Adult T Cell Leukemia Histological Classification and Characteristics

Hanaoka, Masao; Sasaki, Masanori; Matsumoto, Hidetoshi; Tankawa, Hidemitsu; Yamabe, Hirohiko; Tomimoto, Kazuhiko; Tasaka, Chikao; Fujiwara, Hisayoshi; Uchiyama, Takashi; Takatsuki, Kiyoshi

doi:10.1111/j.1440-1827.1979.tb00940.x

Cited by 45 publications

(35 citation statements)

References 10 publications

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“…[8][9][10] The chronic-stage ATLL is characterized by leukocytosis, whereas the acute stage is characterized by multicentric lymphomatous masses, lymphoadenopathy, and hepatosplenomegaly. [11][12][13] Diagnostic criteria of ATLL include demonstration of clonally integrated HTLV-1 in neoplastic lymphocytes. 14,15 Identification of primary target cells that harbor HTLV-1 infection in infants and characterization of factors that promote virally induced transformation are difficult to identify primarily because of the extremely long clinical latent period to ATLL development and the lack of appropriate animal models that accurately recapitulate leukemogenesis.…”

Section: Introductionmentioning

confidence: 99%

Adult T-cell leukemia/lymphoma development in HTLV-1–infected humanized SCID mice

Banerjee

Tripp²,

Lairmore

et al. 2010

Blood

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Section: Introductionmentioning

confidence: 99%

Adult T-cell leukemia/lymphoma development in HTLV-1–infected humanized SCID mice

Banerjee

Tripp²,

Lairmore

et al. 2010

Blood

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“…observed in 26 ATL patients who have undergone autopsy (18). Likewise, the frequent occurrence of opportunistic infections in ATL patients and in HTLV-1 carriers was found to correlate with a low number of naive T lymphocytes (45).…”

Section: Discussionmentioning

confidence: 95%

“…Before reverse transcription, RNAs were first treated with 10 U of RNase-free DNase I (QIAGEN) for 30 min at 27°C and then for 10 min at 60°C. This RNA sample was then reverse transcribed at 42°C for 1 h in a total volume of 20 l reaction buffer (50 mM Tris, pH 8.3, 30 mM KCl, 3 mM MgCl 2 , 10 mM dithiothreitol) containing 100 U of SuperScriptII RNase H Ϫ reverse transcriptase (RT; Invitrogen), 100 pmol of oligo(dT) [12][13][14][15][16][17][18] (Invitrogen), and 20 U of RNase inhibitor (Rnasin; Promega). A reaction without RT was performed in parallel to serve as control for the absence of DNA contamination.…”

Section: Cells and Plasmidsmentioning

confidence: 99%

Human T-Cell Leukemia Virus Type 1 Tax Protein Down-Regulates Pre-T-Cell Receptor Alpha Gene Transcription in Human Immature Thymocytes

Wencker

Sausse

Derse

et al. 2007

J Virol

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The human pre-T-cell receptor alpha (TCR␣; pT␣) gene encodes a polypeptide which associates with the TCR␤ chain and CD3 molecules to form the pre-TCR complex. The surface expression of the pre-TCR is pT␣ dependent, and signaling through this complex triggers an early ␣␤ T-cell developmental checkpoint inside the thymus, known as ␤-selection. E2A transcription factors, which are involved at multiple stages of T-cell development, regulate the transcription of the pT␣ gene. Here we show that the regulatory protein Tax of the human T-cell leukemia virus type 1 (HTLV-1) efficiently suppresses the E47-mediated activation of the pT␣ promoter. Furthermore, we report that in Tax lentivirally transduced human MOLT-4 T cells, which constitutively express the pT␣ gene, the amount of pT␣ transcripts decreases. Such a decrease is not observed in MOLT-4 cells transduced by a vector encoding the Tax mutant K88A, which is unable to interact with p300. These data underline that Tax inhibits pT␣ transcription by recruiting this coactivator. Finally, we show that the expression of Tax in human immature thymocytes results in a decrease of pT␣ gene transcription but does not modify the level of E47 transcripts. These observations indicate that Tax, by silencing E proteins, down-regulates pT␣ gene transcription during early thymocyte development. They further provide evidence that Tax can interfere with an important checkpoint during T-cell differentiation in the thymus.

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“…Japanese authors had previously proposed a system using quite similar terminology to subclassify cases of adult T-cell leukemia (10). Morphometry, together with virology and functional studies, could provide objective evidence to aid the study of the relations between Japanese and Western PTCL (17), which are as yet unclear.…”

Section: Discussionmentioning

confidence: 99%

Can peripheral T‐Cell lymphomas be morphologically subclassified? A morphometric approach to 21 cases

et al. 1986

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Nantes (J.L.H.), FranceMorphometric analysis of nuclear sizes and shapes was carried out on semithin sections of lymph node for 21 patients suffering from non-Hodgkin's peripheral T-cell malignant lymphoma (ML) (excluding mycosis and Sezary syndrome). Twenty cases of B-cell ML and three cases of Sezary syndrome with massive lymph node infiltration were also studied as references, Wright and Xsaacson's recent proposals were applied to classify the peripheral T-cell MLs into monomorphic mediumcell ML (eight cases), pleomorphic ML (nine cases), and monomorphic large-cell ML (four cases). These three classes were readily distinguishable by morphometric analysis of nuclear sizes. Nuclear areas and their coeffNode-based malignant peripheral T-cell lymphomas (PTCL) are rare in Western countries. The detailed histological picture of such lymphomas is known only through publications of isolated cases or short series (1,15,17,18,23,25,33-36). The difficulty of classifying these tumors histologically was emphasized in a recent report of ours based on 16 cases of PTCL (3). In order to analyze objectively the possibility of subclassifying such lymphomas, we applied morphometric analysis of nuclear size and shapes (2830) to a series of 21 cases of PTCL, comprising nine new cases and 12 that had been previously studied (3). These cases were classified according to Wright and Isaacson's recent proposals for classifying PTCL (38) and according to the Working Formulation for Clinical Usage (22). The aim of this study was to 1) analyze the relations between morphological class, mitotic activity, and other histological parameters such as vascular hyperplasia and the quantity of eosinophils, plasmocytes, and histiocytes, 2) search for correlations between class and immunological phenotype, and 3) with the help of morphometry, arrive a t a more decients of variation were higher in pleomorphic MLs than in monomorphic mediumcell MIAs (p < 0.01). Large-cell monomorphic MLs were set apart by the histograms of their nuclear sizes. The mitoses were evaluated on histological sections and found to be more numerous in pleomorphic ML than in monomorphic medium-cell ML (p < 0.05). Nuclear irregularity in the 21 cases of peripheral Tcell ML was lower than in Sezary cells. Morphometry clearly demonstrates the morphological distinctiveness of the subclasses of peripheral T-cell ML. Their biological significance has yet to be determined. Key terms: Morphometry.~ tailed description of the subgroups of PTCL.MATERIAL AND METHODS Patients In 21 patients aged 27 to 79 years, the diagnosis of malignant lymphoma (ML) was based on a biopsy of superficial lymph nodes. All but patients 4 and 16 were of European origin. The T nature of the lymphomas was established using conventional immunological markers. Malignant cells from 15 of the patients had been studied using a panel of monoclonal antibodies including OKT4 and OKT8. All methods were previously described (3,20,21). Cases 1,7,8,[17][18][19][20] were T4+T8-, cases 3 , 5 , and 12 were T4-T8+, cases 10,13...

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Adult T Cell Leukemia Histological Classification and Characteristics

Cited by 45 publications

References 10 publications

Adult T-cell leukemia/lymphoma development in HTLV-1–infected humanized SCID mice

Adult T-cell leukemia/lymphoma development in HTLV-1–infected humanized SCID mice

Human T-Cell Leukemia Virus Type 1 Tax Protein Down-Regulates Pre-T-Cell Receptor Alpha Gene Transcription in Human Immature Thymocytes

Can peripheral T‐Cell lymphomas be morphologically subclassified? A morphometric approach to 21 cases

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