Adult Survivors of Childhood Cancer

Psychological risk in long‐term survivors of childhood acute lymphoblastic leukemia and its association with functional health status: A PETALE cohort study

“…LAEs include metabolic dysfunctions, musculoskeletal morbidities, cardiopulmonary, and neurocognitive impairments. [2][3][4][5][6][7][8][9][10][11][12][13][14] A report on the Childhood Cancer Survivor Study (CCSS) has estimated that 62% of surveyed adult survivors had at least one chronic health condition and 28% suffered from a severe condition. 5 Furthermore, the St-Jude Lifetime Cohort study found that the cumulative burden of chronic health conditions among adult childhood cancer survivors (CCS) compared with a community sample was also significantly higher with a high frequency of secondary neoplasms, spinal disorders, and pulmonary function deficits.…”

“…8,20,22,23,29,[33][34][35][36][37][38][39][40] Physical limitations may hinder age-appropriate activities, lead to difficulties in social relationships, and thus to psychological suffering. 7,9,[41][42][43] Particularly, impaired neurocognitive speed and executive function may affect emotional wellbeing as they hinder social functioning and are associated with lower educational attainment, employment discrimination, and unemployment. 9,[44][45][46] In summary, although it is widely recognized that LAEs may have a detrimental impact on quality of life and mental health, it is still unclear which domains are most important for psychological outcomes.…”

“…Several studies have highlighted how radiation therapy exposure, chemotherapy toxicity, as well as sex and age at diagnosis may be contributing factors to late adverse effects (LAEs) for survivors. LAEs include metabolic dysfunctions, musculoskeletal morbidities, cardiopulmonary, and neurocognitive impairments . A report on the Childhood Cancer Survivor Study (CCSS) has estimated that 62% of surveyed adult survivors had at least one chronic health condition and 28% suffered from a severe condition .…”

“…Key factors of emotional distress frequency or severity supported by the evidence in the CCS population include younger age or adolescent age at diagnosis, older age at recall, female sex, lower socioeconomic status, single or divorced status, lack of health insurance, poor social relationships, neurocognitive impairment, pain, fatigue, chronic condition, and an overall perception of health deterioration and physical health status . Physical limitations may hinder age‐appropriate activities, lead to difficulties in social relationships, and thus to psychological suffering . Particularly, impaired neurocognitive speed and executive function may affect emotional wellbeing as they hinder social functioning and are associated with lower educational attainment, employment discrimination, and unemployment .…”

Qualidade de Vida e Bem-Estar Subjetivo de Sobreviventes ao Câncer Ósseo: Percepção de Sobreviventes e Familiares

“…Mas, transformações satisfatórias também têm sido identificadas na vida dessas pessoas (Araujo & Arrais, 1998;Holland & Reznik, 2005;Pearce, Sanson-Fisher, & Campbell, 2008;Schwartz, Werba, & Kazak, 2010;Stanton, 2010).…”