Adult stem cells: Simply a tool for regenerative medicine or an additional piece in the puzzle of human aging?

Tollervey, James; Lunyak, Victoria V.

doi:10.4161/cc.10.24.18832

Cited by 15 publications

(11 citation statements)

References 20 publications

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“…As an important factor, the choice of the seeding cells is critical for its proliferative and differentiation potential in maintaining the extracellular matrix and the function of the cartilage (17). Adult stem cells have multi-lineage differentiation potential, which could be applied in multiple tissue-engineering strategies (18). Adult stem cells are potentially useful in promoting bone healing (19), tendon injury (20), intervertebral disc degeneration (21) and cartilage injury (22), and hold promising prospects in cartilage regeneration.…”

Section: Discussionmentioning

confidence: 99%

Effect of autologous platelet-rich plasma on the chondrogenic differentiation of rabbit adipose-derived stem cells in vitro

Tang

Dong

Wang

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. This study aimed to isolate rabbit adipose-derived stem cells (ADSCs) and explore the potential of platelet-rich plasma (PRP) in the chondrogenic differentiation of ADSCs, thereby potentially providing a new approach for the repair and regeneration of cartilage injury. Rabbit ADSCs were isolated and characterized by induction towards adipogenic, osteogenic and chondrogenic lineages in vitro. The isolated ADSCs were also cultured with or without 10% PRP. Immunofluorescence staining, toluidine blue staining and reverse transcription-quantitative polymerase chain reaction (RT-qPCR) were used to detect type II collagen (Col II) and aggrecan (AGC) expression. Col II immunofluorescence staining and toluidine blue staining indicated that following induction by autologous PRP, ADSCs manifested Col II and AGC expression. The expression of Col II and AGC mRNA was significantly upregulated in the PRP-treated cells when compared with that in control cells. Autologous PRP produced by laboratory centrifugation was able to promote the chondrogenic differentiation of rabbit ADSCs in vitro.

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Section: Discussionmentioning

confidence: 99%

Effect of autologous platelet-rich plasma on the chondrogenic differentiation of rabbit adipose-derived stem cells in vitro

Tang

Dong

Wang

et al. 2015

Experimental and Therapeutic Medicine

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“…36, 49 The restored T H 1/T H 2 balance has been shown to improve tissue regeneration in cartilage, muscle and other soft tissue injuries, alleviate symptoms of autoimmune diseases and have an anti-diabetic effect. 50, 51, 52, 53, 54 Similarly, reduction in INF-γ and secretion of IL-4 promotes a shift in macrophages from M1 (pro-inflammatory, anti-angiogenic and tissue growth inhibition) to M2 (anti-inflammatory, pro-remodeling and tissue healing) type, an effect required for skeletal, muscular and neural healing and regeneration. 46, 52, 55, 56, 57, 58 …”

Section: Identification and Biology Of Mscsmentioning

confidence: 99%

Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine

2013

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Mesenchymal stem cells (MSCs) are partially defined by their ability to differentiate into tissues including bone, cartilage and adipose in vitro, but it is their trophic, paracrine and immunomodulatory functions that may have the greatest therapeutic impact in vivo. Unlike pharmaceutical treatments that deliver a single agent at a specific dose, MSCs are site regulated and secrete bioactive factors and signals at variable concentrations in response to local microenvironmental cues. Significant progress has been made in understanding the biochemical and metabolic mechanisms and feedback associated with MSC response. The anti-inflammatory and immunomodulatory capacity of MSC may be paramount in the restoration of localized or systemic conditions for normal healing and tissue regeneration. Allogeneic MSC treatments, categorized as a drug by regulatory agencies, have been widely pursued, but new studies demonstrate the efficacy of autologous MSC therapies, even for individuals affected by a disease state. Safety and regulatory concerns surrounding allogeneic cell preparations make autologous and minimally manipulated cell therapies an attractive option for many regenerative, anti-inflammatory and autoimmune applications.

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“…Epigenetic modifications are heritable changes, such as DNA methylation, post‐translational modification of histones, chromatin remodelling or noncoding RNA expression that occur over life and affect gene expression without actually changing the DNA sequence (Holliday & Pugh, ; Wolffe & Guschin, ). Many of these epigenetic changes are necessary for normal cellular development and differentiation, involving stem cells, but abnormalities may also occur due to inappropriate epigenetic signalling (Tollervey & Lunyak, , ). Epigenetic changes are induced by physiological and pathological conditions as well as environmental (Aguilera et al .…”

Section: Introductionmentioning

confidence: 99%

‘Adipaging’: ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue

Pérez

Pareja‐Galeano

Sanchís-Gomar

et al. 2016

The Journal of Physiology

168

113

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The increasing ageing of our societies is accompanied by a pandemic of obesity and related cardiometabolic disorders. Progressive dysfunction of the white adipose tissue is increasingly recognized as an important hallmark of the ageing process, which in turn contributes to metabolic alterations, multi‐organ damage and a systemic pro‐inflammatory state (‘inflammageing’). On the other hand, obesity, the paradigm of adipose tissue dysfunction, shares numerous biological similarities with the normal ageing process such as chronic inflammation and multi‐system alterations. Accordingly, understanding the interplay between accelerated ageing related to obesity and adipose tissue dysfunction is critical to gain insight into the ageing process in general as well as into the pathophysiology of obesity and other related conditions. Here we postulate the concept of ‘adipaging’ to illustrate the common links between ageing and obesity and the fact that, to a great extent, obese adults are prematurely aged individuals.

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Adult stem cells: Simply a tool for regenerative medicine or an additional piece in the puzzle of human aging?

Cited by 15 publications

References 20 publications

Effect of autologous platelet-rich plasma on the chondrogenic differentiation of rabbit adipose-derived stem cells in vitro

Effect of autologous platelet-rich plasma on the chondrogenic differentiation of rabbit adipose-derived stem cells in vitro

Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine

‘Adipaging’: ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue

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