Adult T-cell leukemia: clinical and hematologic features of 16 cases

Uchiyama, T; Yodoi, J; Sagawa, Kimitaka; Takatsuki, Kiyoshi; Uchino, Haruto

doi:10.1182/blood.v50.3.481.481

Cited by 1,700 publications

(203 citation statements)

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“…Human T-lymphotropic virus type 1 (HTLV-1) infection is estimated to affect 1 to 2 Â 10 7 people worldwide. Although HTLV-1 infection is lifelong, the majority of infected individuals remain asymptomatic; only 1% to 2% of these individuals develop HTLV-1Yassociated diseases, including adult T-cell leukemia/lymphoma (1), and a range of chronic inflammatory diseases, including myelopathy (2Y4), uveitis (5), arthritis (6), polymyositis (7,8), inclusion-body myositis (9,10), and alveolitis (11). The most recognized inflammatory disease is HTLV-1Yassociated myelopathy/tropical spastic paraparesis (HAM/TSP), in which CNS lesions correspond to progressive weakness of the lower extremities, with spasticity, urinary incontinence, and mild sensory disturbance.…”

Section: Introductionmentioning

confidence: 99%

Visualization of HTLV-1–Specific Cytotoxic T Lymphocytes in the Spinal Cords of Patients With HTLV-1–Associated Myelopathy/Tropical Spastic Paraparesis

Matsuura

Kubota

Tanaka

et al. 2015

J Neuropathol Exp Neurol

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Section: Introductionmentioning

confidence: 99%

Visualization of HTLV-1–Specific Cytotoxic T Lymphocytes in the Spinal Cords of Patients With HTLV-1–Associated Myelopathy/Tropical Spastic Paraparesis

Matsuura

Kubota

Tanaka

et al. 2015

J Neuropathol Exp Neurol

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“…Adult T-cell leukemia/lymphoma (ATLL) is a lymphoproliferative disorder caused by the retrovirus human T-lymphotropic virus type 1 (HTLV-1). [1][2][3] The tumor typically consists of oligoclonal or monoclonal outgrowth of CD4 1 CD25 1 T lymphocytes carrying a complete or defective provirus of HTLV-1. ATLL is classified into clinical subtypes, each with a different course and prognosis.…”

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confidence: 99%

FoxP3⁺ regulatory T cells are distinct from leukemia cells in HTLV‐1–associated adult T‐cell leukemia

Toulza

Nosaka

Takiguchi

et al. 2009

Intl Journal of Cancer

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Human T‐lymphotropic virus type 1 (HTLV‐1) is the causative agent of adult T‐cell leukemia/lymphoma (ATLL). It has been postulated that ATLL cells might act as regulatory T cells (Tregs) which, in common with ATLL cells, express both CD25 and FoxP3, and so contribute to the severe immune suppression typical of ATLL. We report here that the frequency of CD25+ cells varied independently of the frequency of FoxP3+ cells in both a cross‐sectional study and in a longitudinal study of 2 patients with chronic ATLL. Furthermore, the capacity of ATLL cells to suppress proliferation of heterologous CD4+CD25− cells correlated with the frequency of CD4+ FoxP3+ cells but was independent of CD25 expression. Finally, the frequency of CD4+FoxP3+ cells was inversely correlated with the lytic activity of HTLV‐1‐specific CTLs in patients with ATLL. We conclude that ATLL is not a tumor of FoxP3+ regulatory T cells, and that a population of FoxP3+ cells distinct from ATLL cells has regulatory functions and may impair the cell‐mediated immune response to HTLV‐1 in patients with ATLL. © 2009 UICC

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“…Adult T-cell leukemia/lymphoma (ATL) caused by human T-cell lymphotrophic virus type 1 (HTLV-1) is classified among the Retroviridae family, as is BLV (Uchiyama et al 1977). ATL was first reported in Japan in 1977.…”

Section: Discussionmentioning

confidence: 99%

Pathological findings of Japanese Black Cattle living in the restricted area of the Fukushima Daiichi Nuclear Power Plant accident, 2013–2016

Sasaki

Hiratani

Sato

et al. 2017

Animal Science Journal

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Fifty-one Japanese black cattle from four farms in the evacuation zone of the Fukushima nuclear accident were examined pathologically during the period, 2013-2016. We found no evidence of a radiation effect on pathological findings in any of these autopsy cases, although nine cases (3.7%) of enzootic bovine leukosis (EBL) and three cases (1.2%) of goiter were diagnosed. Estimated integrating dose of external exposure in EBL cases ranged from a maximum of 1200 mSv to a minimum of 72 mSv. Clinically, five cases showed wobble, dysstasia or paralysis. Exophthalmos was observed in three cases. Macroscopically, enlarged lymph nodes, multiple irregular masses of intra-abdominal and intrapelvic adipose tissue, diffuse thickening of the abomasal submucosa with ulceration, and numerous white nodules of myocardium were observed. Histologically, neoplastic lymphoid cells were extensively proliferated and infiltrated in the lesions. Lymphoid tumor cells showed mature or large lymphoblastic appearance. Immunohistochemically, tumor cells were positive for BLA-36, CD20 and CD5, and negative for CD3. Three cases showed diffuse enlargement of the thyroid gland with no mass or nodule lesion. Histologically, diffuse proliferation of follicular epithelium was observed with preservation of normal structures. There were no malignant findings such as cellular atypia or invasion to capsule.

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Adult T-cell leukemia: clinical and hematologic features of 16 cases

Cited by 1,700 publications

References 0 publications

Visualization of HTLV-1–Specific Cytotoxic T Lymphocytes in the Spinal Cords of Patients With HTLV-1–Associated Myelopathy/Tropical Spastic Paraparesis

Visualization of HTLV-1–Specific Cytotoxic T Lymphocytes in the Spinal Cords of Patients With HTLV-1–Associated Myelopathy/Tropical Spastic Paraparesis

FoxP3⁺ regulatory T cells are distinct from leukemia cells in HTLV‐1–associated adult T‐cell leukemia

Pathological findings of Japanese Black Cattle living in the restricted area of the Fukushima Daiichi Nuclear Power Plant accident, 2013–2016

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Adult T-cell leukemia: clinical and hematologic features of 16 cases

Cited by 1,700 publications

References 0 publications

Visualization of HTLV-1–Specific Cytotoxic T Lymphocytes in the Spinal Cords of Patients With HTLV-1–Associated Myelopathy/Tropical Spastic Paraparesis

Visualization of HTLV-1–Specific Cytotoxic T Lymphocytes in the Spinal Cords of Patients With HTLV-1–Associated Myelopathy/Tropical Spastic Paraparesis

FoxP3+ regulatory T cells are distinct from leukemia cells in HTLV‐1–associated adult T‐cell leukemia

Pathological findings of Japanese Black Cattle living in the restricted area of the Fukushima Daiichi Nuclear Power Plant accident, 2013–2016

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FoxP3⁺ regulatory T cells are distinct from leukemia cells in HTLV‐1–associated adult T‐cell leukemia