Adulthood cognitive trajectories over 26 years and brain health at 70 years of age: findings from the 1946 British Birth Cohort

James, Sarah‐Naomi; Nicholas, Jennifer M.; Lu, Kirsty; Keshavan, Ashvini; Lane, Christopher A.; Parker, Thomas D.; Buchanan, Sarah M; Keuss, Sarah E; Murray‐Smith, Heidi; Wong, Andrew; Cash, David M.; Malone, Ian; Barnes, Josephine; Sudre, Carole H.; Coath, William; Modat, Marc; Ourselin, Sébastien; Crutch, Sebastian J.; Kuh, Diana; Fox, Nick C.; Schott, Jonathan M.; Richards, Marcus

doi:10.1016/j.neurobiolaging.2022.10.003

Cited by 2 publications

(2 citation statements)

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“…The hippocampus is of interest in hybrid imaging because this area is known to be important in memory and cognition, and volume losses have been associated with MCI and dementia. One study by James et al found that patients with smaller hippocampal volume at age 70 had a faster search speed decline in the preceding 26 years, which was measured by the response time to identifying a target within a visual set-up [ 35 , 99 ]. For every 1 mL decrease in volume, there was an additional decline of approximately 1 point in search speed per year.…”

Section: Discussionmentioning

confidence: 99%

“…Amyloid and tau accumulation is the most common assessment performed in the evaluation of AD. A significant number of clinical studies within this review show an increased amyloid and tau protein burden in patients with different types of dementia [ 25 , 31 , 35 , 37 , 38 , 55 , 94 ]. These subtypes can be further differentiated depending on the local distribution of the amyloid.…”

Section: Discussionmentioning

confidence: 99%

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Current Trends and Applications of PET/MRI Hybrid Imaging in Neurodegenerative Diseases and Normal Aging

Lee,

Renslo,

Wong

et al. 2024

Diagnostics

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Dementia is a significant global health issue that is exacerbated by an aging population. Imaging plays an established role in the evaluation of patients with neurocognitive disorders such as dementia. In current clinical practice, magnetic resonance imaging (MRI) and positron emission tomography (PET) are primary imaging modalities used separately but in concert to help diagnose and classify dementia. The clinical applications of PET/MRI hybrid imaging in dementia are an active area of research, particularly given the continued emergence of functional MRI (fMRI) and amyloid PET tracers. This narrative review provides a comprehensive overview of the rationale and current evidence for PET/MRI hybrid dementia imaging from 2018 to 2023. Hybrid imaging offers advantages in the accuracy of characterizing neurodegenerative disorders, and future research will need to address the cost of integrated PET/MRI systems compared to stand-alone scanners, the development of new biomarkers, and image correction techniques.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Current Trends and Applications of PET/MRI Hybrid Imaging in Neurodegenerative Diseases and Normal Aging

Lee,

Renslo,

Wong

et al. 2024

Diagnostics

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Does the positive association between social relationships and cognition continue until very old age?

Vogel,

Oliva y Hausmann,

Zank

2024

Eur J Ageing

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In current research, social relationships are increasingly recognized for their positive associations with cognitive outcomes in older adults. One of the most vulnerable groups for cognitive decline are very old adults (80+ years). However, they are relatively underrepresented in the field. Therefore, our study aimed to test if social relationships remain a protective factor against cognitive decline in very old age, using a representative sample from the Study of Quality of Life and Well-Being in North-Rhine Westphalia (NRW80+ Study). We hypothesized that social characteristics would be positively associated with global cognition and episodic memory cross-sectionally and would predict cognitive performance two years later. 1.207 very old adults were included in the representative, cross-sectional analyses, and 639 in the panel analyses. They were aged between 80 and 103 years and showed no signs of dementia. The associations between various social aspects and cognitive functions were investigated using hierarchical linear regression, controlling for relevant sociodemographic and health characteristics. Cross-sectionally, leisure engagement was positively associated with episodic memory (β = 0.53 [0.26, 0.79], p < .01) and global cognition (β = 0.50 [0.22, 0.79], p < .01), while overall network size was positively associated with global cognition (β = 0.04 [0.02, 0.07], p < .01). In contrast, we observed no associations between baseline social relationships and cognitive functions two years later. The findings suggest that while social relationships are associated with cognitive functions in very old age, short-term protective effects such as over two years may be less robust compared to other age groups.

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Adulthood cognitive trajectories over 26 years and brain health at 70 years of age: findings from the 1946 British Birth Cohort

Cited by 2 publications

References 58 publications

Current Trends and Applications of PET/MRI Hybrid Imaging in Neurodegenerative Diseases and Normal Aging

Current Trends and Applications of PET/MRI Hybrid Imaging in Neurodegenerative Diseases and Normal Aging

Does the positive association between social relationships and cognition continue until very old age?

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