Adult Wilms tumor with inferior vena cava thrombus and distal deep vein thrombosis – a case report and literature review

Ratajczyk, Krzysztof; Czekaj, Adrian; Rogala, Joanna; Kowal, Paweł

doi:10.1186/s12957-018-1343-4

Cited by 13 publications

(9 citation statements)

References 32 publications

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“…Around 300 adult Wilms' tumor cases have been reported in the literature [4]; due to the scarcity of cases, no clinical studies reporting a standard of management in the adult age are available, and in most isolated cases, the management is extrapolated from pediatric guidelines [6][7][8][9][10][11][12][13]. In the particular case of Colombia, only two adult Wilms' tumor cases have been reported, which were in an initial stage and underwent radical nephrectomy [7,8].…”

Section: Discussionmentioning

confidence: 99%

Adult Wilms' Tumor: Case Report and Literature Review

Yepes¹,

Bermúdez²,

Camacho-Nieto³

et al. 2021

Cureus

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Wilms' tumor is childhood's most common renal tumor, and its presentation in the adult age is extremely rare. Due to the low frequency in adults, no standard management guidelines are available for this population, also the natural history of the disease and management is unclear. We present a case report of a 31-year-old woman with metastatic Wilms' tumor, with lymph node, lung and liver involvement; systemic treatment with chemotherapy was started, with complete clinical response. Finally, a literature review is performed to showcase the differences in the clinical course, prognosis, and treatment alternatives, in adult disease compared to childhood.

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Section: Discussionmentioning

confidence: 99%

Adult Wilms' Tumor: Case Report and Literature Review

Yepes¹,

Bermúdez²,

Camacho-Nieto³

et al. 2021

Cureus

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“…In inferior vena cava, tumor thrombus is observed in 4-10% of patients, with 1-3% of right atrium involvement. 17 Therefore, preoperative cardiac examinations should be performed to prevent cardiovascular complication. This report can help pediatric surgeons become more familiar with cardiomyopathy caused by WT.…”

Section: Discussionmentioning

confidence: 99%

Hypertensive Cardiomyopathy with Congestive Heart Failure in an Infant with Unilateral Wilms Tumor: A Case Report

et al. 2021

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Wilms tumor (WT) is the most common malignant kidney tumor in children. High blood pressure is seen in up to 55% of children with WT. However, hypertensive cardiomyopathy with congestive heart failure due to WT is remarkably rare, with only several cases reported worldwide. In this report, a pediatric case of WT with hypertension causing hypertensive cardiomyopathy and congestive heart failure is presented. An 8-month-old male child with abdominal distension was seen by his primary physician. He was referred to our hospital for further examination and treatment. Abdominal contrast-enhanced computed tomography demonstrated a weakly enhancing, large abdominal mass, which was larger than 12 cm. Two-dimensional transthoracic echocardiography showed a diffuse hypokinetic left ventricle. The patient was diagnosed with cardiomyopathy caused by hypertension. Open surgical resection of the mass was successfully performed. His postoperative course was uncomplicated, and the patient was successfully discharged. The plasma renin activity was maintained at a high level even after left nephrectomy, suggesting that the right kidney was likely the source of renin secretion. Mechanical compression of the right renal blood vessels by a greatly enlarged left kidney can cause right renal ischemia, which activates renin excretion. Nephrectomy can be an effective treatment for a WT patient with hypertension causing hypertensive cardiomyopathy, and then cardiac function will be improved within several weeks. We recommend routine echocardiography surveillance in patients with WT. This report can help pediatric surgeons become more familiar with cardiomyopathy caused by WT.

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“…However, anticoagulation should be considered if a plain thrombus is found in addition to a tumor thrombus or if distal thrombosis develops without collateral venous pathway complicated with deep venous thrombosis (Quencer et al, 2017;Ratajczyk et al, 2018). Continuously monitoring vital signs will detect early signs of PE such as desaturation and tachycardia.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Embolism and Wilms’ Tumor. Can It Be Any Worse? Case Report

Zhran¹,

Baothman²

2021

AJHMN

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It is common for Wilms tumor to invade the inferior vena cava and right atrium, but a massive pulmonary embolism is rare. This case report describes an 8-year-old male patient who presented to an outpatient clinic with mild pain associated with subjective fever for 1 week. A left renal mass with extension of an inferior vena cava thrombus was seen on abdominal computed tomography, suggesting a Wilms tumor. An exploratory laparotomy biopsy was scheduled, but not completed because the patient’s health suddenly deteriorated, and he died despite high-quality cardiopulmonary resuscitation. A massive pulmonary embolism was found to cause a sudden and fatal cardiac arrest.

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Adult Wilms tumor with inferior vena cava thrombus and distal deep vein thrombosis – a case report and literature review

Cited by 13 publications

References 32 publications

Adult Wilms' Tumor: Case Report and Literature Review

Adult Wilms' Tumor: Case Report and Literature Review

Hypertensive Cardiomyopathy with Congestive Heart Failure in an Infant with Unilateral Wilms Tumor: A Case Report

Pulmonary Embolism and Wilms’ Tumor. Can It Be Any Worse? Case Report

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