Adult T‐cell lymphoma involving the leptomeninges associated with a spinal cord schwannoma

Abstract

Adult T-cell lymphoma (ATL-L) developing initially in the meninges is rare. An autopsy case of ATL-L with an acute onset of meningitis and generalized lymphadenopathy in association with a cervical cord schwannoma is reported here. A 78-year-old woman with sensori-motor weakness of both arms over a 1-year period, developed febrile episodes and drowsiness with neck stiffness. Lumbar puncture revealed an increased protein content (161 mg/dL) and increased cell count (463/3) consisting of 99% of lymphocytes which contained atypical lymphocytes with multilobulated nuclei ('flower cells'), which are characteristic of ATL-L. Viral titers were positive only for HTLV-I antibodies (serum X 640: CSF X 16). Biopsy of an enlarged retroperitoneal lymph node revealed malignant lymphoma of the T-cell type. Brain MRI was negative, whereas an intradural extramedullary mass was found at the C4 level. With a diagnosis of ATL-L stage IV, chemotherapy was commenced, which was effective in reducing the generalized lymphadenopathy as well as the cervical mass and restoring the CSF findings to normality. The cervical cord mass was verified to be a solitary schwannoma, and ATL-L involvement was found not only in the leptomeninges, but also within the cervical cord schwannoma.

Performance Evaluation of the Integration Between a Thermo–Photo–Voltaic Generator and an Organic Rankine Cycle

“…It results imperatively to send these photons back to the radiator in order to conserve heat and reduce the fuel consumption to achieve the required emitter temperatures. Many types of filters have been developed, such as plasma filters, dielectric stacks, or back-surface reflectors [16][17][18][19]; also, filters based on muhiple layers of SÍO2 have been realized. In conclusion, with reference to Fig.…”

Investigation of Stress Intensity Factors for an Interface Crack in Multi-Interface Materials Using an Interaction Integral Method

“…This method was used to evaluate the mixed-mode SIFs of three-dimensional (3D) interface crack [9][10][11]. The interaction integral method was employed in conjunction with the boundary element method (BEM) and the XFEM to analyze two-dimensional (2D) and 3D interface crack problems efficiently [12][13][14][15]. Moreover, the interaction integral method has been developed to calculate the SIFs of 3D curvilinear interface cracks under nonuniform temperature load [16] and to solve the interface crack problems in layered orthotropic solids [17].…”