changes in bowel habits, as well as a mobile mass in the abdomen, fixed to deep planes. Resection is performed. Immunohistochemistry was positive to Myo D1, Anti CD99 and Synaptophysin. Rhabdomyosarcoma may be present in adults, for which it should be discarded in case of small round blue cell tumors. Immunohistochemistry is useful to make a differential diagnosis of the tumor. Survival rates rises when using chemotherapy and surgery.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 91%

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Adult with colon alveolar rhabdomyosarcoma

Adolfo¹,

Rafael²,

Viviana³

et al. 2018

Int Surg J

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“…Approximately only 350 new cases diagnosed with RMS in United States each year, and mostly children under 20 years. Adult RMS differs from childhood RMS in terms of natural history, behavior, poor response to treatment, prognosis, and outcome [1]. In children and adolescents, embryonal and alveolar subtypes of RMS predominate.…”

Section: Discussionmentioning

confidence: 99%

“…This type of RMS tends to affect adults, with peak incidence in the fifth decade of life. It most commonly arises in deep soft tissues of the extremities [1] [2].…”

Section: Introductionmentioning

confidence: 99%

Successful Treatment of Adult Pleomorphic Rhabdomyosarcoma in the Posterior Left Femur: A Case Report

Sutedja¹,

Muthalib²,

Rinaldi³

et al. 2018

IJCM

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Introduction: Rhabdomyosarcoma (RMS) is the most common childhood soft tissue sarcoma, but it represents only a small portion of soft tissue sarcoma in adult population. There is a treatment protocol based on Intergroup Rhabdomyosarcoma Study (IRS) that provides satisfactory results in treating RMS in children, but there is only limited evidence regarding the outcome and prognosis in extrapolating the IRS protocol to treat RMS in adults. We report a case of adult pleomorphic RMS treated with multidisciplinary approach and the results we have obtained. Case presentation: A 48-year-old woman was admitted in February 2011 due to a painful mass on her left thigh. Diagnosis of pleomorphic rhabdomyosarcoma was made by histopathology and immunohistochemistry. After multimodal treatment that includes Trans-Arterial Chemotherapy Infusion, Cryosurgery, and wide excision surgery, our patient remains disease-free as of the latest annual follow up examination on June 2017. Conclusions: The pleomorphic type of Rhabdomyosarcoma is very rare in adults and is often associated with a poor prognosis. In our case, a multidisciplinary approach with multimodal treatment provides excellent result, even after a routine follow up spanning through six years.

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Multimodality Treatment Outcome in Adult Patients with Head and Neck Rhabdomyosarcoma

Wang,

Huang,

Wang

et al. 2024

The Laryngoscope

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Objective(s)Head and neck rhabdomyosarcoma (HNRMS) is a rare malignant tumor in adults. No standard treatment for adults with HNRMS currently exists.MethodsA retrospective study of 72 newly diagnosed consecutive adult patients with HNRMS was conducted at one institution between November 2010 and April 2023. The log‐rank tests were used to compare the differences in survival between treatment groups, and overall survival (OS), local recurrence‐free survival (LRFS), progression‐free survival (PFS), and distant metastasis‐free survival (DMFS) were calculated using the Kaplan–Meier method. We used restricted cubic spline models fitted for Cox proportional hazards models to determine the association between chemotherapy cycles/radiotherapy dose and mortality.ResultsThe 2‐year OS, PFS, LRFS, and DMFS rates for the entire cohort were 51.0%, 39.2%, 44.3%, and 47.3%, respectively. Radiotherapy significantly improved the OS (p < 0.01), PFS (p < 0.01), LRFS (p < 0.01), and DMFS (p < 0.01). Surgery had no effect on OS (49.3% vs. 53.0%, p = 0.62), PFS (36.9% vs. 41.8%, p = 0.31), LRFS (41.6% vs. 47.4%, p = 0.27), or DMFS (44.4% vs. 50.2%, p = 0.43). The restricted cubic spline showed that eight (HR = 1.002, 95% CI: 0.996–1.007) cycles of chemotherapy and 62.5Gy radiation therapy resulted in the lowest mortality.ConclusionFor HNRMS, eight cycles of chemotherapy and 62.5Gy of radiation might be sufficient. Poor response to chemotherapy predicted an extreme worse outcome. Surgery played a limited role in the treatment.Level of EvidenceIII Laryngoscope, 2024

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Adult rhabdomyosarcoma: Clinical presentation, treatment, and outcome

Abstract: RMS in adults have poor prognosis as compared to childhood RMS. Adult RMS should therefore be treated aggressively with multidisciplinary approach comprising of surgery, radiation, and chemotherapy to achieve cure and prolonged survival.

Cited by 31 publications

References 0 publications

Adult with colon alveolar rhabdomyosarcoma

Adult with colon alveolar rhabdomyosarcoma

Successful Treatment of Adult Pleomorphic Rhabdomyosarcoma in the Posterior Left Femur: A Case Report

Multimodality Treatment Outcome in Adult Patients with Head and Neck Rhabdomyosarcoma

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