Adults with Down Syndrome: Characterization of a Portuguese Sample

Breia, Paula; Mendes, Renato; Silvestre, Ana; Goncąlves, Maria Joaõ; Figueira, Maria João; Bispo, Regina

doi:10.20344/amp.4898

Cited by 10 publications

(18 citation statements)

References 33 publications

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“…below the normal range threshold). Mean IQ scores for persons with TRS21, between 40 and 50 (Breia et al 2014 ;Carlier et al 2011 ;Carr 2012 ) is only an estimate, as scores are influenced by demographic characteristics of the study sample (e.g. age or the institutional environment) and the lowest score of the IQ test used (40 or 45 on the Wechsler scales, but lower for other tests).…”

Section: Introductionmentioning

confidence: 99%

Differential Brain, Cognitive and Motor Profiles Associated with Partial Trisomy. Modeling Down Syndrome in Mice

et al. 2017

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Section: Introductionmentioning

confidence: 99%

Differential Brain, Cognitive and Motor Profiles Associated with Partial Trisomy. Modeling Down Syndrome in Mice

et al. 2017

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“…; Breia et al . ; Jensen & Bulova ). The possible explanations for lower cancer risk in DS includes reduced environmental exposure, extra tumour‐suppressor genes on chromosome 21 and slower rate of cell division and higher apoptotic rate in trisomic cells (Yang et al .…”

Section: Discussionmentioning

confidence: 97%

Hospitalisation of adults with Down syndrome: lesson from a 10‐year experience from a community hospital

Chenbhanich

Phupitakphol

et al. 2018

J intellect Disabil Res

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Background Life expectancy of individuals with Down syndrome (DS) has improved significantly over the past decades. However, there are sparse data documenting the co‐morbidities and hospitalisation of adult patients with DS in the literature. The aim of this study was to characterise the co‐morbidities and pattern of hospitalisation in adult patients with DS during a 10‐year period at the community hospital as well as to compare hospitalisation parameters with the general adult population during the same years. Method We reviewed the medical records of 81 hospitalisations from 37 patients with DS aged 21 to 68 years at Metrowest Medical Center during a 10‐year period and compared with those of the general adult population during the same time. Co‐morbidities were also described. Results Adults with DS had a mean age at admission of 48.6 ± 8.8 years with the median length of stay of 3 days (interquartile range 4 days). Male patients were hospitalised longer than female patients (mean 5.0 vs. 2.8 days; P < 0.05), and patients who lived at home were admitted at earlier ages than those who came from residential healthcare facility (mean 41.5 vs. 52.2 years; P < 0.001). The most common cause of hospitalisation was pneumonia/aspiration syndrome (29.6%), and the most common co‐morbidity was gastroesophageal reflux disease (GERD)/dysphagia (70.3%). Presence of GERD/dysphagia or seizure disorder was significantly associated with multiple admission and readmission within 1 month (P < 0.05). The mortality rate was 4.9%, and the rate of intensive care unit admission was 8.6%. Conclusions Our cohort did not show statistically significant different hospitalisation parameters such as inpatient mortality and average length of stay when compared with general adult population hospitalised at the same years. The care of adult patients with DS presents challenges in internal medicine due to its unique co‐morbid profile and signifies the importance of multidisciplinary approach. In order to improve the care of this patient population, their co‐morbidities, particularly GERD/dysphagia and seizure disorder, should be optimally managed and comprehensively addressed when patients are hospitalised.

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“…These findings suggest that the pulmonary complications present in this population are not only the result of presence of laryngotracheal aspiration, and that issues such as GER and cardiac conditions deserve emphasis in the investigation of pulmonary complications (13) . Aspiration of reflux content is common in the pediatric population diagnosed with GER (14) , generating complaints about gagging during feeding, which may be mistaken for oropharyngeal symptoms. However, it is relevant to conduct an objective investigation on swallowing in this population, considering that other studies with larger samples have already demonstrated higher frequency of laryngotracheal aspiration (2,3) .…”

Section: Pharyngeal Transit Timementioning

confidence: 99%

“…Considering that significant difference between the youngest individual of the sample and the others was only observed in the TOTT, it is necessary to investigate deglutition performance regarding maturation of the CNS in this population because of the marked difference between this age group and the others. Therefore, we suggest that the influence of age on the biomechanics of swallowing be addressed in further studies on DS, because it is known that the processes of cerebral maturation and orofacial development cause changes in the oral structures, coordination of swallowing mechanisms, and oral modulation which can directly impact this function in the general population, including the DS population (14) .…”

Section: Pharyngeal Transit Timementioning

confidence: 99%

Análise qualitativa e quantitativa da deglutição orofaríngea na Síndrome de Down

Sales

Giacheti

Cola

et al. 2017

CoDAS

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RESUMO Objetivo Este estudo tem por objetivo descrever a análise qualitativa e quantitativa temporal da deglutição orofaríngea em crianças com diagnóstico de Síndrome de Down (SD). Método Estudo de série de seis casos, com idade variando de quatro a 17 meses (Média de 11,16 meses e mediana de 12 meses). Realizada análise qualitativa e quantitativa temporal da deglutição orofaríngea por meio de videofluoroscopia de deglutição e software específico. Foram analisados os parâmetros qualitativos de coordenação oral, resíduos orais, escape oral posterior, penetração, aspiração laringotraqueal e realizada análise do tempo de trânsito oral total (TTOT) e faríngeo. Resultados Verificou-se alteração em pelo menos quatro dos parâmetros qualitativos investigados. Somente um dos indivíduos apresentou diferença no TTOT quando comparado com os demais e não houve diferença no tempo de trânsito faríngeo entre os casos. Conclusão Houve alterações qualitativas na deglutição em crianças com SD e diferença no TTOT somente no caso de menor faixa etária.

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Adults with Down Syndrome: Characterization of a Portuguese Sample

Cited by 10 publications

References 33 publications

Differential Brain, Cognitive and Motor Profiles Associated with Partial Trisomy. Modeling Down Syndrome in Mice

Differential Brain, Cognitive and Motor Profiles Associated with Partial Trisomy. Modeling Down Syndrome in Mice

Hospitalisation of adults with Down syndrome: lesson from a 10‐year experience from a community hospital

Análise qualitativa e quantitativa da deglutição orofaríngea na Síndrome de Down

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