Adult T Cell Leukemia in Hemodialysis Patients from the Kagoshima District, an Area in Which Human T Cell Leukemia Virus Type I Is Highly Endemic

Uematsu, Takashi; Hanada, Shuichi; Saito, Takeshi; Otsuka, Maki; Komidori, Kazuo; Osaki, Kazuya; Uemura, Shinichiro; Ueda, Hiroaki; Harada, Ryuji; Hashimoto, Shuji

doi:10.1159/000185295

Cited by 4 publications

(9 citation statements)

References 18 publications

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“…In Japan, increased adult T-cell leukemias are also described in MHD patients due to an activation of oncogenic human T-cell leukemia virus type I [54].…”

Section: Chronic Infections and Inflammationsmentioning

confidence: 99%

Cancer in End-Stage Renal Disease: Potential Factors Involved

Vamvakas

Bahner²,

Heidland³

1998

Am J Nephrol

166

113

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Increased incidence of cancer at various sites is observed in patients with end-stage renal disease (ESRD). In particular, lymphomas and carcinomas of the kidney, prostate, liver and uterus show an enhanced prevalence in these subjects compared with the general population. A multitude of factors directly or indirectly associated with the renal disease and the treatment regimens may contribute to the increased tumor formation in these patients. Impaired function of the immune system and of DNA repair mechanisms as well as reduced antioxidant defense, accumulation of carcinogenic compounds partly due to reduced renal elimination as well as chronic infections and inflammations are found more frequently in patients with ESRD compared with the general population and may act in concert to accelerate malignant transformation and tumor formation.

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“…In Japan, increased adult T-cell leukemias are also described in MHD patients due to an activation of oncogenic human T-cell leukemia virus type I [54].…”

Section: Chronic Infections and Inflammationsmentioning

confidence: 99%

Cancer in End-Stage Renal Disease: Potential Factors Involved

Vamvakas

Bahner²,

Heidland³

1998

Am J Nephrol

166

113

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“…Several studies, especially from Japan and Iran, have found high rates of HTLV‐1 infection ranging from 6.7% to 21.2% among people with CKD . To date, no study has reported renal disease among people with HTLV‐1 in the Caribbean and south America, two other major HTLV‐1 endemic areas.…”

Section: Discussionmentioning

confidence: 94%

“…Limited evidence suggests that HTLV‐1a infection might be associated with CKD. When compared with controls without CKD, higher HTLV‐1 seropositivity rates were observed among haemodialysis (HD) patients, and those with histologically confirmed primary glomerulonephritis . However, only one study measured HTLV‐1a PVL, which were higher among CKD cases .…”

Section: Introductionmentioning

confidence: 99%

Higher human T‐cell leukaemia virus type 1 (HTLV‐1) proviral load is associated with end‐stage kidney disease in Indigenous Australians: Results of a case‐control study in central Australia

Talukder

Walley

Pham

et al. 2019

Journal of Medical Virology

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Case series suggest that human T‐cell leukaemia virus type 1 (HTLV‐1) is associated with kidney disease; however, little is known about the impact of proviral load (PVL). The present study was commenced to determine whether higher HTLV‐1 PVL is associated with end stage kidney disease (ESKD) in Indigenous Australians. A case‐control study was conducted in Alice Springs Hospital (ASH), 1 July 2007 to 30 November 2015. Cases included all 80 Indigenous adults (>17 years) with HTLV‐1c and ESKD, matched 1:1 by sex to controls with HTLV‐1 who had no renal disease or other recognised disease associations of HTLV‐1, and were recruited during the same period. The association between PVL and ESKD was assessed using logistic regression. Median (IQR) HTLV‐1c PVL for subjects with ESKD (6.86, IQR (3.35, 8.23) log copies per 105 peripheral blood leukocytes (PBL) (ie, 0.95; IQR, 0.03; 3.70% PBL) was significantly higher than that of the asymptomatic group (3.47; IQR (−0.04, 6.61) log copies per 10 5 PBL (ie, 0.01; IQR, 0.00; 0.52% PBL) (asymptomatic vs ESKD, P (ranksum) < .001). Major factors associated with ESKD were diabetes (adjusted odds ratio [aOR], 21.80; 95% CI, 4.84, 98.22; P < .001), hypertension (aOR, 4.16; 1.11, 15.64; P = .03), remote residence (aOR, 5.34; 95% CI, 1.17, 27.29; P = .03) and HTLV‐1c PVL greater than or equal to 100 copies per 10 5 PBL (aOR, 3.67; 95% CI, 1.36, 9.92; P = .01). Higher HTLV‐1c PVL are strongly associated with inflammatory diseases. The high HTLV‐1c PVL reported here may have clinical implications for people with HTLV‐1 who require haemodialysis. Longitudinal studies are required to determine whether this association is causal.

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“…The routine administration of blood products to CKD5 patients at a time when blood donations were not screened for HTLV-1 complicates the interpretation of earlier studies. [26][27][28] However, blood donors have been tested for HTLV-1 in Japan, Australia, and Iran since 1986, 29 1993, 32 and 1995, 33 respectively, making HTLV-1 transmission by blood transfusion unlikely in recent studies. We previously found a significantly higher HTLV-1 PVL among cases with CKD5 relative to controls without CKD 30 which suggests a potential mechanism for renal injury.…”

Section: Discussionmentioning

confidence: 99%

“…Limited epidemiological evidence supports an association between HTLV‐1 infection and CKD. In HTLV‐1 endemic areas in Iran and Japan, HTLV‐1 seropositivity rates are higher among patients receiving renal replacement therapy than those without CKD 23–28 . Interpreting earlier studies 26–28 is rendered difficult by the routine administration of blood transfusions to patients with CKD stage 5 (CKD5) before the introduction of HTLV‐1 testing of blood donors 29 .…”

Section: Introductionmentioning

confidence: 99%