Adult-to-Adult Transplantation of the Right Hepatic Lobe from a Living Donor

Trotter, James F.; Wachs, Michael; Everson, Gregory T.; Kam, Igal

doi:10.1056/nejmra011629

Cited by 421 publications

(292 citation statements)

References 39 publications

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“…Recently, live donor liver transplantation has emerged as a solution to shortage of liver grafts and is theoretically a more preferred choice for HCC patients because the waiting time is significantly reduced. However, the potential risk of donor hepatectomy (0.3-0.5% mortality) and relatively higher recipient complication (20-40%) need to be considered in offering such treatment [275]. Furthermore, live donor liver grafts are often small for size and the subsequent acute-phase injury, regeneration, and angiogenesis might increase the chance of tumor recurrence [276].…”

Section: Liver Transplantationmentioning

confidence: 99%

Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma

et al. 2010

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Introduction The Asian Pacific Association for the Study of the Liver (APASL) convened an international working party on the management of hepatocellular carcinoma (HCC) in December 2008 to develop consensus recommendations. Methods The working party consisted of expert hepatologist, hepatobiliary surgeon, radiologist, and oncologist from Asian-Pacific region, who were requested to make drafts prior to the consensus meeting held at Bali, Indonesia on 4 December 2008. The quality of existing evidence and strength of recommendations were ranked from 1 (highest) to 5 (lowest) and from A (strongest) to D (weakest), respectively, according to the Oxford system of evidence-based approach for developing the consensus statements. 123Hepatol Int (2010) 4: 439-474 DOI 10.1007/s12072-010-9165-7 Results Participants of the consensus meeting assessed the quality of cited studies and assigned grades to the recommendation statements. Finalized recommendations were presented at the fourth APASL single topic conference on viral-related HCC at Bali, Indonesia and approved by the participants of the conference.

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Section: Liver Transplantationmentioning

confidence: 99%

Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma

et al. 2010

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“…Kidney transplants from living related and unrelated donors have been shown to be highly successful (19). Living related liver transplant activity is also increasing world wide with good results (20). However, lung or pancreas living transplantation remains anecdotal (4).…”

Section: Opportunities For Improvementmentioning

confidence: 99%

Optimizing Cadaveric Organ Procurement: the Catalan and Spanish Experience

Miranda

Vilardell²,

Grinyó

2003

American Journal of Transplantation

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The need to face the increasing gap between the supply and the demand of transplants has led to the development of a permanent network of trained medical staff responsible for the organ donation and removal process in all centers accredited for that process. In Spain, this activity received a specific budget, like any other medical activity in hospitals, and the responsible staff became accountable for performance. This system dramatically increased the number of potential donors referred, not only young donors with trauma, but also elderly donors dying from stroke. The effect was that the donation rate increased by more than 100% in 10 years (from 14 to 34 donors per million population). Consequently, so did all the transplant figures. In some areas, such as Catalonia, it has been demonstrated that sustained kidney transplant activity of over 60 procedures per million population can maintain or slightly decrease the waiting list, despite increasing incidence and prevalence of end-stage renal failure. Quality monitoring of the donation and retrieval process shows that there are still opportunities for improvement if all potential donors are referred and all technical problems are overcome. Living donation and nonheart beating organ retrieval should also be promoted.

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“…in patients undergoing living-donor-liver-transplantation of the right lobe [14,56]. A differentiated selection of donor and recipient simply based on epidemiological data might help to avoid the accumulation of predisposing factors.…”

Section: Ischemic Type Biliary Lesions 235mentioning

confidence: 99%