Adulthood-Onset Celiac Disease Is Associated with Intercellular Adhesion Molecule-1 (ICAM-1) Gene Polymorphism

ICAM1 R241 is not associated with celiac disease in the Spanish population

“…No association between CD ABBREVIATIONS CD celiac disease CI confidence interval ICAM-1 intercellular adhesion molecule-1 OR odds ratio SNPs single nucleotide polymorphisms TDT transmission disequilibrium test and any of the SNPs studied existed. We could not replicate the previously described association between R241 and CD in the French population [11], despite our study being wellenough powered. The statistical power of our study was above 99% when an odds ratio (OR) value of 2.9, as described by Abel et al [11], is considered [and even as high as 98% when considering OR ϭ 1.7, which is the lower limit of the 95% confidence interval (CI)].…”

“…In the French population, an increased frequency of R241 was observed in CD patients [11], although this association was not reported in an Indian population [12]. Those polymorphisms were also studied in several autoimmune diseases such as multiple sclerosis [13,14], type 1 diabetes [15,16], inflammatory bowel disease [17,18], and Graves' disease [19], with variable results.…”

Lack of association between intercellular adhesion molecule-1 (ICAM-1) polymorphisms and polycystic ovary syndrome

“…SNP genotypes were tested for departures from HWE for controls and patients, and both polymorphisms were in HWE. The allelic frequencies of G (0.96) and R (0.04) for ICAM-1 241 and K (0.56) and E [22], English [23] and German [24] populations. We did not find any evidence for association between PCOS and the two individual SNPs (Table 2).…”

Searching for genes influencing a complex disease: the case of coeliac disease

“…95 The ICAM-1 gene was found to associate to CD when analysing 180 unrelated French CD cases and 212 controls. 96 When the authors stratified for age of disease onset, the same variant conferred even stronger predisposition to the adult-onset disease. 96 Also from 19p13, cytochrome P450 F3 and F2 genes (CYP4F3 and CYP4F2) showed an effect on familial clustering in a Dutch CD cohort.…”

“…96 When the authors stratified for age of disease onset, the same variant conferred even stronger predisposition to the adult-onset disease. 96 Also from 19p13, cytochrome P450 F3 and F2 genes (CYP4F3 and CYP4F2) showed an effect on familial clustering in a Dutch CD cohort. CYP4F3 and CYP4F2 catalyse the inactivation of leukotriene B4 (LTB4), a potent mediator of inflammation responsible for recruitment and activation of neutrophils.…”